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Chemistry

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Also known as: 70059-30-2, Cimetidine hcl, Cimetidinehydrochloride, Cimetidine (hydrochloride), Cimetex, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine monohydrochloride
Molecular Formula
C10H17ClN6S
Molecular Weight
288.80  g/mol
InChI Key
QJHCNBWLPSXHBL-UHFFFAOYSA-N
FDA UNII
WF10491673

Cimetidine Hydrochloride
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
1 2D Structure

Cimetidine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine;hydrochloride
2.1.2 InChI
InChI=1S/C10H16N6S.ClH/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11;/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);1H
2.1.3 InChI Key
QJHCNBWLPSXHBL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(N=CN1)CSCCNC(=NC)NC#N.Cl
2.2 Other Identifiers
2.2.1 UNII
WF10491673
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Altramet

2. Biomet

3. Biomet400

4. Cimetidine

5. Cimetidine Hcl

6. Eureceptor

7. Hcl, Cimetidine

8. Histodil

9. Hydrochloride, Cimetidine

10. N-cyano-n'-methyl-n''-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanidine

11. Sk And F 92334

12. Sk And F-92334

13. Sk And F92334

14. Skf 92334

15. Skf-92334

16. Skf92334

17. Tagamet

2.3.2 Depositor-Supplied Synonyms

1. 70059-30-2

2. Cimetidine Hcl

3. Cimetidinehydrochloride

4. Cimetidine (hydrochloride)

5. Cimetex

6. 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine Monohydrochloride

7. N-cyano-n'-methyl-n''-[2-[[(5-methyl-1h-imidazol-4-yl)methyl]thio]ethyl]guanidine Hydrochloride

8. Endo

9. Tagamet Liquid

10. Wf10491673

11. Tagamet Injection

12. Guanidine, N''-cyano-n-methyl-n'-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)-, Monohydrochloride

13. Chebi:50362

14. N-cyano-n'-methyl-n''-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanidine Hydrochloride

15. Cimetidine Hydrochloride [usan]

16. Einecs 274-297-2

17. Unii-wf10491673

18. Einecs 276-264-8

19. Cimetidine Hydrochloride [usan:usp]

20. 71989-90-7

21. Schembl42142

22. Schembl42144

23. Cimetidine Hydrochloride (tn)

24. Cimetidine Hydrochloride (usp)

25. Chembl1201051

26. Schembl11156749

27. Dtxsid10990302

28. Cimetidine Hydrochloride [mi]

29. Cimetidine Hydrochloride In Sodium Chloride 0.9% In Plastic Container

30. Hy-14289a

31. Mfcd01724314

32. Tagamet Hydrochloride In Sodium Chloride 0.9% In Plastic Container

33. Akos015961108

34. Akos037643350

35. Ac-4278

36. Cimetidine Hydrochloride [mart.]

37. Cimetidine Hydrochloride [vandf]

38. Cimetidine Hydrochloride [usp-rs]

39. Cimetidine Hydrochloride [who-dd]

40. 1-cyano-2-methyl-3-[2-[(5-methyl-1h-imidazol-4-yl)methylsulfanyl]ethyl]guanidine;hydrochloride

41. As-15040

42. Guanidine, N'-cyano-n-methyl-n'-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)-, Monohydrochloride

43. N-cyano-n'-methyl-n''-(2-(((5-methyl-1h-imidazol-4-yl)methyl)thio)ethyl)guanidine Monohydrochloride

44. Db-055373

45. Cs-0031039

46. Ft-0602954

47. Cimetidine Hydrochloride [orange Book]

48. Cimetidine Hydrochloride [ep Monograph]

49. Cimetidine Hydrochloride [usp Monograph]

50. D03503

51. 059c302

52. A923492

53. W-104570

54. Q27122038

55. Cimetidine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

56. Cimetidine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

57. Cimetidine Hydrochloride, European Pharmacopoeia (ep) Reference Standard, European Pharmacopoeia (ep) Reference Standard

58. Guanidine, N-cyano-n'-methyl-n''-[2-[[(5-methyl-1h-imidazol-4-yl)methyl]thio]ethyl]-, Monohydrochloride

59. N-cyano-n''-methyl-n'-(2-{[(4-methyl-1h-imidazol-5-yl)methyl]sulfanyl}ethyl)guanidine--hydrogen Chloride (1/1)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 288.80 g/mol
Molecular Formula C10H17ClN6S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass288.0923934 g/mol
Monoisotopic Mass288.0923934 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count18
Formal Charge0
Complexity296
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCimetidine hydrochloride
Drug LabelCimetidine is a histamine H2 receptor-antagonist. Chemically it is N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-guanidine.The molecular formula for cimetidine hydrochloride is C10H16N6S HCl and the molecular weight i
Active IngredientCimetidine hydrochloride
Dosage FormInjectable; Solution
RouteInjection; Oral
Strengtheq 300mg base/2ml; eq 300mg base/5ml
Market StatusPrescription
CompanyWockhardt; Hi Tech Pharma; Ani Pharms; Pharm Assoc; Dava Pharms

2 of 2  
Drug NameCimetidine hydrochloride
Drug LabelCimetidine is a histamine H2 receptor-antagonist. Chemically it is N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]-ethyl]-guanidine.The molecular formula for cimetidine hydrochloride is C10H16N6S HCl and the molecular weight i
Active IngredientCimetidine hydrochloride
Dosage FormInjectable; Solution
RouteInjection; Oral
Strengtheq 300mg base/2ml; eq 300mg base/5ml
Market StatusPrescription
CompanyWockhardt; Hi Tech Pharma; Ani Pharms; Pharm Assoc; Dava Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Cytochrome P-450 CYP1A2 Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)


Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


Histamine H2 Antagonists

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Histamine-2 Receptor Antagonist [EPC]; Histamine H2 Receptor Antagonists [MoA]

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ABOUT THIS PAGE

Looking for 70059-30-2 / Cimetidine Hydrochloride API manufacturers, exporters & distributors?

Cimetidine Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cimetidine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cimetidine Hydrochloride manufacturer or Cimetidine Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cimetidine Hydrochloride manufacturer or Cimetidine Hydrochloride supplier.

PharmaCompass also assists you with knowing the Cimetidine Hydrochloride API Price utilized in the formulation of products. Cimetidine Hydrochloride API Price is not always fixed or binding as the Cimetidine Hydrochloride Price is obtained through a variety of data sources. The Cimetidine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cimetidine Hydrochloride

Synonyms

70059-30-2, Cimetidine hcl, Cimetidinehydrochloride, Cimetidine (hydrochloride), Cimetex, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine monohydrochloride

Cas Number

70059-30-2

Unique Ingredient Identifier (UNII)

WF10491673

About Cimetidine Hydrochloride

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

Histodil Manufacturers

A Histodil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Histodil, including repackagers and relabelers. The FDA regulates Histodil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Histodil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Histodil manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Histodil Suppliers

A Histodil supplier is an individual or a company that provides Histodil active pharmaceutical ingredient (API) or Histodil finished formulations upon request. The Histodil suppliers may include Histodil API manufacturers, exporters, distributors and traders.

click here to find a list of Histodil suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Histodil USDMF

A Histodil DMF (Drug Master File) is a document detailing the whole manufacturing process of Histodil active pharmaceutical ingredient (API) in detail. Different forms of Histodil DMFs exist exist since differing nations have different regulations, such as Histodil USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Histodil DMF submitted to regulatory agencies in the US is known as a USDMF. Histodil USDMF includes data on Histodil's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Histodil USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Histodil suppliers with USDMF on PharmaCompass.

Histodil GMP

Histodil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Histodil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Histodil GMP manufacturer or Histodil GMP API supplier for your needs.

Histodil CoA

A Histodil CoA (Certificate of Analysis) is a formal document that attests to Histodil's compliance with Histodil specifications and serves as a tool for batch-level quality control.

Histodil CoA mostly includes findings from lab analyses of a specific batch. For each Histodil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Histodil may be tested according to a variety of international standards, such as European Pharmacopoeia (Histodil EP), Histodil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Histodil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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