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Chemistry

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Also known as: 520-26-3, Cirantin, Hesperidoside, Hesperetin 7-rhamnoglucoside, Hesperidine, Hesper bitabs
Molecular Formula
C28H34O15
Molecular Weight
610.6  g/mol
InChI Key
QUQPHWDTPGMPEX-QJBIFVCTSA-N
FDA UNII
E750O06Y6O

Hesperidin
A flavanone glycoside found in CITRUS fruit peels.
1 2D Structure

Hesperidin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
2.1.2 InChI
InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
2.1.3 InChI Key
QUQPHWDTPGMPEX-QJBIFVCTSA-N
2.1.4 Canonical SMILES
CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
2.1.5 Isomeric SMILES
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
2.2 Other Identifiers
2.2.1 UNII
E750O06Y6O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2s, Hesperidin

2. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (s)-

3. 7-rhamnoglucoside, Hesperetin

4. Hesperetin 7 Rhamnoglucoside

5. Hesperetin 7 Rutinoside

6. Hesperetin 7-rhamnoglucoside

7. Hesperetin-7-rutinoside

8. Hesperidin 2s

2.3.2 Depositor-Supplied Synonyms

1. 520-26-3

2. Cirantin

3. Hesperidoside

4. Hesperetin 7-rhamnoglucoside

5. Hesperidine

6. Hesper Bitabs

7. Ciratin

8. (s)-(-)-hesperidin

9. Hesperetin 7-rutinoside

10. Nsc 44184

11. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one

12. Hesperetin-7-rutinoside

13. Mls001304066

14. Hesperetin 7-o-rutinoside

15. Chebi:28775

16. Hesperitin-7-rhamnoglucoside

17. E750o06y6o

18. Hesperidin (jan)

19. (s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-((((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)methyl)tetrahydro-2h-pyran-2-yl)oxy)chroman-4-one

20. Hesperetin-rutinosid

21. Smr000718775

22. Hesperidin [jan]

23. Mfcd00075663

24. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2h-chromen-7-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside

25. (s)-7-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

26. Aurantiamarin (methyl Hesperidin)

27. (2s)-hesperidin

28. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chroman-4-one

29. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-({[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2h-1-benzopyran-4-one

30. Ccris 3940

31. Hesperitin-7-rutinoside

32. Sr-01000799145

33. Einecs 208-288-1

34. Brn 0075140

35. Unii-e750o06y6o

36. Hesperetin-7-o-rhamnoglucoside

37. Nsc-44184

38. Hesperidin,(s)

39. Ncgc00016481-01

40. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2h-chromen-7-yl 6-o-(6-deoxy-a-l-mannopyranosyl)-ss-d-glucopyranoside

41. (2s)-7-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4h-1-benzopyran-4-one (hesperidin)

42. (s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(((2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)methyl)tetrahydro-2h-pyran-2-yloxy)chroman-4-one

43. Cas-520-26-3

44. C28h34o15

45. Diosvein

46. Hesperiden Powder

47. 3',5'-dihydroxy-4'-methoxy-7-rutinosyloxyflavan-4-on

48. Diosmin Ep Impurity B

49. Hesperidin, >=80%

50. Hesperidin [mi]

51. Diosmin [ndi]

52. Prestwick3_000400

53. Hesperidin [inci]

54. Hesperidin [vandf]

55. Ec 208-288-1

56. Glucopyranoside, Hesperetin-7 6-o-(6-deoxy-alpha-l-mannopyranosyl)-, Beta-d-

57. Hesperetin, 7-(6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside)

58. Hesperidin [mart.]

59. Dsstox_cid_24328

60. Dsstox_rid_80154

61. Hesperidin [usp-rs]

62. Hesperidin [who-dd]

63. Dsstox_gsid_44328

64. Schembl94586

65. Bspbio_000619

66. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (s)-

67. 5-18-05-00218 (beilstein Handbook Reference)

68. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-o-alpha-l-rhamnopyranosyl-beta-d-glucopyranosyl)oxy)-4-chromanon

69. 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one, (s)-

70. 7-(6-o-desoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanon

71. Cid_10621

72. Hesperidin, Analytical Standard

73. Bpbio1_000681

74. Chembl449317

75. Ndi 590 [fdms]

76. Dtxsid9044328

77. Bcbcmap01_000136

78. Bdbm61776

79. 2h-pyran-2-yloxy)chroman-4-one

80. Hms2096o21

81. Hms2233i03

82. Hms3713o21

83. Zinc8143568

84. Tox21_110448

85. S2309

86. Akos015895450

87. Ccg-208580

88. Cs-5631

89. Db04703

90. Ks-5308

91. Smp1_000149

92. Ncgc00179501-01

93. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2s)-

94. Hy-15337

95. Ab00513829

96. H0049

97. C09755

98. D01038

99. (s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-

100. Q385937

101. Hesperidin, Primary Pharmaceutical Reference Standard

102. Methyltetrahydro-2h-pyran-2-yloxy)methyl)tetrahydro-

103. Sr-01000799145-4

104. Sr-01000799145-5

105. Sr-01000799145-7

106. 7-((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-

107. Brd-k38903228-001-02-8

108. Brd-k38903228-001-13-5

109. Hesperidin, European Pharmacopoeia (ep) Reference Standard

110. 3',5'-dihydroxy-4'-methoxy-7-rutinosyloxyflavan-4-one

111. Hesperetin 7-(6-o-alpha-l-rhamnopyranosyl)-beta-d-glucopyranoside

112. Hesperidin, Pharmaceutical Secondary Standard; Certified Reference Material

113. Flavanone, 3',5,7-trihydroxy-4'-methoxy-, 7-(6-o-alpha-l-rhamnosyl-d-glucoside)

114. (2s)-2-(4-methoxy-3-oxidanyl-phenyl)-7-[(2s,3r,4s,5s,6r)-6-[[(2r,3r,4r,5r,6s)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-oxidanyl-2,3-dihydrochromen-4-one

115. (2s)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-3,4-dihydro-2h-1-benzopyran-4-one

116. (2s)-7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

117. (s)-7-[[6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

118. 4h-1-benzopyran-4-one, 7-((6-o-(6-deoxy-.alpha.-l-mannopyranosyl)-.beta.-d-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (s)-

119. 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-o-.alpha.-l-rhamnopyranosyl-.beta.-d-glucopyranosyl)oxy)-4-chromanon

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 610.6 g/mol
Molecular Formula C28H34O15
XLogP3-1.1
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count15
Rotatable Bond Count7
Exact Mass610.18977037 g/mol
Monoisotopic Mass610.18977037 g/mol
Topological Polar Surface Area234 Ų
Heavy Atom Count43
Formal Charge0
Complexity940
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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C.,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736361000,"product":"DIOSMIN (MICRONIZED PURIFIED FLAVONOID FRACTION DIOSMIN 90 PERCENT AND FLAVONOIDS EXPRESSED AS HESPERIDIN 10 PERCENT)DIOSMIN (MICRONIZED PURIFIED FLAVONOID FRACTION DIOSMIN 90 P","address":"1003-GIDC,","city":"DIST.SURENDRANAGAR\/GUJARAT","supplier":"CHENGDU YAZHONG BIO PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MEPRO PHARMACEUTICALS PRIVATE LTD","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"41","totalValueFC":"2058.8","currency":"USD","unitRateINR":"3550.6","date":"09-Jan-2025","totalValueINR":"177530","totalValueInUsd":"2058.8","indian_port":"JNPT","hs_no":"29389090","bill_no":"7703032","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Micronized","supplierPort":"SHANGHAI","supplierAddress":"NO.342, LIRONG STR, LICHUN TOWN, PE NGZHOU CITY, SICHUAN PROVINCE, CHI NA 611936 CHINA","customerAddress":"1003-GIDC,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1744396200,"product":"HESPERIDIN (NATURAL) HESPERIDIN (NATURAL)","address":"430, DLF TOWERS,","city":"NEW DELHI","supplier":"HUNAN YUANTONG PHARMACEUTICAL COLTD","supplierCountry":"CHINA","foreign_port":"CHANGSHA","customer":"XL LABORATORIES PRIVATE LTD","customerCountry":"INDIA","quantity":"36.50","actualQuantity":"36.5","unit":"KGS","unitRateFc":"26","totalValueFC":"961.5","currency":"USD","unitRateINR":"2255.1","date":"12-Apr-2025","totalValueINR":"82309.84","totalValueInUsd":"961.5","indian_port":"Delhi Air","hs_no":"29389090","bill_no":"9462965","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHANGSHA","supplierAddress":"NO.747, KANGWAN ROAD,LIUYANG ECONOMIC DEVELOPMENT ZONE,CHANGSHA CITY, HUNAN PROVINCE P.R., CHINA","customerAddress":"430, DLF TOWERS,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q2","strtotime":1747938600,"product":"RM514 NEOHESPERIDINE DIHYDROCHALCONE CAS NO.: 20702-77-6 BATCH NO.: 25042971645RM514 NEOHESPERIDINE DIHYDROCHALCONE CAS NO.: 20702-77-6 BAT","address":"103 104,ANTARIKSH,MAROL,MAKWANA,","city":"ANDHERI EAST MUMBAI, MAHARASHTRA","supplier":"QINGDAO FREE TRADE ZONE UNITED INTERNATIONAL CO","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SENSIENT INDIA PRIVATE LTD","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"230","totalValueFC":"1166.2","currency":"USD","unitRateINR":"19872","date":"23-May-2025","totalValueINR":"99360","totalValueInUsd":"1166.2","indian_port":"Bombay Air","hs_no":"29145000","bill_no":"2237671","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"18F, Huaren, International, Buildin g 2A Shandong Road, Qingdao, China, 266071 ., , China China","customerAddress":"103 104,ANTARIKSH,MAROL,MAKWANA,"}]
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23-May-2025
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ABOUT THIS PAGE

Looking for 520-26-3 / Hesperidin API manufacturers, exporters & distributors?

Hesperidin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Hesperidin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Hesperidin manufacturer or Hesperidin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Hesperidin manufacturer or Hesperidin supplier.

PharmaCompass also assists you with knowing the Hesperidin API Price utilized in the formulation of products. Hesperidin API Price is not always fixed or binding as the Hesperidin Price is obtained through a variety of data sources. The Hesperidin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Hesperidin

Synonyms

520-26-3, Cirantin, Hesperidoside, Hesperetin 7-rhamnoglucoside, Hesperidine, Hesper bitabs

Cas Number

520-26-3

Unique Ingredient Identifier (UNII)

E750O06Y6O

About Hesperidin

A flavanone glycoside found in CITRUS fruit peels.

Hesperidin Manufacturers

A Hesperidin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Hesperidin, including repackagers and relabelers. The FDA regulates Hesperidin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Hesperidin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Hesperidin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Hesperidin Suppliers

A Hesperidin supplier is an individual or a company that provides Hesperidin active pharmaceutical ingredient (API) or Hesperidin finished formulations upon request. The Hesperidin suppliers may include Hesperidin API manufacturers, exporters, distributors and traders.

click here to find a list of Hesperidin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Hesperidin USDMF

A Hesperidin DMF (Drug Master File) is a document detailing the whole manufacturing process of Hesperidin active pharmaceutical ingredient (API) in detail. Different forms of Hesperidin DMFs exist exist since differing nations have different regulations, such as Hesperidin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Hesperidin DMF submitted to regulatory agencies in the US is known as a USDMF. Hesperidin USDMF includes data on Hesperidin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Hesperidin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Hesperidin suppliers with USDMF on PharmaCompass.

Hesperidin GMP

Hesperidin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Hesperidin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Hesperidin GMP manufacturer or Hesperidin GMP API supplier for your needs.

Hesperidin CoA

A Hesperidin CoA (Certificate of Analysis) is a formal document that attests to Hesperidin's compliance with Hesperidin specifications and serves as a tool for batch-level quality control.

Hesperidin CoA mostly includes findings from lab analyses of a specific batch. For each Hesperidin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Hesperidin may be tested according to a variety of international standards, such as European Pharmacopoeia (Hesperidin EP), Hesperidin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Hesperidin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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