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Chemistry

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Also known as: 74050-97-8, Halomonth, Haldol decanoate, Neoperidole, Kd 136, Kd 16
Molecular Formula
C31H41ClFNO3
Molecular Weight
530.1  g/mol
InChI Key
GUTXTARXLVFHDK-UHFFFAOYSA-N
FDA UNII
AC20PJ4101

Haloperidol Decanoate
Haloperidol Decanoate is the decanoate ester of haloperidol, a phenylbutylpiperadine derivative with antipsychotic, neuroleptic and antiemetic effects. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain leading to anti-delusionary and anti-hallucinogenic effects. The antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) account for its antiemetic activity.
1 2D Structure

Haloperidol Decanoate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] decanoate
2.1.2 InChI
InChI=1S/C31H41ClFNO3/c1-2-3-4-5-6-7-8-11-30(36)37-31(26-14-16-27(32)17-15-26)20-23-34(24-21-31)22-9-10-29(35)25-12-18-28(33)19-13-25/h12-19H,2-11,20-24H2,1H3
2.1.3 InChI Key
GUTXTARXLVFHDK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCCCCCCCC(=O)OC1(CCN(CC1)CCCC(=O)C2=CC=C(C=C2)F)C3=CC=C(C=C3)Cl
2.2 Other Identifiers
2.2.1 UNII
AC20PJ4101
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 74050-97-8

2. Halomonth

3. Haldol Decanoate

4. Neoperidole

5. Kd 136

6. Kd 16

7. Kd-136

8. [4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] Decanoate

9. Ac20pj4101

10. R-13672

11. R-13,672

12. 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)piperidin-4-yl Decanoate

13. Decanoic Acid, Ester With 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone

14. Haldol Decanoas

15. Decanoic Acid, 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl Ester

16. Depot Haloperidol

17. Haloperidol Depot

18. Halomonth; Haloperidol Decanoate; Kd 136; Kd 16; Neoperidole; R 13762

19. Einecs 277-679-7

20. Haloperidol Decanoate Hcl

21. Unii-ac20pj4101

22. Haldol Dec

23. L-ornithineacetate

24. Halomonth (tn)

25. R 13672

26. Haloperidol-decanoate

27. R 13,672

28. Haloperidol Decanoate [usan:usp:ban:jan]

29. Schembl120575

30. Chembl1200986

31. Chebi:31664

32. Dtxsid50224951

33. Haloperidol Decanoate (jan/usp)

34. Haloperidol Decanoate [mi]

35. Hms3887c07

36. Haloperidol Decanoate [jan]

37. Zinc8214574

38. Haloperidol Decanoate [usan]

39. Bdbm50053408

40. Haloperidol Decanoate [mart.]

41. 4-(4-chlorophenyl)-1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidyl Decanoate

42. Akos025392169

43. Haloperidol Decanoate [usp-rs]

44. Haloperidol Decanoate [who-dd]

45. Ks-1419

46. Ncgc00508704-02

47. Haloperidol Decanoate [ep Impurity]

48. Haloperidol Decanoate [orange Book]

49. Haloperidol Decanoate [ep Monograph]

50. Haloperidol Decanoate [usp Impurity]

51. Hy-107969

52. Cs-0031068

53. Ft-0669103

54. Haloperidol Decanoate [usp Monograph]

55. D01898

56. Q27273855

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 530.1 g/mol
Molecular Formula C31H41ClFNO3
XLogP37.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Exact Mass529.2759000 g/mol
Monoisotopic Mass529.2759000 g/mol
Topological Polar Surface Area46.6 Ų
Heavy Atom Count37
Formal Charge0
Complexity665
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameHaloperidol decanoate
PubMed HealthHaloperidol Decanoate (Injection)
Drug ClassesAntipsychotic
Drug LabelHaloperidol decanoate USP is the decanoate ester of the butyrophenone, haloperidol. It has a markedly extended duration of effect. It is available in sesame oil in sterile form for intramuscular (IM) injection. The structural formula of haloperidol d...
Active IngredientHaloperidol decanoate
Dosage FormInjectable
RouteInjection
Strengtheq 50mg base/ml; eq 100mg base/ml
Market StatusPrescription
CompanyTeva Pharms Usa; Fresenius Kabi Usa; Eurohlth Intl; Agila Speclts

2 of 2  
Drug NameHaloperidol decanoate
PubMed HealthHaloperidol Decanoate (Injection)
Drug ClassesAntipsychotic
Drug LabelHaloperidol decanoate USP is the decanoate ester of the butyrophenone, haloperidol. It has a markedly extended duration of effect. It is available in sesame oil in sterile form for intramuscular (IM) injection. The structural formula of haloperidol d...
Active IngredientHaloperidol decanoate
Dosage FormInjectable
RouteInjection
Strengtheq 50mg base/ml; eq 100mg base/ml
Market StatusPrescription
CompanyTeva Pharms Usa; Fresenius Kabi Usa; Eurohlth Intl; Agila Speclts

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Typical Antipsychotic [EPC]

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27-Jan-2022
29-Apr-2025
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ABOUT THIS PAGE

Looking for 74050-97-8 / Haloperidol Decanoate API manufacturers, exporters & distributors?

Haloperidol Decanoate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Haloperidol Decanoate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Haloperidol Decanoate manufacturer or Haloperidol Decanoate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Haloperidol Decanoate manufacturer or Haloperidol Decanoate supplier.

PharmaCompass also assists you with knowing the Haloperidol Decanoate API Price utilized in the formulation of products. Haloperidol Decanoate API Price is not always fixed or binding as the Haloperidol Decanoate Price is obtained through a variety of data sources. The Haloperidol Decanoate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Haloperidol Decanoate

Synonyms

74050-97-8, Halomonth, Haldol decanoate, Neoperidole, Kd 136, Kd 16

Cas Number

74050-97-8

Unique Ingredient Identifier (UNII)

AC20PJ4101

About Haloperidol Decanoate

Haloperidol Decanoate is the decanoate ester of haloperidol, a phenylbutylpiperadine derivative with antipsychotic, neuroleptic and antiemetic effects. Haloperidol competitively blocks postsynaptic dopamine (D2) receptors in the mesolimbic system of the brain leading to anti-delusionary and anti-hallucinogenic effects. The antagonistic activity mediated through D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) account for its antiemetic activity.

Haloperidol Decanoate Manufacturers

A Haloperidol Decanoate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Haloperidol Decanoate, including repackagers and relabelers. The FDA regulates Haloperidol Decanoate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Haloperidol Decanoate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Haloperidol Decanoate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Haloperidol Decanoate Suppliers

A Haloperidol Decanoate supplier is an individual or a company that provides Haloperidol Decanoate active pharmaceutical ingredient (API) or Haloperidol Decanoate finished formulations upon request. The Haloperidol Decanoate suppliers may include Haloperidol Decanoate API manufacturers, exporters, distributors and traders.

click here to find a list of Haloperidol Decanoate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Haloperidol Decanoate USDMF

A Haloperidol Decanoate DMF (Drug Master File) is a document detailing the whole manufacturing process of Haloperidol Decanoate active pharmaceutical ingredient (API) in detail. Different forms of Haloperidol Decanoate DMFs exist exist since differing nations have different regulations, such as Haloperidol Decanoate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Haloperidol Decanoate DMF submitted to regulatory agencies in the US is known as a USDMF. Haloperidol Decanoate USDMF includes data on Haloperidol Decanoate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Haloperidol Decanoate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Haloperidol Decanoate suppliers with USDMF on PharmaCompass.

Haloperidol Decanoate CEP

A Haloperidol Decanoate CEP of the European Pharmacopoeia monograph is often referred to as a Haloperidol Decanoate Certificate of Suitability (COS). The purpose of a Haloperidol Decanoate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Haloperidol Decanoate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Haloperidol Decanoate to their clients by showing that a Haloperidol Decanoate CEP has been issued for it. The manufacturer submits a Haloperidol Decanoate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Haloperidol Decanoate CEP holder for the record. Additionally, the data presented in the Haloperidol Decanoate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Haloperidol Decanoate DMF.

A Haloperidol Decanoate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Haloperidol Decanoate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Haloperidol Decanoate suppliers with CEP (COS) on PharmaCompass.

Haloperidol Decanoate WC

A Haloperidol Decanoate written confirmation (Haloperidol Decanoate WC) is an official document issued by a regulatory agency to a Haloperidol Decanoate manufacturer, verifying that the manufacturing facility of a Haloperidol Decanoate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Haloperidol Decanoate APIs or Haloperidol Decanoate finished pharmaceutical products to another nation, regulatory agencies frequently require a Haloperidol Decanoate WC (written confirmation) as part of the regulatory process.

click here to find a list of Haloperidol Decanoate suppliers with Written Confirmation (WC) on PharmaCompass.

Haloperidol Decanoate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Haloperidol Decanoate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Haloperidol Decanoate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Haloperidol Decanoate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Haloperidol Decanoate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Haloperidol Decanoate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Haloperidol Decanoate suppliers with NDC on PharmaCompass.

Haloperidol Decanoate GMP

Haloperidol Decanoate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Haloperidol Decanoate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Haloperidol Decanoate GMP manufacturer or Haloperidol Decanoate GMP API supplier for your needs.

Haloperidol Decanoate CoA

A Haloperidol Decanoate CoA (Certificate of Analysis) is a formal document that attests to Haloperidol Decanoate's compliance with Haloperidol Decanoate specifications and serves as a tool for batch-level quality control.

Haloperidol Decanoate CoA mostly includes findings from lab analyses of a specific batch. For each Haloperidol Decanoate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Haloperidol Decanoate may be tested according to a variety of international standards, such as European Pharmacopoeia (Haloperidol Decanoate EP), Haloperidol Decanoate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Haloperidol Decanoate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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