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Chemistry

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Also known as: 1702259-66-2, N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide, 4hte364xik, N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide, 2-propenamide, n-(2-((6-((((2,6-dichloro-3,5-dimethoxyphenyl)amino)carbonyl)methylamino)-4-pyrimidinyl)amino)-5-(4-ethyl-1-piperazinyl)phenyl)-, N-(2-((6-(((2,6-dichloro-3,5 dimethoxyphenyl) carbamoyl) (methyl)amino)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)prop-2-enamide
Molecular Formula
C29H34Cl2N8O4
Molecular Weight
629.5  g/mol
InChI Key
MBWRLLRCTIYXDW-UHFFFAOYSA-N
FDA UNII
4HTE364XIK

H3B-6527
FGFR4 Inhibitor H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.
1 2D Structure

H3B-6527

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide
2.1.2 InChI
InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
2.1.3 InChI Key
MBWRLLRCTIYXDW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN1CCN(CC1)C2=CC(=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl)NC(=O)C=C
2.2 Other Identifiers
2.2.1 UNII
4HTE364XIK
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1702259-66-2

2. N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide

3. 4hte364xik

4. N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide

5. 2-propenamide, N-(2-((6-((((2,6-dichloro-3,5-dimethoxyphenyl)amino)carbonyl)methylamino)-4-pyrimidinyl)amino)-5-(4-ethyl-1-piperazinyl)phenyl)-

6. N-(2-((6-(((2,6-dichloro-3,5 Dimethoxyphenyl) Carbamoyl) (methyl)amino)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)prop-2-enamide

7. Unii-4hte364xik

8. Chembl3939295

9. Schembl16659467

10. Bdbm249396

11. Amy16703

12. Bcp17555

13. Ctc25966

14. Ex-a1510

15. H3b 6527 [who-dd]

16. H3b 6527

17. Nsc800283

18. S8675

19. Akos032960479

20. Zinc521836463

21. Ccg-270286

22. Cs-5830

23. Db15169

24. H3b6527

25. Nsc-800283

26. Sb40408

27. Ac-29878

28. As-55996

29. Hy-100491

30. H3b 6527;h3b6527;eisai;h3 Biomedicine

31. A901400

32. Us9434697, 108

33. N-(2-(6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-ylamino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide

34. N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpi

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 629.5 g/mol
Molecular Formula C29H34Cl2N8O4
XLogP34.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass628.2080070 g/mol
Monoisotopic Mass628.2080070 g/mol
Topological Polar Surface Area124 Ų
Heavy Atom Count43
Formal Charge0
Complexity913
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1702259-66-2 / H3B-6527 API manufacturers, exporters & distributors?

H3B-6527 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of H3B-6527 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right H3B-6527 manufacturer or H3B-6527 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred H3B-6527 manufacturer or H3B-6527 supplier.

PharmaCompass also assists you with knowing the H3B-6527 API Price utilized in the formulation of products. H3B-6527 API Price is not always fixed or binding as the H3B-6527 Price is obtained through a variety of data sources. The H3B-6527 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

H3B-6527

Synonyms

1702259-66-2, N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin-1-yl)phenyl]prop-2-enamide, 4hte364xik, N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide, 2-propenamide, n-(2-((6-((((2,6-dichloro-3,5-dimethoxyphenyl)amino)carbonyl)methylamino)-4-pyrimidinyl)amino)-5-(4-ethyl-1-piperazinyl)phenyl)-, N-(2-((6-(((2,6-dichloro-3,5 dimethoxyphenyl) carbamoyl) (methyl)amino)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)prop-2-enamide

Cas Number

1702259-66-2

Unique Ingredient Identifier (UNII)

4HTE364XIK

About H3B-6527

FGFR4 Inhibitor H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.

H3b 6527 Manufacturers

A H3b 6527 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of H3b 6527, including repackagers and relabelers. The FDA regulates H3b 6527 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. H3b 6527 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

H3b 6527 Suppliers

A H3b 6527 supplier is an individual or a company that provides H3b 6527 active pharmaceutical ingredient (API) or H3b 6527 finished formulations upon request. The H3b 6527 suppliers may include H3b 6527 API manufacturers, exporters, distributors and traders.

H3b 6527 GMP

H3b 6527 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of H3b 6527 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right H3b 6527 GMP manufacturer or H3b 6527 GMP API supplier for your needs.

H3b 6527 CoA

A H3b 6527 CoA (Certificate of Analysis) is a formal document that attests to H3b 6527's compliance with H3b 6527 specifications and serves as a tool for batch-level quality control.

H3b 6527 CoA mostly includes findings from lab analyses of a specific batch. For each H3b 6527 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

H3b 6527 may be tested according to a variety of international standards, such as European Pharmacopoeia (H3b 6527 EP), H3b 6527 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (H3b 6527 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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