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Granisetron Hydrochloride

Granisetron Hydrochloride

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Also known as: Granisetron hcl, 107007-99-8, Granisetron (hydrochloride), Nsc-759839, 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride, 1-methyl-1h-indazole-3-carboxylic acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide hydrochloride

Molecular Formula

C₁₈H₂₅ClN₄O

Molecular Weight

348.9 g/mol

InChI Key

QYZRTBKYBJRGJB-UHFFFAOYSA-N

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.

1 2D Structure

Granisetron Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H

2.1.3 InChI Key

QYZRTBKYBJRGJB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 1-methyl-n-(endo-9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1h-indazole-3-carboxamide

2. 1h-indazole-3-carboxamide, 1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl

3. 1h-indazole-3-carboxamide, 1-methyl-n-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, Endo-

4. Brl 43694

5. Brl 43694a

6. Brl-43694

7. Brl-43694a

8. Brl43694

9. Brl43694a

10. Granisetron

11. Granisetron Monohydrochloride

12. Hydrochloride, Granisetron

13. Kytril

14. Monohydrochloride, Granisetron

2.2.2 Depositor-Supplied Synonyms

1. Granisetron Hcl

2. 107007-99-8

3. Granisetron (hydrochloride)

4. Nsc-759839

5. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride

6. 1-methyl-1h-indazole-3-carboxylic Acid (9-methyl-9-aza-bicyclo[3.3.1]non-3-yl)-amide Hydrochloride

7. Bema Granisetron

8. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1h-indazole-3-carboxamide Hydrochloride

9. 1-methyl-n-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1h-indazole-3-carboxamide Hydrochloride

10. Granisetronhydrochloride

11. Granisetron (as Hydrochloride)

12. C18h24n4o.hcl

13. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide Hydrochloride

14. Schembl33433

15. Mls003915623

16. Chembl1237080

17. Hy-b0071a

18. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide Hydrochloride

19. Brl-43694a

20. Pharmakon1600-01502365

21. Bcp02186

22. Tox21_501173

23. Ac-478

24. Mfcd21091183

25. Nsc672814

26. Nsc759839

27. S1345

28. Akos015894931

29. Ab53971

30. Ccg-213056

31. Cs-1510

32. Lp01173

33. Nsc-672814

34. 1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide Hcl

35. Ncgc00261858-01

36. 1044956-47-9

37. As-12882

38. Smr001456513

39. Ft-0626806

40. J-001688

2.3 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₅ClN₄O
Molecular Weight	348.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	348.1716891 g/mol
Monoisotopic Mass	348.1716891 g/mol
Topological Polar Surface Area	50.2 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	442
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Granisetron hydrochloride
Drug Label	Granisetron Hydrochloride Tablets USP contain granisetron hydrochloride USP, an antinauseant and antiemetic agent. Chemically it is endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride with a molecular weig...
Active Ingredient	Granisetron hydrochloride
Dosage Form	Tablet; Injectable
Route	injection; Injection; Oral
Strength	1mg/ml; eq 0.1mg base/ml (eq 0.1mg base/ml); eq 4mg base/4ml (eq 1mg base/ml); eq 1mg base; eq 1mg base/ml (eq 1mg base/ml)
Market Status	Prescription
Company	Corepharma; Sagent Strides; Dsm Pharms; Apotex; Natco Pharma; Teva Pharms Usa; Taro; Banner Pharmacaps; Sandoz; Cipla; Roxane; Sagent Agila; Teva Pharms; Fresenius Kabi Usa; Hikma Maple; Luitpold; Bedford Labs; Dr Reddys Labs; Wockhardt Usa; Mylan; Orchid

2 of 2
Drug Name	Granisetron hydrochloride
Drug Label	Granisetron Hydrochloride Tablets USP contain granisetron hydrochloride USP, an antinauseant and antiemetic agent. Chemically it is endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride with a molecular weig...
Active Ingredient	Granisetron hydrochloride
Dosage Form	Tablet; Injectable
Route	injection; Injection; Oral
Strength	1mg/ml; eq 0.1mg base/ml (eq 0.1mg base/ml); eq 4mg base/4ml (eq 1mg base/ml); eq 1mg base; eq 1mg base/ml (eq 1mg base/ml)
Market Status	Prescription
Company	Corepharma; Sagent Strides; Dsm Pharms; Apotex; Natco Pharma; Teva Pharms Usa; Taro; Banner Pharmacaps; Sandoz; Cipla; Roxane; Sagent Agila; Teva Pharms; Fresenius Kabi Usa; Hikma Maple; Luitpold; Bedford Labs; Dr Reddys Labs; Wockhardt Usa; Mylan; Orchid

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Serotonin 5-HT3 Receptor Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS. (See all compounds classified as Serotonin 5-HT3 Receptor Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Serotonin-3 Receptor Antagonist [EPC]; Serotonin 3 Receptor Antagonists [MoA]