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Chemistry

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Also known as: Glecirasib, Kras g12c inhibitor 62, Glecirasib [inn], Up75wh4qkm, Schembl23830094, Ex-a8185q
Molecular Formula
C31H26ClF4N7O2
Molecular Weight
640.0  g/mol
InChI Key
QRRJEUIQLZNPIO-UHFFFAOYSA-N
FDA UNII
UP75WH4QKM

Glecirasib
Glecirasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, glecirasib selectively targets, binds to and inhibits the activity of the KRAS G12C mutant, thereby inhibiting KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.
1 2D Structure

Glecirasib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-(2-amino-3,4,5,6-tetrafluorophenyl)-6-chloro-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-2-oxo-4-(4-prop-2-enoylpiperazin-1-yl)-1,8-naphthyridine-3-carbonitrile
2.1.2 InChI
InChI=1S/C31H26ClF4N7O2/c1-5-19(44)41-8-10-42(11-9-41)29-16-12-18(32)27(20-21(33)22(34)23(35)24(36)25(20)38)40-30(16)43(31(45)17(29)13-37)28-15(4)6-7-39-26(28)14(2)3/h5-7,12,14H,1,8-11,38H2,2-4H3
2.1.3 InChI Key
QRRJEUIQLZNPIO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C(=NC=C1)C(C)C)N2C3=NC(=C(C=C3C(=C(C2=O)C#N)N4CCN(CC4)C(=O)C=C)Cl)C5=C(C(=C(C(=C5F)F)F)F)N
2.2 Other Identifiers
2.2.1 UNII
UP75WH4QKM
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Glecirasib

2. Kras G12c Inhibitor 62

3. Glecirasib [inn]

4. Up75wh4qkm

5. Schembl23830094

6. Ex-a8185q

7. Hy-143589

8. Hy-157067

9. Cs-0373885

10. Cs-0904896

11. 2657613-87-9

12. 2658588-10-2

2.4 Create Date
2021-12-03
3 Chemical and Physical Properties
Molecular Weight 640.0 g/mol
Molecular Formula C31H26ClF4N7O2
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area119
Heavy Atom Count45
Formal Charge0
Complexity1240
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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Looking for / Glecirasib API manufacturers, exporters & distributors?

Glecirasib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Glecirasib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Glecirasib manufacturer or Glecirasib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Glecirasib manufacturer or Glecirasib supplier.

PharmaCompass also assists you with knowing the Glecirasib API Price utilized in the formulation of products. Glecirasib API Price is not always fixed or binding as the Glecirasib Price is obtained through a variety of data sources. The Glecirasib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Glecirasib

Synonyms

Kras g12c inhibitor 62, Glecirasib [inn], Up75wh4qkm, Schembl23830094, Ex-a8185q, Hy-143589

Unique Ingredient Identifier (UNII)

UP75WH4QKM

About Glecirasib

Glecirasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, glecirasib selectively targets, binds to and inhibits the activity of the KRAS G12C mutant, thereby inhibiting KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

Glecirasib Manufacturers

A Glecirasib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Glecirasib, including repackagers and relabelers. The FDA regulates Glecirasib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Glecirasib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Glecirasib Suppliers

A Glecirasib supplier is an individual or a company that provides Glecirasib active pharmaceutical ingredient (API) or Glecirasib finished formulations upon request. The Glecirasib suppliers may include Glecirasib API manufacturers, exporters, distributors and traders.

Glecirasib GMP

Glecirasib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Glecirasib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Glecirasib GMP manufacturer or Glecirasib GMP API supplier for your needs.

Glecirasib CoA

A Glecirasib CoA (Certificate of Analysis) is a formal document that attests to Glecirasib's compliance with Glecirasib specifications and serves as a tool for batch-level quality control.

Glecirasib CoA mostly includes findings from lab analyses of a specific batch. For each Glecirasib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Glecirasib may be tested according to a variety of international standards, such as European Pharmacopoeia (Glecirasib EP), Glecirasib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Glecirasib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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