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Chemistry

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Also known as: 199657-29-9, Givinostat hcl, Givinostat (hydrochloride), Itf 2357, Z02132r2qq, Unii-z02132r2qq
Molecular Formula
C24H28ClN3O4
Molecular Weight
457.9  g/mol
InChI Key
QKSGNWJOQMSBEP-UHFFFAOYSA-N
FDA UNII
Z02132R2QQ

Givinostat HCl
Histone Deacetylase Inhibitor is any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation.
1 2D Structure

Givinostat HCl

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrochloride
2.1.2 InChI
InChI=1S/C24H27N3O4.ClH/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30;/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28);1H
2.1.3 InChI Key
QKSGNWJOQMSBEP-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
Z02132R2QQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Itf 2357

2. Itf2357

2.3.2 Depositor-Supplied Synonyms

1. 199657-29-9

2. Givinostat Hcl

3. Givinostat (hydrochloride)

4. Itf 2357

5. Z02132r2qq

6. Unii-z02132r2qq

7. Itf2357 Hydrochloride

8. Itf-2357 Hydrochloride

9. Histone Deacetylase Inhibitor

10. Itf2357

11. Itf-2357

12. Carbamic Acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl Ester, Hydrochloride (1:1)

13. [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrochloride

14. Carbamic Acid, N-(4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl Ester, Hydrochloride (1:1)

15. (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate Hydrochloride

16. Mfcd28502062

17. {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate Hydrochloride

18. Itf 2357 Hydrochloride

19. Givinostat Monohydrochloride

20. Schembl23529420

21. Givinostat Hydrochloride Anhydrous

22. Chebi:231333

23. Ex-a8024

24. Zha65729

25. Hy-14842a

26. Akos030526700

27. Cs-4728

28. Sb16937

29. As-52365

30. En300-257964

31. P14959

32. Q27294820

33. Z2327390266

34. (6-((diethylamino)methyl)naphthalen-2-yl)methyl 4-(hydroxycarbamoyl)phenylcarbamate Hydrochloride

35. [6-[(diethylamino)methyl]-2-naphthalenyl]methyl N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate Hydrochloride (1:1)

36. {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate--hydrogen Chloride

37. {6-[(diethylamino)methyl]naphthalen-2-yl}methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate Hydrochloride

2.3.3 Other Synonyms

1. Givinostat

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 457.9 g/mol
Molecular Formula C24H28ClN3O4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area90.9
Heavy Atom Count32
Formal Charge0
Complexity575
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histone Deacetylase Inhibitors

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)


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ABOUT THIS PAGE

Looking for 199657-29-9 / Givinostat HCl API manufacturers, exporters & distributors?

Givinostat HCl manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Givinostat HCl API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Givinostat HCl manufacturer or Givinostat HCl supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Givinostat HCl manufacturer or Givinostat HCl supplier.

PharmaCompass also assists you with knowing the Givinostat HCl API Price utilized in the formulation of products. Givinostat HCl API Price is not always fixed or binding as the Givinostat HCl Price is obtained through a variety of data sources. The Givinostat HCl Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Givinostat HCl

Synonyms

199657-29-9, Givinostat (hydrochloride), Itf 2357, Z02132r2qq, Unii-z02132r2qq, Itf2357 hydrochloride

Cas Number

199657-29-9

Unique Ingredient Identifier (UNII)

Z02132R2QQ

About Givinostat HCl

Histone Deacetylase Inhibitor is any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation.

Givinostat HCl Manufacturers

A Givinostat HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Givinostat HCl, including repackagers and relabelers. The FDA regulates Givinostat HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Givinostat HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Givinostat HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Givinostat HCl Suppliers

A Givinostat HCl supplier is an individual or a company that provides Givinostat HCl active pharmaceutical ingredient (API) or Givinostat HCl finished formulations upon request. The Givinostat HCl suppliers may include Givinostat HCl API manufacturers, exporters, distributors and traders.

click here to find a list of Givinostat HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Givinostat HCl USDMF

A Givinostat HCl DMF (Drug Master File) is a document detailing the whole manufacturing process of Givinostat HCl active pharmaceutical ingredient (API) in detail. Different forms of Givinostat HCl DMFs exist exist since differing nations have different regulations, such as Givinostat HCl USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Givinostat HCl DMF submitted to regulatory agencies in the US is known as a USDMF. Givinostat HCl USDMF includes data on Givinostat HCl's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Givinostat HCl USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Givinostat HCl suppliers with USDMF on PharmaCompass.

Givinostat HCl GMP

Givinostat HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Givinostat HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Givinostat HCl GMP manufacturer or Givinostat HCl GMP API supplier for your needs.

Givinostat HCl CoA

A Givinostat HCl CoA (Certificate of Analysis) is a formal document that attests to Givinostat HCl's compliance with Givinostat HCl specifications and serves as a tool for batch-level quality control.

Givinostat HCl CoA mostly includes findings from lab analyses of a specific batch. For each Givinostat HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Givinostat HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Givinostat HCl EP), Givinostat HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Givinostat HCl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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