Find Gefapixant Citrate manufacturers, exporters & distributors on PharmaCompass

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ACTIVE PHARMA INGREDIENTS

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USDMF

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Chemistry

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Also known as: 1015787-98-0, Af-219, Mk-7264, Gefapixant [usan], Ro4926219, Rg-1646
Molecular Formula
C14H19N5O4S
Molecular Weight
353.40  g/mol
InChI Key
HLWURFKMDLAKOD-UHFFFAOYSA-N
FDA UNII
6K6L7E3F1L

Gefapixant Citrate
Gefapixant is under investigation in clinical trial NCT02397460 (Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity).
1 2D Structure

Gefapixant Citrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
2.1.2 InChI
InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19)
2.1.3 InChI Key
HLWURFKMDLAKOD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC
2.2 Other Identifiers
2.2.1 UNII
6K6L7E3F1L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-((2,4-diamino-5-pyrimidinyl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

2. Af-219

3. Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-

4. Mk-7264

2.3.2 Depositor-Supplied Synonyms

1. 1015787-98-0

2. Af-219

3. Mk-7264

4. Gefapixant [usan]

5. Ro4926219

6. Rg-1646

7. Ro-4926219

8. Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-

9. 6k6l7e3f1l

10. R-1646

11. Af219

12. Rg1646

13. Mk-7264;af-219

14. R1646

15. 5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide

16. C14h19n5o4s

17. 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

18. 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide

19. 5-[(2,4-diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide

20. 5-((2,4-diaminopyrimidin-5-yl)oxy)-2-methoxy-4-(propan-2-yl)benzenesulfonamide

21. 5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide

22. Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-

23. 5-((2,4-diamino-5-pyrimidinyl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide

24. Gefapixant [inn]

25. Gefapixant (usan/inn)

26. Gefapixant [who-dd]

27. Unii-6k6l7e3f1l

28. Gtpl9540

29. Schembl1493905

30. Chembl3716057

31. Dtxsid401337212

32. Amy27911

33. Bcp26079

34. Ex-a2788

35. Gefapixant(af-219,mk-7264)

36. Bdbm50533006

37. Mfcd24539325

38. S6664

39. Akos037515637

40. Zinc116342482

41. Db15097

42. Af-219; Mk-7264

43. Ac-35643

44. As-78086

45. Bm170818

46. Sy282739

47. Hy-101588

48. Cs-0021727

49. Ro 4926219

50. J3.556.891c

51. D11349

52. A934898

53. 2-methoxy-4-isopropyl-5-(2,4-diamino-5-pyrimidinyloxy)benzenesulfonamide

54. 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide

55. Af9

2.4 Create Date
2008-04-21
3 Chemical and Physical Properties
Molecular Weight 353.40 g/mol
Molecular Formula C14H19N5O4S
XLogP30.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass353.11577528 g/mol
Monoisotopic Mass353.11577528 g/mol
Topological Polar Surface Area165 Ų
Heavy Atom Count24
Formal Charge0
Complexity512
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 ATC Code

R - Respiratory system

R05 - Cough and cold preparations

R05D - Cough suppressants, excl. combinations with expectorants

R05DB - Other cough suppressants

R05DB29 - Gefapixant


API SUPPLIERS

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Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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02

Jinan Tantu Chemicals

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothJinan Tantu Chemicals offers customized R&D services & production of small molecule APIs & pharmaceutical intermediates.

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Jinan Tantu Chemicals

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Shandong Loncom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothShandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

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Beijing Mesochem Technology

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

  • fda
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  • WHO-GMP

Virtual BoothMesochem is focused on incessant innovation along with the R&D of new APIs.

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Precise Group

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Excipient World
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Glixx Laboratories

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Excipient World
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Glixx Laboratories

U.S.A

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Listed Suppliers

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Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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Gefapixant Citrate

About the Company : Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product gro...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer
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Virtual BoothJinan Tantu Chemicals offers customized R&D services & production of small molecule APIs & pharmaceutical intermediates.

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Gefapixant Citrate

About the Company : Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include c...

Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include customized R&D as well as the production of small molecule pharmaceutical intermediates and Active Pharmaceutical Ingredients (APIs) for both international and domestic pharmaceutical firms. Our capabilities span from laboratory-scale kilograms to commercial ton-scale production. Additionally, we are committed to independent research and development, as well as the production and sales of high-end pharmaceutical intermediates and API products.
Jinan Tantu Chemicals

03

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothShandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

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Gefapixant Citrate

About the Company : Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development...

Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development Zone, Shandong Province, Shandong Loncom has operational API pilot tests and production bases adhering to international standards. With 13 production lines dedicated to oral solid preparations, oral liquid preparations and API, it is actively expanding its preparation workshops for small-volume injections, soft capsules, eye drops, topical medicines and innovative drug R&D centres.
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Virtual BoothMesochem is focused on incessant innovation along with the R&D of new APIs.

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Gefapixant Citrate

About the Company : Beijing Mesochem Technology Co. Ltd., which is located in the national economic and technological development area of Yizhuang, China, manufactures pharmaceutical chemicals, fine c...

Beijing Mesochem Technology Co. Ltd., which is located in the national economic and technological development area of Yizhuang, China, manufactures pharmaceutical chemicals, fine chemicals and fundamental chemical materials. It has an efficient research and development team. Beijing Mesochem provides its customers customized development, craft optimization, contract customization and outsourcing services. The company has a well-established industrial base in Weinan, Shanxi Province. The production base features a 20,000 ㎡ plant with a production capacity of over 8,000 MT per year.
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American Thoracic Society
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Gefapixant Citrate

About the Company : Glixx Laboratories Inc (Glixx) is a global leading company specializing in biological research chemicals, providing services to meet the needs of biomedical research markets. With ...

Glixx Laboratories Inc (Glixx) is a global leading company specializing in biological research chemicals, providing services to meet the needs of biomedical research markets. With its fast and efficient synthesis, the Glixx R&D team focuses on commercializing newly discovered research chemicals and bringing them to the life sciences R&D communities. Our company goal is to help our community by lowering the cost of the essential chemicals for research needs, to better progress on to new discoveries in drug development, medical screening, and all facets of scientific innovations.
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American Thoracic Society
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Gefapixant Citrate

About the Company : Established in 1997, the PRECISE Group is a respected pharmaceutical company in India with an annual turnover of USD 40 million. Backed by a skilled regulatory team, a dedicated fo...

Established in 1997, the PRECISE Group is a respected pharmaceutical company in India with an annual turnover of USD 40 million. Backed by a skilled regulatory team, a dedicated formulation and development unit, and over 100 professionals, PRECISE has emerged as a one-stop solution for APIs, intermediates, and finished formulations. Leveraging our core strengths, we continue to strengthen our presence in the global market.
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Drugs in Development

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Details:

Lyfnua (gefapixant) is an investigational, non-narcotic, oral selective P2X3 receptor antagonist, under development for the treatment of refractory chronic cough or unexplained chronic cough in adults.


Lead Product(s): Gefapixant Citrate

Therapeutic Area: Pulmonary/Respiratory Diseases Brand Name: Lyfnua

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable December 20, 2023

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Merck & Co

U.S.A
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Merck & Co

U.S.A
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Details : Lyfnua (gefapixant) is an investigational, non-narcotic, oral selective P2X3 receptor antagonist, under development for the treatment of refractory chronic cough or unexplained chronic cough in adults.

Product Name : Lyfnua

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

December 20, 2023

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Details:

MK-7264 (gefapixant), an investigational, orally administered, selective P2X3 receptor antagonist, is being developed for the potential treatment of refractory or unexplained chronic cough and was approved in Japan and Switzerland under the brand name Lyfnua®.


Lead Product(s): Gefapixant Citrate

Therapeutic Area: Pulmonary/Respiratory Diseases Brand Name: Lyfnua

Study Phase: Approved FDFProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable July 21, 2023

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Merck & Co

U.S.A
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STLE Annual Meeting
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Merck & Co

U.S.A
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STLE Annual Meeting
Not Confirmed

Details : MK-7264 (gefapixant), an investigational, orally administered, selective P2X3 receptor antagonist, is being developed for the potential treatment of refractory or unexplained chronic cough and was approved in Japan and Switzerland under the brand name Ly...

Product Name : Lyfnua

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

July 21, 2023

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Details:

Last week, the Japan Ministry of Health, Labor and Welfare (MHLW) approved LYFNUA® (gefapixant) Tablets 45 mg for adults with refractory or unexplained chronic cough.


Lead Product(s): Gefapixant Citrate

Therapeutic Area: Pulmonary/Respiratory Diseases Brand Name: Lyfnua

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable January 24, 2022

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Merck & Co

U.S.A
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STLE Annual Meeting
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Merck & Co

U.S.A
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Details : Last week, the Japan Ministry of Health, Labor and Welfare (MHLW) approved LYFNUA® (gefapixant) Tablets 45 mg for adults with refractory or unexplained chronic cough.

Product Name : Lyfnua

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 24, 2022

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Details:

COUGH-1 and COUGH-2 are international Phase 3, randomized, double-blind, placebo-controlled, studies to evaluate the efficacy and safety of gefapixant in reducing cough frequency in adult participants with refractory or unexplained chronic cough.


Lead Product(s): Gefapixant Citrate

Therapeutic Area: Pulmonary/Respiratory Diseases Brand Name: Lyfnua

Study Phase: Phase IIIProduct Type: Other Small Molecule

Sponsor: Inapplicable

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable August 09, 2020

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Merck & Co

U.S.A
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STLE Annual Meeting
Not Confirmed

Merck & Co

U.S.A
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STLE Annual Meeting
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Details : COUGH-1 and COUGH-2 are international Phase 3, randomized, double-blind, placebo-controlled, studies to evaluate the efficacy and safety of gefapixant in reducing cough frequency in adult participants with refractory or unexplained chronic cough.

Product Name : Lyfnua

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

August 09, 2020

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FDF Dossiers

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Merck & Co

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American Thoracic Society
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Merck & Co

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American Thoracic Society
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Gefapiksantsitrat

Brand Name : Lyfnua

Dosage Form : Tablet, film-coated

Dosage Strength : 45 mg

Packaging : Blisterpakning 56item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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ABOUT THIS PAGE

Looking for 1015787-98-0 / Gefapixant Citrate API manufacturers, exporters & distributors?

Gefapixant Citrate manufacturers, exporters & distributors 1

89

PharmaCompass offers a list of Gefapixant Citrate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Gefapixant Citrate manufacturer or Gefapixant Citrate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Gefapixant Citrate manufacturer or Gefapixant Citrate supplier.

PharmaCompass also assists you with knowing the Gefapixant Citrate API Price utilized in the formulation of products. Gefapixant Citrate API Price is not always fixed or binding as the Gefapixant Citrate Price is obtained through a variety of data sources. The Gefapixant Citrate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Gefapixant Citrate

Synonyms

1015787-98-0, Af-219, Mk-7264, Gefapixant [usan], Ro4926219, Rg-1646

Cas Number

1015787-98-0

Unique Ingredient Identifier (UNII)

6K6L7E3F1L

About Gefapixant Citrate

Gefapixant is under investigation in clinical trial NCT02397460 (Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity).

Gefapixant Citrate Manufacturers

A Gefapixant Citrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Gefapixant Citrate, including repackagers and relabelers. The FDA regulates Gefapixant Citrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Gefapixant Citrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Gefapixant Citrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Gefapixant Citrate Suppliers

A Gefapixant Citrate supplier is an individual or a company that provides Gefapixant Citrate active pharmaceutical ingredient (API) or Gefapixant Citrate finished formulations upon request. The Gefapixant Citrate suppliers may include Gefapixant Citrate API manufacturers, exporters, distributors and traders.

click here to find a list of Gefapixant Citrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Gefapixant Citrate GMP

Gefapixant Citrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Gefapixant Citrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Gefapixant Citrate GMP manufacturer or Gefapixant Citrate GMP API supplier for your needs.

Gefapixant Citrate CoA

A Gefapixant Citrate CoA (Certificate of Analysis) is a formal document that attests to Gefapixant Citrate's compliance with Gefapixant Citrate specifications and serves as a tool for batch-level quality control.

Gefapixant Citrate CoA mostly includes findings from lab analyses of a specific batch. For each Gefapixant Citrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Gefapixant Citrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Gefapixant Citrate EP), Gefapixant Citrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Gefapixant Citrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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