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Gallium Citrate GA-67

Gallium Citrate GA-67

Synopsis, Chemistry

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Also known as: Gallium citrate ga 67, Gallium-67 citrate, Gallium (67 ga) citrate, 41183-64-6, Gallium (67ga) citrate, Gallium-(sup 67)ga citrate (1:1)

Molecular Formula

C₆H₅GaO₇

Molecular Weight

256.03 g/mol

InChI Key

YEEGWNXDUZONAA-RYDPDVNUSA-K

FDA UNII

4LJK511Z86

Gallium Citrate Ga-67 is the citrate salt of the radioisotope gallium Ga 67. Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation, allowing scintigraphic localization. Ga-67 scintigraphy (GS) cannot differentiate between tumor and acute inflammation.

Gallium citrate ga-67 is a Radioactive Diagnostic Agent. The mechanism of action of gallium citrate ga-67 is as a Radiopharmaceutical Activity.

1 2D Structure

Gallium Citrate GA-67

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

gallium-67(3+);2-hydroxypropane-1,2,3-tricarboxylate

2.1.2 InChI

InChI=1S/C6H8O7.Ga/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3/i;1-3

2.1.3 InChI Key

YEEGWNXDUZONAA-RYDPDVNUSA-K

2.1.4 Canonical SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Ga+3]

2.1.5 Isomeric SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[67Ga+3]

2.2 Other Identifiers

2.2.1 UNII

4LJK511Z86

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 67ga Radioisotope

2. Ga-67 Radioisotope

3. Gallium-67

2.3.2 Depositor-Supplied Synonyms

1. Gallium Citrate Ga 67

2. Gallium-67 Citrate

3. Gallium (67 Ga) Citrate

4. 41183-64-6

5. Gallium (67ga) Citrate

6. Gallium-(sup 67)ga Citrate (1:1)

7. Neoscan

8. Gallium ((sup 67)ga) Citrate

9. Gallium (67ga) Citrate [inn]

10. 4ljk511z86

11. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Gallium-(sup 67)ga (1:1) Salt

12. Gallium (67ga) Citrate (inn)

13. (67-ga)gallium Citrate

14. Gallium Citrate (ga67)

15. Einecs 255-248-4

16. Gallii (67 Ga) Citras

17. Gallii (67 Ga) Citras [inn-latin]

18. Citrato De Galio (67 Ga)

19. Citrate De Gallium (67 Ga)

20. Unii-4ljk511z86

21. Citrato De Galio (67 Ga) [inn-spanish]

22. Citrate De Gallium (67 Ga) [inn-french]

23. Gallium Citrate, Ga-67

24. 67ga Radioisotope

25. Neoscan (tn)

26. Ga-67 Radioisotope

27. Gallium 67 Citrate

28. Gallium Citrate,ga-67

29. Gallium Ga-67 Citrate

30. Gallium Citrate Ga 67 [usan:usp:jan]

31. Gallium Citrate (67 Ga)

32. Schembl9754280

33. Gallium Citrate Ga 67 (usp)

34. Gallium-67ga Citrate (1:1)

35. Gallium-67(3+); 2-hydroxypropane-1,2,3-tricarboxylate

36. Chebi:31645

37. Dtxsid70194107

38. Gallium Citrate Ga 67 [mi]

39. Db06784

40. Gallium Citrate Ga 67 [usan]

41. Gallium Citrate,ga-67 [vandf]

42. Gallium (67ga) Citrate [who-dd]

43. Gallium (67ga) Citrate Injection (jp17)

44. Gallium Citrate Ga-67 [orange Book]

45. Gallium Citrate Ga 67 [usp Impurity]

46. D01936

47. Q27260007

48. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Gallium-67ga (1:1) Salt

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₆H₅GaO₇
Molecular Weight	256.03 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	255.93173 g/mol
Monoisotopic Mass	255.93173 g/mol
Topological Polar Surface Area	141 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	211
Isotope Atom Count	1
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Gallium Citrate Ga 67 Injection may be useful to demonstrate the presence and extent of Hodgkin's disease, lymphoma, and bronchogenic carcinoma. Positive gallium Ga-67 uptake in the absence of prior symptoms warrants follow-up as an indication of a potential disease state. Gallium Citrate Ga 67 Injection may be useful as an aid in detecting some acute inflammatory lesions.

5 Pharmacology and Biochemistry

5.1 Pharmacology

It has been reported in the scientific literature that following intravenous injection, the highest tissue concentration of gallium Ga-67 - other than tumors and sites of infection - is the renal cortex. After the first day, the maximum concentration shifts to bone and lymph nodes and after the first week, to liver and spleen. Gallium Ga-67 is excreted relatively slowly from the body. The average whole body retention is 65 percent after seven days, with 26 percent having been excreted in the urine and 9 percent in the stools.

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

GALLIUM CITRATE GA-67

5.2.2 FDA UNII

4LJK511Z86

5.2.3 Pharmacological Classes

Mechanisms of Action [MoA] - Radiopharmaceutical Activity

5.3 ATC Code

V - Various

V09 - Diagnostic radiopharmaceuticals

V09H - Inflammation and infection detection

V09HX - Other diagnostic radiopharmaceuticals for inflammation and infection detection

V09HX01 - Gallium (67Ga) citrate

5.4 Absorption, Distribution and Excretion

Absorption

The body generally handles Ga3+ as though it were ferric iron (Fe-III). However, gallium can not be reduced in vivo. Therefore, ferric ion is easily reduced and interacts with protoporphyrin IX to form heme, gallium remains bound to iron-transport proteins and carrier molecules.

Route of Elimination

No urinary excretion; elimination primarily via fecal excretion.

5.5 Biological Half-Life

78.26 hours

5.6 Mechanism of Action

Gallium Citrate Ga 67, with no carrier added, has been found to concentrate in certain viable primary and metastatic tumors as well as focal sites of infection. The body generally handles Ga3+ as though it were ferric iron (Fe-III), and thus the free isotope ion is bound (and concentrates) in areas of inflammation, such as an infection site, and also areas of rapid cell division. Ga-67 binds to transferrin, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins, and cell-membranes in neutrophils, both living and dead. Lactoferrin is contained within leukocytes. Ga-67 may bind to lactoferrin and be transported to sites of inflammation, or binds to lactoferrin released during bacterial phagocytosis at infection sites (and remains due to binding with macrophage receptors). Ga-67 also attaches to the siderophore molecules of bacteria themselves, and for this reason can be used in leukopenic patients with bacterial infection (here it attaches directly to bacterial proteins, and leukocytes are not needed). Uptake is thought to be associated with a range of tumour properties including transferring receptors, anaerobic tumor metabolism and tumor perfusion and vascular permeability.