Find Fosphenytoin Sodium manufacturers, exporters & distributors on PharmaCompass

Fosphenytoin Sodium

Fosphenytoin Sodium

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

12 API Suppliers, 9 USDMF, 3 EU WC, 5 NDC API, 5 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Formulations

26 Dossiers, 17 FDA Orange Book, 2 Europe, 1 Canada, 6 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 1 Actylis, 1 DKSH, 1 BioSpectra

EXCIPIENTS BY APPLICATIONS

2 Parenteral, 1 Topical

GLOBAL SALES INFORMATION

15 US Medicaid Prescriptions, 1 Finished Drug Prices

MARKET PLACE

5 APIs, 1 DOSSIERS // FDF

PATENTS

10 US Patents

10 US Patents

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

3 News

3 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

2,542

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 92134-98-0, Fosphenytoin disodium salt, Cerebyx, Pro-epanutin, Ci 982, Ci-982

Molecular Formula

C₁₆H₁₃N₂Na₂O₆P

Molecular Weight

406.24 g/mol

InChI Key

GQPXYJNXTAFDLT-UHFFFAOYSA-L

FDA UNII

7VLR55452Z

Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Phenytoin exerts its effect most likely through an enhancement of sodium efflux from neurons in the motor cortex. This leads to a suppression of excessive neuronal firing and spread of seizure activity. Other physiologic effects from actions of phenytoin include modulation of the voltage-dependent calcium channels of neurons, inhibition of calcium flux across neuronal membranes and enhancement of sodium-potassium ATPase activity of neurons and glial cells. (NCI05)

1 2D Structure

Fosphenytoin Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate

2.1.2 InChI

InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2

2.1.3 InChI Key

GQPXYJNXTAFDLT-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)([O-])[O-])C3=CC=CC=C3.[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

7VLR55452Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3-(hydroxymethyl)phenytoin Disodium Phosphate

2. 3-(hydroxymethyl)phenytoin Phosphate Ester

3. Acc 9653

4. Acc-9653

5. Cerebyx

6. Fosphenytoin

7. Fosphenytoin, Disodium Salt

8. Hmpdp

9. Prodilantin

2.3.2 Depositor-Supplied Synonyms

1. 92134-98-0

2. Fosphenytoin Disodium Salt

3. Cerebyx

4. Pro-epanutin

5. Ci 982

6. Ci-982

7. Fosphenytoin (sodium)

8. Acc-9653

9. Acc-9653-010 (sodium Salt)

10. Disodium;(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl Phosphate

11. Fosphenytoin (disodium)

12. 3-(hydroxymethyl)-5,5-diphenylhydantoin, Disodium Phosphate (ester)

13. 7vlr55452z

14. 92134-98-0 (sodium)

15. Acc-9653-010

16. 2,4-imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, Disodium Salt

17. Fosphenytoin Disodium

18. Sodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl Phosphate

19. Fosphenytoinsodium

20. Acc 9653

21. Fosphenytoin Sodium [usan]

22. Fosphenytoin_sodium

23. Fosphenytoin Disodium Salt Hydrate

24. Acc 9653-010

25. Fostoin

26. Unii-7vlr55452z

27. Fosphenytoin Sodium [usan:usp]

28. Phosphenytoin Sodium

29. Cerebyx (tn)

30. Fosphenytoin Sodium Salt

31. Chembl919

32. Fosphenytoin Sodium (usp)

33. Schembl119417

34. Npc-06

35. Dtxsid1044271

36. Fosphenytoin Sodium [vandf]

37. Bcp13859

38. Fosphenytoin Sodium [mart.]

39. Disodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl Phosphate

40. Fosphenytoin Sodium [usp-rs]

41. Fosphenytoin Sodium [who-dd]

42. 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione Disodium Salt

43. Akos015915510

44. Ac-1705

45. Fosphenytoin Disodium Salt [mi]

46. Fosphenytoin Sodium [orange Book]

47. Fosphenytoin Sodium [usp Impurity]

48. Fosphenytoin Sodium [usp Monograph]

49. Db-057291

50. Ft-0630980

51. D02096

52. D81920

53. A844152

54. Acc 9653 Pound>>acc9653 Pound>>acc-9653

55. Q27268914

56. Disodium (2,5-dioxo-4,4-diphenyl-1-imidazolidinyl)methyl Phosphate

57. Disodium [2,5-bis(oxidanylidene)-4,4-diphenyl-imidazolidin-1-yl]methyl Phosphate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₃N₂Na₂O₆P
Molecular Weight	406.24 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	406.03066170 g/mol
Monoisotopic Mass	406.03066170 g/mol
Topological Polar Surface Area	122 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	536
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Cerebyx
PubMed Health	fosphenytoin
Drug Classes	Anticonvulsant
Drug Label	CEREBYX (fosphenytoin sodium injection) is a prodrug intended for parenteral administration; its active metabolite is phenytoin. 1.5 mg of fosphenytoin sodium is equivalent to 1 mg phenytoin sodium, and is referred to as 1 mg phenytoin sodium equiv...
Active Ingredient	Fosphenytoin sodium
Dosage Form	Injectable

2 of 4
Drug Name	Fosphenytoin sodium
PubMed Health	fosphenytoin
Drug Label	Fosphenytoin Sodium Injection, USP is a prodrug intended for parenteral administration; its active metabolite is phenytoin.1.5 mg of fosphenytoin sodium is equivalent to 1 mg phenytoin sodium, and is referred to as 1 mg phenytoin sodium equivalents...
Active Ingredient	Fosphenytoin sodium
Dosage Form	Injectable

3 of 4
Drug Name	Cerebyx
PubMed Health	fosphenytoin
Drug Classes	Anticonvulsant
Drug Label	CEREBYX (fosphenytoin sodium injection) is a prodrug intended for parenteral administration; its active metabolite is phenytoin. 1.5 mg of fosphenytoin sodium is equivalent to 1 mg phenytoin sodium, and is referred to as 1 mg phenytoin sodium equiv...
Active Ingredient	Fosphenytoin sodium
Dosage Form	Injectable

4 of 4
Drug Name	Fosphenytoin sodium
PubMed Health	fosphenytoin
Drug Label	Fosphenytoin Sodium Injection, USP is a prodrug intended for parenteral administration; its active metabolite is phenytoin.1.5 mg of fosphenytoin sodium is equivalent to 1 mg phenytoin sodium, and is referred to as 1 mg phenytoin sodium equivalents...
Active Ingredient	Fosphenytoin sodium
Dosage Form	Injectable

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Sodium Channel Blockers

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. (See all compounds classified as Sodium Channel Blockers.)

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cytochrome P450 1A2 Inducers [MoA]; Cytochrome P450 2B6 Inducers [MoA]; Cytochrome P450 2C19 Inducers [MoA]; Cytochrome P450 2C8 Inducers [MoA]; Cytochrome P450 2C9 Inducers [MoA]; Cytochrome P450 2D6 Inducers [MoA]; Cytochrome P450 3A Inducers [MoA]; Decreased Central Nervous System Disorganized Electrical Activity [PE]; Anti-epileptic Agent [EPC]