Fosaprepitant

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

34 API Suppliers, 16 USDMF, 3 JDMF, 6 EU WC, 3 KDMF, 12 NDC API, 23 Listed Suppliers

DEVELOPMENTS

3 Drug(s) in Development

3 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

3 Suppliers

3 Suppliers

DOSSIERs // Finished Dosage Formulations

44 Dossiers, 24 FDA Orange Book, 4 Europe, 1 Canada, 6 Australia, 1 South Africa, 8 Listed Dossiers

DRUG PRODUCT COMPOSITION

POWDER;INTRAVENOUS - EQ 115MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, POWDER;INTRAVENOUS - EQ 150MG BASE/VIAL

POWDER;INTRAVENOUS - EQ 115MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
POWDER;INTRAVENOUS - EQ 150MG BASE/VIAL

RELATED EXCIPIENT COMPANIES

Suppliers, 7 Kerry, 6 Seppic, 3 Actylis, 3 Gangwal Chemicals, 2 Nanjing Well Pharmaceutical, 1 BASF, 1 DFE Pharma, 1 Jai Radhe Sales, 1 Microlex e.U, 1 Nanjing Bold Chemical

EXCIPIENTS BY APPLICATIONS

10 Solubilizers, 7 Parenteral, 5 Fillers, Diluents & Binders, 3 Emulsifying Agents, 3 Topical, 3 Co-Processed Excipients, 3 Direct Compression, 2 Surfactant & Foaming Agents, 1 API Stability Enhancers, 1 Thickeners and Stabilizers, 1 Film Formers & Plasticizers, 1 Granulation, 1 Rheology Modifiers

GLOBAL SALES INFORMATION

33 US Medicaid Prescriptions, 2 Finished Drug Prices

MARKET PLACE

1 DOSSIERS // FDF

1 DOSSIERS // FDF

PATENTS

1 US Patents, 2 US Exclusivities, 2 Health Canada Patents

DIGITAL CONTENT

30 News

30 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

20,627

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

51.00

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as:

Molecular Formula

C₃₇H₅₆F₇N₆O₁₆P

Molecular Weight

1004.8 g/mol

InChI Key

VRQHBYGYXDWZDL-OOZCZQCLSA-N

1 2D Structure

Fosaprepitant

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-3-oxo-1H-1,2,4-triazol-2-yl]phosphonic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

2.1.2 InChI

InChI=1S/C23H22F7N4O6P.2C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);2*4-13H,2-3H2,1H3/t12-,19+,20-;2*4-,5+,6+,7+/m100/s1

2.1.3 InChI Key

VRQHBYGYXDWZDL-OOZCZQCLSA-N

2.1.4 Canonical SMILES

CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNCC(C(C(C(CO)O)O)O)O.CNCC(C(C(C(CO)O)O)O)O

2.1.5 Isomeric SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

2.2 Create Date

2007-02-10

3 Chemical and Physical Properties

Molecular Formula	C₃₇H₅₆F₇N₆O₁₆P
Molecular Weight	1004.8 g/mol
Hydrogen Bond Donor Count	15
Hydrogen Bond Acceptor Count	26
Rotatable Bond Count	19
Exact Mass	1004.33786385 g/mol
Monoisotopic Mass	1004.33786385 g/mol
Topological Polar Surface Area	350 A^2
Heavy Atom Count	67
Formal Charge	0
Complexity	1130
Isotope Atom Count	0
Defined Atom Stereocenter Count	11
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

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Fosaprepitant

Fosaprepitant

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

34 API Suppliers

16 USDMF

3 JDMF

6 EU WC

3 KDMF

12 NDC API

23 Listed Suppliers

DEVELOPMENTS

3 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Exports

FDF Imports

INTERMEDIATES

3 Suppliers

DOSSIERs // Finished Dosage Formulations

44 Dossiers

24 FDA Orange Book

4 Europe

1 Canada

6 Australia

1 South Africa

8 Listed Dossiers

DRUG PRODUCT COMPOSITION

POWDER;INTRAVENOUS - EQ 115MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

POWDER;INTRAVENOUS - EQ 150MG BASE/VIAL

RELATED EXCIPIENT COMPANIES

Suppliers

7 Kerry

6 Seppic

3 Actylis

3 Gangwal Chemicals

2 Nanjing Well Pharmaceutical

1 BASF

1 DFE Pharma

1 Jai Radhe Sales

1 Microlex e.U

1 Nanjing Bold Chemical

EXCIPIENTS BY APPLICATIONS

10 Solubilizers

7 Parenteral

5 Fillers, Diluents & Binders

3 Emulsifying Agents

3 Topical

3 Co-Processed Excipients

3 Direct Compression

2 Surfactant & Foaming Agents

1 API Stability Enhancers

1 Thickeners and Stabilizers

1 Film Formers & Plasticizers

1 Granulation

1 Rheology Modifiers

GLOBAL SALES INFORMATION

33 US Medicaid Prescriptions

2 Finished Drug Prices

MARKET PLACE

1 DOSSIERS // FDF

PATENTS

1 US Patents

2 US Exclusivities

2 Health Canada Patents

DIGITAL CONTENT

30 News

API SUPPLIERS

API REF. PRICE (USD / KG)

INTERMEDIATES

DOSSIERS // FDF

GLOBAL SALES (USD Million)

EXCIPIENTS

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

REF STANDARD

POWDER;INTRAVENOUS - EQ 115MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons