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Chemistry

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Also known as:
Molecular Formula
C19H19N7O6
Molecular Weight
441.4  g/mol
InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N

Folic Acid
1 2D Structure

Folic Acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
2.1.2 InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
2.1.3 InChI Key
OVBPIULPVIDEAO-LBPRGKRZSA-N
2.1.4 Canonical SMILES
C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
2.1.5 Isomeric SMILES
C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N
2.2 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 441.4 g/mol
Molecular Formula C19H19N7O6
XLogP3-1.1
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass441.13968135 g/mol
Monoisotopic Mass441.13968135 g/mol
Topological Polar Surface Area209 Ų
Heavy Atom Count32
Formal Charge0
Complexity767
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameFolic acid
PubMed HealthFolic Acid
Drug ClassesNutriceutical, Nutritive Agent
Drug LabelFolic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
Active IngredientFolic acid
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength1 mg; 1mg; 5mg/ml
Market StatusPrescription
CompanyBicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

2 of 2  
Drug NameFolic acid
PubMed HealthFolic Acid
Drug ClassesNutriceutical, Nutritive Agent
Drug LabelFolic acid, N-[p-[[(2-amino-4-hydroxy-6-pteridiny)methyl]amino]benzoyl]-L-glutamic acid, is a B complex vitamin containing a pteridine moiety linked by a methylene bridge to para-aminobenzoic acid, which is joined by a peptide linkage to glutamic aci...
Active IngredientFolic acid
Dosage FormTablet; Injectable
RouteInjection; Oral
Strength1 mg; 1mg; 5mg/ml
Market StatusPrescription
CompanyBicon Pharm; Excellium; Jubilant Cadista; Cadila Pharms; Invagen Pharms; Hikma Pharms; Watson Labs; Amneal Pharm; Fresenius Kabi Usa; Vintage; Contract Pharmacal

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NUTRACEUTICALS","customerCountry":"INDIA","quantity":"2250.00","actualQuantity":"2250","unit":"KGS","unitRateFc":"22.5","totalValueFC":"51188.9","currency":"USD","unitRateINR":"1899.8","date":"24-Apr-2024","totalValueINR":"4274649","totalValueInUsd":"51188.9","indian_port":"Madras Sea","hs_no":"29362910","bill_no":"3187425","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM,919,BUILDING 1,NO,399,SHENGXIA ROAD,A-SUN HI-TECH PARKSHANGHAI CN","customerAddress":"211\/1A 211\/1C 212\/3,RUPENAGUNTLA V"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720204200,"product":"VITAMIN MIX PDR;013114\/002","address":"PLOT NO.26,2ND CROSS,JIGANI","city":"BANGALORE","supplier":"GIVAUDAN INTERNTIONAL AG","supplierCountry":"NETHERLANDS","foreign_port":"JOHANNESBURG - JOHAN","customer":"GIVAUDAN (INDIA) PRIVATE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"36.6","totalValueFC":"1846.9","currency":"USD","unitRateINR":"3087.6","date":"06-Jul-2024","totalValueINR":"154382.38","totalValueInUsd":"1846.9","indian_port":"Bombay Air","hs_no":"29369000","bill_no":"4371189","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Pharma Grade","supplierPort":"JOHANNESBURG - JOHAN","supplierAddress":"NEUGUTSTRASSE 46 CH-8600 DUBENFORFSWITZERLAND, , SWITZERLANDSDNF SWITZERLAND","customerAddress":"PLOT NO.26,2ND CROSS,JIGANI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725993000,"product":"FOLIC ACID","address":"BLOCK - A, 6\/A","city":"AHMEDABAD","supplier":"KHONSU INTERNATIONAL CO LIMITED","supplierCountry":"CHINA","foreign_port":"SHANGHAI PT","customer":"ARCK LIFE CARE PRIVATE LIMITED","customerCountry":"INDIA","quantity":"2500.00","actualQuantity":"2500","unit":"KGS","unitRateFc":"22","totalValueFC":"55769","currency":"USD","unitRateINR":"1869.4","date":"11-Sep-2024","totalValueINR":"4673506.4","totalValueInUsd":"55769","indian_port":"JNPT","hs_no":"29362910","bill_no":"5554847","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI PT","supplierAddress":"CORPORATE SERVICES CENTRE SUITE 23 1ST FLLOR EDEN PLAZA EDEN ISLAND MAHE REPUBLIC OF SEYCHELLES FRENCH GUIANA","customerAddress":"BLOCK - A, 6\/A"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736101800,"product":"FOLIC ACID (NOT FOR MEDICINAL USE) FOLIC ACID (NOT FOR MEDICINAL USE)","address":"ROOM NO.34\/B, MANGALDAS BLDG NO.1","city":"MARINE LINES, MUMBAI, M.S.","supplier":"CIDIC HOLDING CO LIMITED","supplierCountry":"CAMBODIA","foreign_port":"LAEM CHABANG","customer":"MINERVA BIOGENIX PRIVATE LIMITED","customerCountry":"INDIA","quantity":"4500.00","actualQuantity":"4500","unit":"KGS","unitRateFc":"25.5","totalValueFC":"115243.4","currency":"USD","unitRateINR":"2208.3","date":"06-Jan-2025","totalValueINR":"9937350","totalValueInUsd":"115243.4","indian_port":"JNPT","hs_no":"29362910","bill_no":"7643376","productDescription":"API","marketType":"","country":"CAMBODIA","selfForZScoreResived":"Pharma Grade","supplierPort":"LAEM CHABANG","supplierAddress":"RM-1002,10\/F,EASEY COMM BLDG 253-261 HENNESSY ROAD WANCHAI HONGKONG HK","customerAddress":"ROOM NO.34\/B, MANGALDAS BLDG NO.1"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740421800,"product":"FOLIC ACID(NOT FOR MEDICINAL USE) FOLIC ACID(NOT FOR MEDICINAL USE)","address":"ROOM NO.34\/B, MANGALDAS BLDG NO.1","city":"MARINE LINES, MUMBAI, M.S.","supplier":"CIDIC HOLDING CO LIMITED","supplierCountry":"CHINA","foreign_port":"BANGKOK","customer":"MINERVA BIOGENIX PRIVATE LIMITED","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"34.3","totalValueFC":"34578.6","currency":"USD","unitRateINR":"3007.1","date":"25-Feb-2025","totalValueINR":"3007100","totalValueInUsd":"34578.6","indian_port":"JNPT","hs_no":"29362910","bill_no":"8562098","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGKOK","supplierAddress":"RM 1002,10\/F ,EASEY COMM BLDG 253- 261,HENNESSY ROAD, WANCHAI HONG KON G China","customerAddress":"ROOM NO.34\/B, MANGALDAS BLDG NO.1"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741199400,"product":"FOLIC ACID IP\/USP","address":"303, KALASAGAR SHOPPING HUB,,SATAD","city":"AHMEDABAD,GUJARAT","supplier":"MCCOY DRUGS PVT LTD","supplierCountry":"INDIA","foreign_port":"SURAT(EPZ\/SEZ)","customer":"TRENTIUM LIFESCIENCES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"750.00","actualQuantity":"750","unit":"KGS","unitRateFc":"39.1","totalValueFC":"29699.5","currency":"USD","unitRateINR":"3430","date":"06-Mar-2025","totalValueINR":"2572500","totalValueInUsd":"29699.5","indian_port":"Surat-EPZ\/SEZ","hs_no":"29362910","bill_no":"8729389","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"SURAT(EPZ\/SEZ)","supplierAddress":"Plot No.146B\/147, SURSEZ Diamond Park, Road No.3, Sachin GIDC, Surat SDNF India","customerAddress":"303, KALASAGAR SHOPPING HUB,,SATAD"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1741804200,"product":"FOLIC ACID (NOT FOR MEDICINAL USE) BATCH NO.:250222001 NA","address":"25D, Basant Vihar,","city":"Agra","supplier":"AMS CHINA(HK)COLIMITED COMPANY","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"RADHASHOK PHARMACHEM PRIVATE LIMITED","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"37","totalValueFC":"18752.5","currency":"USD","unitRateINR":"3248.6","date":"13-Mar-2025","totalValueINR":"1624300","totalValueInUsd":"18752.5","indian_port":"Delhi Air","hs_no":"29309099","bill_no":"8867730","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"UNIT 1406A,14\/F,THE BELGIAN BANK BUILDING,NOS.721 -725 NATHAN ROAD KOWLOON,HONGKONG CHINA","customerAddress":"25D, Basant Vihar,"}]
04-Feb-2022
07-Apr-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL...DOSAGE - FOR SOLUTION;INTRAVENOUS - 80MG/VIAL;0.02MG/VIAL;0.001MG/VIAL;5MG/VIAL;0.01MG/VIAL;0.14MG/VIAL;17MG/VIAL;0.2MG/VIAL;1MG/VIAL;1.4MG/VIAL;EQ 1.2MG BASE/VIAL;0.7MG/VIAL;7MG/VIAL

USFDA APPLICATION NUMBER - 18920

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DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;0.03MG/ML

USFDA APPLICATION NUMBER - 21163

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DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/...DOSAGE - SOLUTION;INTRAVENOUS - 2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML

USFDA APPLICATION NUMBER - 21163

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DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;...DOSAGE - INJECTABLE;INTRAVENOUS - 200MG/VIAL;0.06MG/VIAL;0.005MG/VIAL;15MG/VIAL;0.005MG/VIAL;0.6MG/VIAL;40MG/VIAL;6MG/VIAL;3.6MG/VIAL;6MG/VIAL;1MG/VIAL;10MG/VIAL;0.15MG/VIAL

USFDA APPLICATION NUMBER - 21625

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DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006...DOSAGE - INJECTABLE;INJECTION - 20MG/ML;0.006MG/ML;0.05MCG/ML;1.5MG/ML;0.0005MG/ML;0.06MG/ML;4MG/ML;0.6MG/ML;0.36MG/ML;0.6MG/ML;0.1MG/ML;1MG/ML

USFDA APPLICATION NUMBER - 8809

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ABOUT THIS PAGE

Looking for / Folic Acid API manufacturers, exporters & distributors?

Folic Acid manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Folic Acid API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Folic Acid manufacturer or Folic Acid supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Folic Acid manufacturer or Folic Acid supplier.

PharmaCompass also assists you with knowing the Folic Acid API Price utilized in the formulation of products. Folic Acid API Price is not always fixed or binding as the Folic Acid Price is obtained through a variety of data sources. The Folic Acid Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Folic Acid

Folacid Manufacturers

A Folacid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Folacid, including repackagers and relabelers. The FDA regulates Folacid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Folacid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Folacid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Folacid Suppliers

A Folacid supplier is an individual or a company that provides Folacid active pharmaceutical ingredient (API) or Folacid finished formulations upon request. The Folacid suppliers may include Folacid API manufacturers, exporters, distributors and traders.

click here to find a list of Folacid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Folacid USDMF

A Folacid DMF (Drug Master File) is a document detailing the whole manufacturing process of Folacid active pharmaceutical ingredient (API) in detail. Different forms of Folacid DMFs exist exist since differing nations have different regulations, such as Folacid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Folacid DMF submitted to regulatory agencies in the US is known as a USDMF. Folacid USDMF includes data on Folacid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Folacid USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Folacid suppliers with USDMF on PharmaCompass.

Folacid JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Folacid Drug Master File in Japan (Folacid JDMF) empowers Folacid API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Folacid JDMF during the approval evaluation for pharmaceutical products. At the time of Folacid JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Folacid suppliers with JDMF on PharmaCompass.

Folacid CEP

A Folacid CEP of the European Pharmacopoeia monograph is often referred to as a Folacid Certificate of Suitability (COS). The purpose of a Folacid CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Folacid EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Folacid to their clients by showing that a Folacid CEP has been issued for it. The manufacturer submits a Folacid CEP (COS) as part of the market authorization procedure, and it takes on the role of a Folacid CEP holder for the record. Additionally, the data presented in the Folacid CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Folacid DMF.

A Folacid CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Folacid CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Folacid suppliers with CEP (COS) on PharmaCompass.

Folacid WC

A Folacid written confirmation (Folacid WC) is an official document issued by a regulatory agency to a Folacid manufacturer, verifying that the manufacturing facility of a Folacid active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Folacid APIs or Folacid finished pharmaceutical products to another nation, regulatory agencies frequently require a Folacid WC (written confirmation) as part of the regulatory process.

click here to find a list of Folacid suppliers with Written Confirmation (WC) on PharmaCompass.

Folacid NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Folacid as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Folacid API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Folacid as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Folacid and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Folacid NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Folacid suppliers with NDC on PharmaCompass.

Folacid GMP

Folacid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Folacid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Folacid GMP manufacturer or Folacid GMP API supplier for your needs.

Folacid CoA

A Folacid CoA (Certificate of Analysis) is a formal document that attests to Folacid's compliance with Folacid specifications and serves as a tool for batch-level quality control.

Folacid CoA mostly includes findings from lab analyses of a specific batch. For each Folacid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Folacid may be tested according to a variety of international standards, such as European Pharmacopoeia (Folacid EP), Folacid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Folacid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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