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Flurazepam Monohydrochloride

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Also known as: 36105-20-1, Dalmate, 7c4jh842ij, Dalmadorm, Dalmane, Felison

Molecular Formula

C₂₁H₂₄Cl₂FN₃O

Molecular Weight

424.3 g/mol

InChI Key

PUGVROXLRUQCAF-UHFFFAOYSA-N

FDA UNII

7C4JH842IJ

A benzodiazepine derivative used mainly as a hypnotic.

1 2D Structure

Flurazepam Monohydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;hydrochloride

2.1.2 InChI

InChI=1S/C21H23ClFN3O.ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;/h5-10,13H,3-4,11-12,14H2,1-2H3;1H

2.1.3 InChI Key

PUGVROXLRUQCAF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl

2.2 Other Identifiers

2.2.1 UNII

7C4JH842IJ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Apo Flurazepam

2. Apo-flurazepam

3. Dalmadorm

4. Dalmane

5. Dihydrochloride, Flurazepam

6. Dormodor

7. Flurazepam

8. Flurazepam Dihydrochloride

9. Flurazepam Hydrochloride

10. Flurazepam Mono Perchlorate

11. Flurazepam Mono-perchlorate

12. Hydrochloride, Flurazepam

13. Mono-perchlorate, Flurazepam

14. Monohydrochloride, Flurazepam

15. Staurodorm

2.3.2 Depositor-Supplied Synonyms

1. 36105-20-1

2. Dalmate

3. 7c4jh842ij

4. Dalmadorm

5. Dalmane

6. Felison

7. Linzac

8. Natam

9. Insumin Dihydrochloride

10. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;hydrochloride

11. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Monohydrochloride

12. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride

13. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride

14. Id 480

15. Einecs 252-867-1

16. Unii-7c4jh842ij

17. Fluzepam

18. Dalmate (tn)

19. Fluorazepam Hydrochloride

20. Schembl29794

21. Chebi:31626

22. Flurazepam Hydrochloride (jp17)

23. Dtxsid40189686

24. Nsc78559

25. Flurazepam Monohydrochloride [mart.]

26. D01408

27. Flurazepam Monohydrochloride [ep Monograph]

28. Q27268050

29. Wln: T67 Gnv Jn Ihj Cg G2n2&2 Kr Bf &gh 2

30. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

31. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-, Dihydrochloride

32. 2h-1, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-,1,3-dihydro-, Dihydrochloride

33. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Hydrochloride (1:1)

34. 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,4-benzodiazepin-2-one Dihydrochloride

35. Flurazepam Monohydrochloride; 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2h-benzo-1,4-diazepin-2-one Monohydrochloride; 2h-1,4-benzodiazepin-2-one, 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-,1,3-dihydro-, Dihydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₄Cl₂FN₃O
Molecular Weight	424.3 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	423.1280459 g/mol
Monoisotopic Mass	423.1280459 g/mol
Topological Polar Surface Area	35.9 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	540
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Flurazepam hydrochloride
Drug Label	Flurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active Ingredient	Flurazepam hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	30mg; 15mg
Market Status	Prescription
Company	Mylan Pharms

2 of 2
Drug Name	Flurazepam hydrochloride
Drug Label	Flurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active Ingredient	Flurazepam hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	30mg; 15mg
Market Status	Prescription
Company	Mylan Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)