Find Fludarabine Phosphate manufacturers, exporters & distributors on PharmaCompass

Fludarabine

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

32 API Suppliers, 14 USDMF, 7 CEP/COS, 4 NDC API, 20 Listed Suppliers

DEVELOPMENTS

184 Drug(s) in Development

184 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports

DOSSIERs // Finished Dosage Formulations

64 Dossiers, 13 FDA Orange Book, 31 Europe, 3 Canada, 5 Australia, 3 South Africa, 9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 12 SPI Pharma, 3 Roquette, 2 Gangwal Chemicals, 2 Kerry, 2 Microlex e.U, 2 Gangwal Healthcare, 1 Pfanstiehl, 1 BASF, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Rochem International Inc, 1 Sigachi Industries, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Ingredion Pharma Solutions, 1 DKSH

EXCIPIENTS BY APPLICATIONS

18 Fillers, Diluents & Binders, 10 Direct Compression, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 4 Co-Processed Excipients, 3 Disintegrants & Superdisintegrants, 3 Parenteral, 3 Granulation, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

GLOBAL SALES INFORMATION

7 US Medicaid Prescriptions, 21 Finished Drug Prices

MARKET PLACE

1 APIs, 3 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

2 EDQM Standards, 1 USP Standards, 2 Other Ref. Standards

DIGITAL CONTENT

2 Data Compilations & Company Tracker #PharmaFlow, 16 News

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

199,247

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 75607-67-9, Fludara, Fludarabine 5'-monophosphate, Oforta, Fludarabine monophosphate, 2-fluoro-ara amp

Molecular Formula

C₁₀H₁₃FN₅O₇P

Molecular Weight

365.21 g/mol

InChI Key

GIUYCYHIANZCFB-FJFJXFQQSA-N

FDA UNII

1X9VK9O1SC

1 2D Structure

Fludarabine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

2.1.2 InChI

InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1

2.1.3 InChI Key

GIUYCYHIANZCFB-FJFJXFQQSA-N

2.1.4 Canonical SMILES

C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N

2.1.5 Isomeric SMILES

C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)F)N

2.2 Other Identifiers

2.2.1 UNII

1X9VK9O1SC

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 9 Beta-d-arabinofuranosyl-2-fluoroadenine Monophosphate

2. 9h-purin-6-amine, 2-fluoro-9-(5-o-phosphono-beta-d-arabinofuranosyl)-

3. Beneflur

4. F-ara-amp

5. Faraamp

6. Fludara

7. Fludarabine 5'-monophosphate

8. Fludarabine Monophosphate

9. Fluoro-ara-amp

10. Nsc 312887

11. Nsc-312887

2.3.2 Depositor-Supplied Synonyms

1. 75607-67-9

2. Fludara

3. Fludarabine 5'-monophosphate

4. Oforta

5. Fludarabine Monophosphate

6. 2-fluoro-ara Amp

7. 2-f-ara-amp

8. Fludarabine (phosphate)

9. Famp

10. Nsc-312887

11. 2-fluoro-9-(5-o-phosphono-beta-d-arabinofuranosyl)-9h-purin-6-amine

12. ((2r,3s,4s,5r)-5-(6-amino-2-fluoro-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl Dihydrogen Phosphate

13. Chebi:63599

14. 2-fluoroadenine Arabinoside 5'-monophosphate

15. 1x9vk9o1sc

16. 9-beta-arabinofuranosyl-2-fluoroadenine-5'-phosphate

17. 9-beta-d-arabinofuranosyl-2-fluoroadenine 5'-monophosphate

18. 75607-67-9 (phosphate)

19. 9-beta-d-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen Phosphate)

20. Fludarabine Phosphate (fludara)

21. {[(2r,3s,4s,5r)-5-(6-amino-2-fluoro-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic Acid

22. Nsc 312887

23. Nsc 328002

24. [(2r,3s,4s,5r)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl Dihydrogen Phosphate

25. Nsc-328002

26. Smr002544683

27. F-ara-amp

28. Sr-05000001945

29. Unii-1x9vk9o1sc

30. Beneflur

31. Fludara Phosphate

32. Fludara (tn)

33. Fludarabine-phosphate

34. 2-fluoro-ara-amp

35. Mfcd00866418

36. Fludarabine Phosphate [usan:usp:ban]

37. Fludarabine Phosphate;

38. 2f-ara-amp

39. Schembl3511

40. Nsc 312887 Phosphate

41. Mls003915617

42. Mls004774150

43. 9-bata-d-arabinofuranosyl-2-fluoroadenine Phosphate

44. Fludarabine Phosphate(fludara)

45. 9-.beta.-d-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen Phosphate)

46. Chembl1096882

47. Dtxsid2023060

48. Fludarabine Phosphate (jan/usp)

49. Sht-586

50. Fludarabine For System Suitability

51. Hms2094o11

52. Pharmakon1600-01505705

53. Fludarabine Phosphate [jan]

54. Ex-a2028

55. Hy-b0028

56. Nsc-118218h

57. Zinc3927870

58. Fludarabine Phosphate [usan]

59. Bdbm50248004

60. Fludarabine Phosphate [vandf]

61. Hg1010

62. Nsc759194

63. S1229

64. Fludarabine Phosphate [mart.]

65. 9h-purin-6-amine, 2-fluoro-9-(5-o-phosphono-beta-d-arabinofuranosyl)-

66. Akos024464516

67. Fludarabine Phosphate [usp-rs]

68. Fludarabine Phosphate [who-dd]

69. Bcp9000694

70. Ccg-213521

71. Cs-0861

72. F-ara-a (nsc 312887) Phosphate

73. Nsc-759194

74. Sri-5907-04

75. Sri-5907_05

76. Sri-5907_07

77. As-14202

78. Bcp0726000268

79. Fludarabine 5'-monophosphate [mi]

80. Fludarabine Phosphate [orange Book]

81. Sbi-0206893.p001

82. Fludarabine Phosphate [ep Monograph]

83. Fludarabine Phosphate [usp Monograph]

84. Sw218146-2

85. D01907

86. 607f679

87. A838460

88. Q185916

89. Sr-05000001945-1

90. Sr-05000001945-4

91. Z2235802254

92. 9-beta-d-arabinofuranosyl-2-fluoroadenine-5'-monophosphate

93. 9h-purin-6-amine, 2-fluoro-9-(5-o-phosphono-b-d-arabinofuranosyl)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₃FN₅O₇P
Molecular Weight	365.21 g/mol
XLogP3	-3.1
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	4
Exact Mass	365.05366293 g/mol
Monoisotopic Mass	365.05366293 g/mol
Topological Polar Surface Area	186 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	514
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Fludarabine phosphate
Drug Label	Fludarabine Phosphate Injection contains fludarabine phosphate, a fluorinated nucleotide analog of the antiviral agent vidarabine, 9- D-arabinofuranosyladenine (ara-A) that is relatively resistant to deamination by adenosine deaminase. Each mL cont...
Active Ingredient	Fludarabine phosphate
Dosage Form	Injectable
Route	Injection
Strength	50mg/2ml (25mg/ml); 50mg/vial
Market Status	Prescription
Company	Hospira; Teva Pharms Usa; Sandoz; Actavis Elizabeth; Mustafa Nevzat Ilac; Fresenius Kabi Usa; Onco Therapies

2 of 2
Drug Name	Fludarabine phosphate
Drug Label	Fludarabine Phosphate Injection contains fludarabine phosphate, a fluorinated nucleotide analog of the antiviral agent vidarabine, 9- D-arabinofuranosyladenine (ara-A) that is relatively resistant to deamination by adenosine deaminase. Each mL cont...
Active Ingredient	Fludarabine phosphate
Dosage Form	Injectable
Route	Injection
Strength	50mg/2ml (25mg/ml); 50mg/vial
Market Status	Prescription
Company	Hospira; Teva Pharms Usa; Sandoz; Actavis Elizabeth; Mustafa Nevzat Ilac; Fresenius Kabi Usa; Onco Therapies

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antimetabolites, Antineoplastic

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)

Immunosuppressive Agents

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Nucleoside Metabolic Inhibitor [EPC]; Nucleic Acid Synthesis Inhibitors [MoA]