Find Fisogatinib manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Blu-554, 1707289-21-1, Blu554, N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2h-pyran-4-yl)acrylamide, Blu111362, Fisogatinib [inn]
Molecular Formula
C24H24Cl2N4O4
Molecular Weight
503.4  g/mol
InChI Key
MGZKYOAQVGSSGC-DLBZAZTESA-N
FDA UNII
5Q7R99CKV2

Fisogatinib
Fisogatinib is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon oral administration, fisogatinib specifically binds to and blocks the binding of the ligand FGF19 to FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase and is involved in tumor cell proliferation, differentiation, angiogenesis, and survival. FGF19 is overexpressed by certain tumor cell types.
1 2D Structure

Fisogatinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide
2.1.2 InChI
InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1
2.1.3 InChI Key
MGZKYOAQVGSSGC-DLBZAZTESA-N
2.1.4 Canonical SMILES
COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)NC4COCCC4NC(=O)C=C)Cl)OC
2.1.5 Isomeric SMILES
COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC
2.2 Other Identifiers
2.2.1 UNII
5Q7R99CKV2
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-propenamide, N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl)amino)tetrahydro-2h-pyran-4-yl)-

2. Blu-554

3. N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)oxan-4-yl)prop-2-enamide

4. N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2h-pyran-4-yl)acrylamide

2.3.2 Depositor-Supplied Synonyms

1. Blu-554

2. 1707289-21-1

3. Blu554

4. N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2h-pyran-4-yl)acrylamide

5. Blu111362

6. Fisogatinib [inn]

7. Fisogatinib [usan]

8. X439161

9. Blu-111362

10. 5q7r99ckv2

11. Blu 554

12. X-439161

13. 2-propenamide, N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl)amino)tetrahydro-2h-pyran-4-yl)-

14. N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)oxan-4-yl)prop-2-enamide

15. N-[(3s,4s)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide

16. Blu554(fisogatinib)

17. Fisogatinib (usan/inn)

18. Unii-5q7r99ckv2

19. Fisogatinib [who-dd]

20. Blu 554 [who-dd]

21. Chembl4514636

22. Schembl16668287

23. Gtpl10220

24. Ex-a841

25. Amy16699

26. Bdbm50575072

27. Cs3008

28. Mfcd30496704

29. Nsc795718

30. S8503

31. Who 10947

32. Akos030632994

33. Ccg-269714

34. Cs-5986

35. Nsc-795718

36. Ac-29871

37. As-55934

38. Bb160379

39. Hy-100492

40. D11737

41. Q29209801

42. N-[(3s,4s)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]tetrahydro-2h-pyran-4-yl]-2-propenamide

2.4 Create Date
2015-09-28
3 Chemical and Physical Properties
Molecular Weight 503.4 g/mol
Molecular Formula C24H24Cl2N4O4
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass502.1174606 g/mol
Monoisotopic Mass502.1174606 g/mol
Topological Polar Surface Area94.6 Ų
Heavy Atom Count34
Formal Charge0
Complexity688
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


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Looking for 1707289-21-1 / Fisogatinib API manufacturers, exporters & distributors?

Fisogatinib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Fisogatinib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fisogatinib manufacturer or Fisogatinib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fisogatinib manufacturer or Fisogatinib supplier.

PharmaCompass also assists you with knowing the Fisogatinib API Price utilized in the formulation of products. Fisogatinib API Price is not always fixed or binding as the Fisogatinib Price is obtained through a variety of data sources. The Fisogatinib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Fisogatinib

Synonyms

Blu-554, 1707289-21-1, Blu554, N-((3s,4s)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2h-pyran-4-yl)acrylamide, Blu111362, Fisogatinib [inn]

Cas Number

1707289-21-1

Unique Ingredient Identifier (UNII)

5Q7R99CKV2

About Fisogatinib

Fisogatinib is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon oral administration, fisogatinib specifically binds to and blocks the binding of the ligand FGF19 to FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase and is involved in tumor cell proliferation, differentiation, angiogenesis, and survival. FGF19 is overexpressed by certain tumor cell types.

Fisogatinib Manufacturers

A Fisogatinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fisogatinib, including repackagers and relabelers. The FDA regulates Fisogatinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fisogatinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Fisogatinib Suppliers

A Fisogatinib supplier is an individual or a company that provides Fisogatinib active pharmaceutical ingredient (API) or Fisogatinib finished formulations upon request. The Fisogatinib suppliers may include Fisogatinib API manufacturers, exporters, distributors and traders.

Fisogatinib GMP

Fisogatinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fisogatinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fisogatinib GMP manufacturer or Fisogatinib GMP API supplier for your needs.

Fisogatinib CoA

A Fisogatinib CoA (Certificate of Analysis) is a formal document that attests to Fisogatinib's compliance with Fisogatinib specifications and serves as a tool for batch-level quality control.

Fisogatinib CoA mostly includes findings from lab analyses of a specific batch. For each Fisogatinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fisogatinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Fisogatinib EP), Fisogatinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fisogatinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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