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1. 23062-06-8
2. Fasedienol
3. Aloradine
4. 4,16-androstadien-3-beta-ol
5. 4,16-androstadien-3beta-ol
6. Dtw1nj7ijh
7. (3s,8s,9s,10r,13r,14s)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol
8. Androsta-4,16-dien-3-ol, (3b)-
9. (3s,8s,9s,10r,13r,14s)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1h-cyclopenta[a]phenanthren-3-ol
10. (3as,3bs,7s,9ar,9bs,11ar)-9a,11a-dimethyl-3h,3ah,3bh,4h,5h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-7-ol
11. 4-androstadienol
12. Unii-dtw1nj7ijh
13. Fasedienol [inn]
14. Aloradine [who-dd]
15. Ph94b
16. Androsta-4,16-dien-3beta-ol
17. Schembl4075431
18. Androsta-4,16-diene-3beta-ol
19. Dtxsid901032322
20. (3b)-androsta-4,16-dien-3-ol
21. Yaa06206
22. Mfcd00271236
23. Zinc34031047
24. Akos028109412
25. As-60043
26. Androsta-4,16-dien-3-ol, (3.beta.)-
27. Hy-145567
28. Cs-0376082
29. Q20707597
| Molecular Weight | 272.4 g/mol |
|---|---|
| Molecular Formula | C19H28O |
| XLogP3 | 4.6 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 272.214015512 g/mol |
| Monoisotopic Mass | 272.214015512 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 476 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Intended for the acute treatment of social phobia.
Vomeropherin compounds are directly delivered to the nasal passages using either a metered nasal spray or a metered nasal aerosol. By virtue of the chemoreceptors location in the nasal passages, direct connections to the hypothalamus and limbic system and the ability of our compounds to act locally, vomeropherins do not need to achieve systemic absorption and distribution. This provides a significant therapeutic advantage over traditional therapeutics targeted at the hypothalamus and limbic system that require access to systemic circulation and must cross the blood-brain barrier followed by uptake into the brain to exert effects.
Absorption
Absorbed following nasal administration.
There is little information available on the mechanism of action of vomeropherins. These compounds are delivered to the nasal passages and bind to chemoreceptors that in turn affect the hypothalamus and the limbic system.
Drugs in Development
Details:
PH94B (fasedienol) is a first-in-class, rapid-onset investigational pherine nasal spray. It is being evaluated for the acute treatment of social anxiety disorder.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable September 23, 2024
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Vistagen Initiates PALISADE-4 Phase 3 Study of Fasedienol for Social Anxiety Disorder
Details : PH94B (fasedienol) is a first-in-class, rapid-onset investigational pherine nasal spray. It is being evaluated for the acute treatment of social anxiety disorder.
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
September 23, 2024
Details:
PH94B (fasedienol) is a first-in-class, rapid-onset investigational pherine nasal spray. It is being evaluated for the acute treatment of social anxiety disorder.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable January 04, 2024
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Vistagen Initiates PALISADE-3 Study of Fasedienol for Social Anxiety Disorder Treatment
Details : PH94B (fasedienol) is a first-in-class, rapid-onset investigational pherine nasal spray. It is being evaluated for the acute treatment of social anxiety disorder.
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 04, 2024
Details:
PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons in the brain.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: PH94B
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable October 08, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons ...
Product Name : PH94B
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 08, 2023
Details:
PH94B (aloradine) is a rapid-onset investigational pherine nasal spray that regulates olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable October 01, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PH94B (aloradine) is a rapid-onset investigational pherine nasal spray that regulates olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct a...
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 01, 2023
Details:
PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons in the brain.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable July 08, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons ...
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 08, 2023
Details:
PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons in the brain.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable March 30, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons ...
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 30, 2023
Details:
PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons in the brain.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable March 22, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PH94B (fasedienol) is a pherine nasal spray that regulates the olfactory-amygdala neural circuits of fear and anxiety and attenuates the tone of the sympathetic ANS, without systemic distribution, potentiation of GABA-A or direct activity on CNS neurons ...
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 22, 2023
Details:
Vistagen intends to use the proceeds for research and development associated with development of its product candidates, including its Phase 3 program for fasedienol, an investigational neuroactive pherine nasal spray, for anxiety in adults with social anxiety disorder.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: BVF Partners
Deal Size: $100.0 million Upfront Cash: Undisclosed
Deal Type: Public Offering February 10, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : BVF Partners
Deal Size : $100.0 million
Deal Type : Public Offering
Vistagen Announces Pricing of $100 Million Underwritten Offering
Details : Vistagen intends to use the proceeds for research and development associated with development of its product candidates, including its Phase 3 program for fasedienol, an investigational neuroactive pherine nasal spray, for anxiety in adults with social a...
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 10, 2023
Details:
Through the acquisition, Vistagen owns all intellectual property rights to PH94B (aloradine), in Phase 3 development for SAD and Phase 2 development for AjDA, and PH10, in clinical development for MDD, as well as three additional candidates in earlier stages of development.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: PH94B
Study Phase: Phase IIIProduct Type: Other Small Molecule
Sponsor: VistaGen Therapeutics
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Acquisition February 02, 2023
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Partner/Sponsor/Collaborator : VistaGen Therapeutics
Deal Size : Undisclosed
Deal Type : Acquisition
Vistagen Announces Closing of Pherin Pharmaceuticals Acquisition
Details : Through the acquisition, Vistagen owns all intellectual property rights to PH94B (aloradine), in Phase 3 development for SAD and Phase 2 development for AjDA, and PH10, in clinical development for MDD, as well as three additional candidates in earlier st...
Product Name : PH94B
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 02, 2023
Details:
PH94B (aloradine) is a first-in-class synthetic investigational neurosteroid developed from proprietary compounds called pherines. PH94B is a nasal spray administered at microgram-level doses and designed to achieve rapid-onset anti-anxiety, or anxiolytic, effects.
Lead Product(s): Fasedienol
Therapeutic Area: Psychiatry/Psychology Brand Name: Aloradine
Study Phase: Phase IIProduct Type: Other Small Molecule
Sponsor: Inapplicable
Deal Size: Inapplicable Upfront Cash: Inapplicable
Deal Type: Inapplicable December 30, 2022
Lead Product(s) : Fasedienol
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Partner/Sponsor/Collaborator : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : PH94B (aloradine) is a first-in-class synthetic investigational neurosteroid developed from proprietary compounds called pherines. PH94B is a nasal spray administered at microgram-level doses and designed to achieve rapid-onset anti-anxiety, or anxiolyti...
Product Name : Aloradine
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 30, 2022
FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]Digital Content
NEWS #PharmaBuzz
ABOUT THIS PAGE
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PharmaCompass offers a list of Fasedienol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fasedienol manufacturer or Fasedienol supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fasedienol manufacturer or Fasedienol supplier.
PharmaCompass also assists you with knowing the Fasedienol API Price utilized in the formulation of products. Fasedienol API Price is not always fixed or binding as the Fasedienol Price is obtained through a variety of data sources. The Fasedienol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Fasedienol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fasedienol, including repackagers and relabelers. The FDA regulates Fasedienol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fasedienol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Fasedienol supplier is an individual or a company that provides Fasedienol active pharmaceutical ingredient (API) or Fasedienol finished formulations upon request. The Fasedienol suppliers may include Fasedienol API manufacturers, exporters, distributors and traders.
Fasedienol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Fasedienol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fasedienol GMP manufacturer or Fasedienol GMP API supplier for your needs.
A Fasedienol CoA (Certificate of Analysis) is a formal document that attests to Fasedienol's compliance with Fasedienol specifications and serves as a tool for batch-level quality control.
Fasedienol CoA mostly includes findings from lab analyses of a specific batch. For each Fasedienol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Fasedienol may be tested according to a variety of international standards, such as European Pharmacopoeia (Fasedienol EP), Fasedienol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fasedienol USP).
