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Chemistry

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Also known as: Evp-6124, 550999-75-2, Evp 6124, Evp6124, N-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide, Chembl2151572
Molecular Formula
C16H17ClN2OS
Molecular Weight
320.8  g/mol
InChI Key
SSRDSYXGYPJKRR-ZDUSSCGKSA-N
FDA UNII
5FI5376A0X

EVP-6124
Encenicline has been investigated for the treatment of Cognition, Schizophrenia, Alzheimer's Disease, Cardiac Repolarization, and Central Nervous System Diseases.
1 2D Structure

EVP-6124

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide
2.1.2 InChI
InChI=1S/C16H17ClN2OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9H2,(H,18,20)/t13-/m0/s1
2.1.3 InChI Key
SSRDSYXGYPJKRR-ZDUSSCGKSA-N
2.1.4 Canonical SMILES
C1CN2CCC1C(C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl
2.1.5 Isomeric SMILES
C1CN2CCC1[C@H](C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl
2.2 Other Identifiers
2.2.1 UNII
5FI5376A0X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. N-(7-chloro-n-quinuclidin-3-yl)benzo(b)thiophene-2-carboxamide

2.3.2 Depositor-Supplied Synonyms

1. Evp-6124

2. 550999-75-2

3. Evp 6124

4. Evp6124

5. N-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide

6. Chembl2151572

7. 5fi5376a0x

8. Mt4666

9. Mt-4666

10. Benzo(b)thiophene-2-carboxamide, N-(3r)-1-azabicyclo(2.2.2)oct-3-yl-7-chloro-

11. (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide

12. 7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide

13. Unii-5fi5376a0x

14. Encenicline [usan:inn]

15. Frm-6124

16. I33

17. Encenicline [inn]

18. Encenicline (usan/inn)

19. Encenicline [usan]

20. Encenicline [who-dd]

21. Schembl744767

22. Gtpl6926

23. (r)-7-chloro-n-(quinuclidin-3-yl)benzo(b)thiophene-2-carboxamide

24. Dtxsid701025836

25. Ex-a3984

26. Bdbm50393255

27. Mfcd23381267

28. Zinc95579362

29. Cs-0933

30. Db11726

31. Ncgc00378871-01

32. Hy-15430

33. D10626

34. A913801

35. Q19904062

36. (r)-7-chloro-n-(quinuclidine-3-yl)benzo[b]thiophene-2-carboxamide

37. N-((3r)-1-azabicyclo(2.2.2)oct-3-yl)-7-chloro-1-benzothiophene-2-carboxamide

38. N-(3r)-1-azabicyclo[2.2.2]oct-3-yl-7-chlorobenzo[b]thiophene-2-carboxamide

39. 1275596-71-8

2.4 Create Date
2010-07-06
3 Chemical and Physical Properties
Molecular Weight 320.8 g/mol
Molecular Formula C16H17ClN2OS
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass320.0750120 g/mol
Monoisotopic Mass320.0750120 g/mol
Topological Polar Surface Area60.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity413
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

Encenicline, a selective, orally active, alpha 7 Nicotinic Acetylcholine Receptor agonist (alpha 7 NAchR agonist). Encenicline may have a similar mechanism of action to GTS-21. Auditory sensory gating, a biological measurement of the ability to suppress the evoked response to the second of two auditory stimuli, is diminished in people with schizophrenia. Deficits in sensory gating are associated with attentional impairment, and may contribute to cognitive symptoms and perceptual disturbances. This inhibitory process, which involves the alpha(7) nicotinic receptor mediated release of gamma-aminobutyric acid (GABA) by hippocampal interneurons, represents a potential new target for therapeutic intervention in schizophrenia.


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Looking for 1275596-71-8 / EVP-6124 API manufacturers, exporters & distributors?

EVP-6124 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of EVP-6124 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right EVP-6124 manufacturer or EVP-6124 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred EVP-6124 manufacturer or EVP-6124 supplier.

PharmaCompass also assists you with knowing the EVP-6124 API Price utilized in the formulation of products. EVP-6124 API Price is not always fixed or binding as the EVP-6124 Price is obtained through a variety of data sources. The EVP-6124 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

EVP-6124

Synonyms

550999-75-2, Evp 6124, Evp6124, N-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide, Chembl2151572, 5fi5376a0x

Cas Number

1275596-71-8

Unique Ingredient Identifier (UNII)

5FI5376A0X

About EVP-6124

Encenicline has been investigated for the treatment of Cognition, Schizophrenia, Alzheimer's Disease, Cardiac Repolarization, and Central Nervous System Diseases.

EVP 6124 Manufacturers

A EVP 6124 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of EVP 6124, including repackagers and relabelers. The FDA regulates EVP 6124 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. EVP 6124 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

EVP 6124 Suppliers

A EVP 6124 supplier is an individual or a company that provides EVP 6124 active pharmaceutical ingredient (API) or EVP 6124 finished formulations upon request. The EVP 6124 suppliers may include EVP 6124 API manufacturers, exporters, distributors and traders.

EVP 6124 GMP

EVP 6124 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of EVP 6124 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right EVP 6124 GMP manufacturer or EVP 6124 GMP API supplier for your needs.

EVP 6124 CoA

A EVP 6124 CoA (Certificate of Analysis) is a formal document that attests to EVP 6124's compliance with EVP 6124 specifications and serves as a tool for batch-level quality control.

EVP 6124 CoA mostly includes findings from lab analyses of a specific batch. For each EVP 6124 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

EVP 6124 may be tested according to a variety of international standards, such as European Pharmacopoeia (EVP 6124 EP), EVP 6124 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (EVP 6124 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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