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Ethyl Loflazepate

Ethyl Loflazepate

Synopsis, Chemistry

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Also known as: Victan, Meilax, 29177-84-2, Ethyl fluclozepate, Cm 6912, Loflazepic acid, ethyl ester

Molecular Formula

C₁₈H₁₄ClFN₂O₃

Molecular Weight

360.8 g/mol

InChI Key

CUCHJCMWNFEYOM-UHFFFAOYSA-N

FDA UNII

VJB5FW9W9J

1 2D Structure

Ethyl Loflazepate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate

2.1.2 InChI

InChI=1S/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23)

2.1.3 InChI Key

CUCHJCMWNFEYOM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC(=O)C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F

2.2 Other Identifiers

2.2.1 UNII

VJB5FW9W9J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cm 6912

2. Ethyl Flucozepate

3. Victan

2.3.2 Depositor-Supplied Synonyms

1. Victan

2. Meilax

3. 29177-84-2

4. Ethyl Fluclozepate

5. Cm 6912

6. Loflazepic Acid, Ethyl Ester

7. Vjb5fw9w9j

8. Ethyl 7-chloro-5-(o-fluorophenyl)-2,3-dihydro-2-oxo-1h-1,4-benzodiazepine-3-carboxylate

9. 1h-1,4-benzodiazepine-3-carboxylic Acid, 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-oxo-, Ethyl Ester

10. Ethylis Loflazepas

11. Ethyl Loflazepate [inn:jan]

12. Loflazepate D'ethyle

13. Loflazepato De Etilo

14. Ethylis Loflazepas [inn-latin]

15. Loflazepate D'ethyle [inn-french]

16. Loflazepato De Etilo [inn-spanish]

17. Einecs 249-489-4

18. Unii-vjb5fw9w9j

19. Brn 0765264

20. Dea No. 2758

21. Meilax (tn)

22. Cm-6912

23. Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate

24. 5-25-08-00124 (beilstein Handbook Reference)

25. Ethyl Loflazepate (jan/inn)

26. Schembl156702

27. Ethyl Loflazepate [mi]

28. Ethyl Loflazepate [inn]

29. Ethyl Loflazepate [jan]

30. Chembl1213460

31. Chebi:31573

32. Dtxsid60865475

33. Ethyl Loflazepate [mart.]

34. Ethyl Loflazepate [who-dd]

35. Db01545

36. Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1h-1,4-benzodiazepine-3-carboxylate

37. D01293

38. Q5404460

39. Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1h-1,4-benzodiazepine-3-carboxylate #

40. (e)-ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1h-benzo[e][1,4]diazepine-3-carboxylate

41. Ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-2,3-dihydro-1h-benzo[e][1,4]diazepine-3-carboxylate

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₄ClFN₂O₃
Molecular Weight	360.8 g/mol
XLogP3	2.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	360.0676982 g/mol
Monoisotopic Mass	360.0676982 g/mol
Topological Polar Surface Area	67.8 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	556
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

4.2 ATC Code

N - Nervous system

N05 - Psycholeptics

N05B - Anxiolytics

N05BA - Benzodiazepine derivatives

N05BA18 - Ethyl loflazepate