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Chemistry

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Also known as: Esomeprazole sodium, Esomeprazole (sodium), H199/18 sodium, Esomeprazole (as sodium), Esomeprazole sodium [usan], 161796-78-7
Molecular Formula
C17H18N3NaO3S
Molecular Weight
367.4  g/mol
InChI Key
RYXPMWYHEBGTRV-JIDHJSLPSA-N
FDA UNII
L2C9GWQ43H

Esomeprazole Sodium
The S-isomer of omeprazole.
1 2D Structure

Esomeprazole Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
2.1.2 InChI
InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3;/q-1;+1/t24-;/m0./s1
2.1.3 InChI Key
RYXPMWYHEBGTRV-JIDHJSLPSA-N
2.1.4 Canonical SMILES
CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
2.1.5 Isomeric SMILES
CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
2.2 Other Identifiers
2.2.1 UNII
L2C9GWQ43H
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Esomeprazole

2. Esomeprazole Magnesium

3. Esomeprazole Potassium

4. Esomeprazole Sodium

5. Esomeprazole Strontium

6. Esomeprazole Strontium Anhydrous

7. Nexium

8. Strontium, Esomeprazole

2.3.2 Depositor-Supplied Synonyms

1. Esomeprazole Sodium

2. Esomeprazole (sodium)

3. H199/18 Sodium

4. Esomeprazole (as Sodium)

5. Esomeprazole Sodium [usan]

6. 161796-78-7

7. Esomeprazole Sodium (usan)

8. (s)-omeprazole Sodium Salt

9. L2c9gwq43h

10. Sodium;5-methoxy-2-[(s)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

11. Nexium Iv (tn)

12. 1h-benzimidazole, 5-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt

13. 5-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)-1h-benzimidazole, Sodium Salt

14. Chembl1200470

15. Esomeprazole Sodium [vandf]

16. Esomeprazole Sodium [mart.]

17. Esomeprazole Sodium [who-dd]

18. S2233

19. Ccg-268253

20. Esomeprazole Sodium [orange Book]

21. Esomeprazole Sodium [ep Monograph]

22. Hy-17023

23. O0560

24. 1h-benzimidazole, 6-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt (1:1)

25. D04056

26. Q-100194

27. Q27282619

28. 5-methoxy-2-[(s)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1h-benzimidazole Sodium Salt

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 367.4 g/mol
Molecular Formula C17H18N3NaO3S
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass367.09665690 g/mol
Monoisotopic Mass367.09665690 g/mol
Topological Polar Surface Area81.5 Ų
Heavy Atom Count25
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameEsomeprazole sodium
Drug LabelThe active ingredient in esomeprazole sodium for injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H-benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isome...
Active IngredientEsomeprazole sodium
Dosage FormInjectable
RouteIntravenous
Strengtheq 20mg base/vial; eq 40mg base/vial
Market StatusPrescription
CompanySun Pharma Global

2 of 2  
Drug NameEsomeprazole sodium
Drug LabelThe active ingredient in esomeprazole sodium for injection is (S)-5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1 H-benzimidazole sodium, a proton pump inhibitor that inhibits gastric acid secretion. Esomeprazole is the S-isome...
Active IngredientEsomeprazole sodium
Dosage FormInjectable
RouteIntravenous
Strengtheq 20mg base/vial; eq 40mg base/vial
Market StatusPrescription
CompanySun Pharma Global

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]

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15-Jan-2022
27-May-2025
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DOSAGE - INJECTABLE;INTRAVENOUS - EQ 20MG BAS...DOSAGE - INJECTABLE;INTRAVENOUS - EQ 20MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21689

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DOSAGE - INJECTABLE;INTRAVENOUS - EQ 40MG BAS...DOSAGE - INJECTABLE;INTRAVENOUS - EQ 40MG BASE/VIAL

USFDA APPLICATION NUMBER - 21689

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ABOUT THIS PAGE

Looking for 161796-78-7 / Esomeprazole Sodium API manufacturers, exporters & distributors?

Esomeprazole Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Esomeprazole Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Esomeprazole Sodium manufacturer or Esomeprazole Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Esomeprazole Sodium manufacturer or Esomeprazole Sodium supplier.

PharmaCompass also assists you with knowing the Esomeprazole Sodium API Price utilized in the formulation of products. Esomeprazole Sodium API Price is not always fixed or binding as the Esomeprazole Sodium Price is obtained through a variety of data sources. The Esomeprazole Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Esomeprazole Sodium

Synonyms

Esomeprazole (sodium), H199/18 sodium, Esomeprazole (as sodium), Esomeprazole sodium [usan], 161796-78-7, Esomeprazole sodium (usan)

Cas Number

161796-78-7

Unique Ingredient Identifier (UNII)

L2C9GWQ43H

About Esomeprazole Sodium

The S-isomer of omeprazole.

Esomeprazole Sodium Manufacturers

A Esomeprazole Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Esomeprazole Sodium, including repackagers and relabelers. The FDA regulates Esomeprazole Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Esomeprazole Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Esomeprazole Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Esomeprazole Sodium Suppliers

A Esomeprazole Sodium supplier is an individual or a company that provides Esomeprazole Sodium active pharmaceutical ingredient (API) or Esomeprazole Sodium finished formulations upon request. The Esomeprazole Sodium suppliers may include Esomeprazole Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Esomeprazole Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Esomeprazole Sodium USDMF

A Esomeprazole Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Esomeprazole Sodium active pharmaceutical ingredient (API) in detail. Different forms of Esomeprazole Sodium DMFs exist exist since differing nations have different regulations, such as Esomeprazole Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Esomeprazole Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Esomeprazole Sodium USDMF includes data on Esomeprazole Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Esomeprazole Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Esomeprazole Sodium suppliers with USDMF on PharmaCompass.

Esomeprazole Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Esomeprazole Sodium Drug Master File in Korea (Esomeprazole Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Esomeprazole Sodium. The MFDS reviews the Esomeprazole Sodium KDMF as part of the drug registration process and uses the information provided in the Esomeprazole Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Esomeprazole Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Esomeprazole Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Esomeprazole Sodium suppliers with KDMF on PharmaCompass.

Esomeprazole Sodium CEP

A Esomeprazole Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Esomeprazole Sodium Certificate of Suitability (COS). The purpose of a Esomeprazole Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Esomeprazole Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Esomeprazole Sodium to their clients by showing that a Esomeprazole Sodium CEP has been issued for it. The manufacturer submits a Esomeprazole Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Esomeprazole Sodium CEP holder for the record. Additionally, the data presented in the Esomeprazole Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Esomeprazole Sodium DMF.

A Esomeprazole Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Esomeprazole Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Esomeprazole Sodium suppliers with CEP (COS) on PharmaCompass.

Esomeprazole Sodium WC

A Esomeprazole Sodium written confirmation (Esomeprazole Sodium WC) is an official document issued by a regulatory agency to a Esomeprazole Sodium manufacturer, verifying that the manufacturing facility of a Esomeprazole Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Esomeprazole Sodium APIs or Esomeprazole Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Esomeprazole Sodium WC (written confirmation) as part of the regulatory process.

click here to find a list of Esomeprazole Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

Esomeprazole Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Esomeprazole Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Esomeprazole Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Esomeprazole Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Esomeprazole Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Esomeprazole Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Esomeprazole Sodium suppliers with NDC on PharmaCompass.

Esomeprazole Sodium GMP

Esomeprazole Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Esomeprazole Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Esomeprazole Sodium GMP manufacturer or Esomeprazole Sodium GMP API supplier for your needs.

Esomeprazole Sodium CoA

A Esomeprazole Sodium CoA (Certificate of Analysis) is a formal document that attests to Esomeprazole Sodium's compliance with Esomeprazole Sodium specifications and serves as a tool for batch-level quality control.

Esomeprazole Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Esomeprazole Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Esomeprazole Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Esomeprazole Sodium EP), Esomeprazole Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Esomeprazole Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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