Find Enpatoran manufacturers, exporters & distributors on PharmaCompass

Enpatoran

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0PROSPECTS

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

API REF. PRICE (USD/KG)

$ 0

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Regulatory FDF Prices

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

API

FDF

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 2101938-42-3, M5049, Enpatoran [inn], Enpatoran [usan], Unii-7cz390v26x, 7cz390v26x

Molecular Formula

C₁₆H₁₅F₃N₄

Molecular Weight

320.31 g/mol

InChI Key

BJXYHBKEQFQVES-NWDGAFQWSA-N

FDA UNII

7CZ390V26X

ENPATORAN is a small molecule drug with a maximum clinical trial phase of II (across all indications) and has 5 investigational indications.

1 2D Structure

Enpatoran

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile

2.1.2 InChI

InChI=1S/C16H15F3N4/c17-16(18,19)11-6-12(21)9-23(8-11)14-4-3-10(7-20)15-13(14)2-1-5-22-15/h1-5,11-12H,6,8-9,21H2/t11-,12+/m0/s1

2.1.3 InChI Key

BJXYHBKEQFQVES-NWDGAFQWSA-N

2.2 Other Identifiers

2.2.1 UNII

7CZ390V26X

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 2101938-42-3

2. M5049

3. Enpatoran [inn]

4. Enpatoran [usan]

5. Unii-7cz390v26x

6. 7cz390v26x

7. 5-[(3r,5s)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile

8. M-5049

9. Enpatoran [who-dd]

10. 5-((3r,5s)-3-amino-5-trifluoromethylpiperidin-1-yl)quinoline-8-carbonitrile

11. 8-quinolinecarbonitrile, 5-((3r,5s)-3-amino-5-(trifluoromethyl)-1-piperidinyl)-

12. 5-((3r,5s)-3-amino-5-(trifluoromethyl)piperidin-1-yl)quinoline-8-carbonitrile

13. Refchem:136984

14. Tlr 7/8 Antagonist M5049

15. Tlr 7/8 Inhibitor M5049

16. M 5049

17. Enpatoran [usan:inn]

18. Who 11880

19. 5-[(3~{r},5~{s})-3-azanyl-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile

20. Enpatoran (usan/inn)

21. Orb1298016

22. Chembl4802159

23. Schembl18980030

24. Schembl29722092

25. Gtpl11307

26. Glxc-23927

27. Ex-a5509

28. Mfcd34471096

29. Akos040759872

30. Compound 73 [wo2017106607a1]

31. Ms-24729

32. Hy-134581

33. Cs-0145642

34. D12261

35. F96161

36. Qlh

2.4 Create Date

2017-08-04

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₁₅F₃N₄
Molecular Weight	320.31 g/mol
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	65.9
Heavy Atom Count	23
Formal Charge	0
Complexity	472
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 Mechanism of Action

M5049 is a small molecule Toll-like receptor (TLR)7 and TLR8 inhibitor. The drug blocks activation of TLR7/8, thereby stopping immune cell activation, inflammation, and the progression into a cyotkine storm. The drug is currently being investigated against COVID-19.

ABOUT THIS PAGE

Privacy policy
Terms and conditions
Disclaimers
Product listings are provided for informational purposes only. We do not supply or sell any products. Any products that may be covered by patent(s) are supplied solely for uses permitted under Section 107A of the Indian Patents Act and not for commercial sale.