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DRUG PRODUCT COMPOSITIONS0
Weekly News Recap #Phispers
1. Beta L 2',3' Dideoxy 5 Fluoro 3' Thiacytidine
2. Beta-l-2',3'-dideoxy-5-fluoro-3'-thiacytidine
3. Coviracil
4. Emtriva
1. 143491-57-0
2. Emtriva
3. Coviracil
4. (-)-ftc
5. 4-amino-5-fluoro-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1h)-one
6. 143491-54-7
7. 524w91
8. Bw-524w91
9. Ftc
10. Racivir
11. 4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
12. Bw524w91
13. (-)-2'-deoxy-5-fluoro-3'-thiacytidine
14. Ftc-(-)
15. Bw 524w91
16. (-)-emtricitabine
17. (2r-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1h)-pyrimidinone
18. (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine
19. Chebi:31536
20. 5-fluoro-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
21. Emtricitabine, (-)-
22. Psi-5004
23. 4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1h)-one
24. 145213-48-5
25. G70b4etf4s
26. Uls8902u4o
27. Emtritabine
28. Bw1592
29. (-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1h)-pyrimidin-2-one
30. 2',3'-dideoxy-5-fluoro-3'-thiacytidine
31. Ncgc00164564-01
32. (-)-(2r,5s)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
33. 2(1h)-pyrimidinone, 4-amino-5-fluoro-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, Rel-
34. 524-w-91
35. Psi 5004
36. Mfcd00870151
37. Ftc, Dl-
38. Coviracil(tm)
39. Drg-0208
40. 4-amino-5-fluoro-1-((2r,5s)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1h-pyrimidin-2-one
41. Rel-4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1h)-pyrimidinone
42. Emtriva(tm)
43. 2(1h)-pyrimidinone, 4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, Rel-
44. Emtricitabine (emtriva)
45. Smr002533604
46. Bw 1592
47. 2',3',5-ftc
48. Emtricitabine, (+/-)-
49. Hsdb 7337
50. 4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one
51. Ftc, (-)-
52. Unii-g70b4etf4s
53. Emtricitabine [usan:inn]
54. (-)-.beta.-l-ftc
55. Unii-uls8902u4o
56. Emtricitabinum
57. (+/-)-ftc
58. 2(1h)-pyrimidinone,4-amino-5-fluoro-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-
59. 2(1h)-pyrimidinone,4-amino-5-fluoro-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
60. Emtricitabine- Bio-x
61. Emtricitabine [mi]
62. Chembl885
63. Emtricitabine [inn]
64. Emtricitabine [jan]
65. 2(1h)-pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, Cis-
66. Dsstox_cid_20129
67. Dsstox_rid_79445
68. Emtricitabine [hsdb]
69. Emtricitabine [usan]
70. Dsstox_gsid_40129
71. Schembl39708
72. Emtricitabine [vandf]
73. Mls003882429
74. Mls006011556
75. Mls006011987
76. Emtricitabine [mart.]
77. Emtricitabine [usp-rs]
78. Emtricitabine [who-dd]
79. Emtricitabine [who-ip]
80. Dtxsid0040129
81. Emtricitabine [ema Epar]
82. Gtpl11244
83. Ex-a150
84. Hms2089i05
85. Hms3713l12
86. Emtricitabine [orange Book]
87. Zinc3629271
88. Tox21_112193
89. ((-))-ftc
90. Bdbm50107843
91. Cs1125
92. Ftc-((-))
93. Nsc804863
94. S1704
95. Atripla Component Emtricitabine
96. Descovy Component Emtricitabine
97. Emtricitabinum [who-ip Latin]
98. Odefsey Component Emtricitabine
99. Truvada Component Emtricitabine
100. Akos015853098
101. Akos015894950
102. Eviplera Component Emtricitabine
103. Stribild Component Emtricitabine
104. Am84393
105. Ccg-220615
106. Cs-1370
107. Db00879
108. Nsc-804863
109. 2',3'-dideoxy-3-thia-5-fluorocytidine
110. Descovy Component Of Emtricitabine
111. Emtricitabine Component Of Atripla
112. Emtricitabine Component Of Descovy
113. Emtricitabine Component Of Genvoya
114. Emtricitabine Component Of Odefsey
115. Emtricitabine Component Of Truvada
116. Ncgc00164564-06
117. Ncgc00164564-09
118. Ncgc00164564-10
119. 2(1h)-pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2r-cis)-
120. 2(1h)-pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, Cis-(+-)-
121. As-14099
122. Be165946
123. Emtricitabine Component Of Eviplera
124. Emtricitabine Component Of Stribild
125. Hy-17427
126. Cas-143491-57-0
127. E1007
128. Emtricitabine 100 Microg/ml In Acetonitrile
129. Sw220172-1
130. D01199
131. D72669
132. Ent-emtricitabine; Emtricitabine Ip Impurity D
133. Ab01275429-01
134. 491e570
135. Q422604
136. W-201247
137. W-201248
138. 2',3'-dideoxy-5-fluoro-3'-thiacytidine, Dl-
139. Z1739256297
140. .beta.-l-(-)-(2r,5s)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
141. 5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (2r,5s)
142. 2(1h)-pyrimidinone, 4-amino-5-fluoro-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-
143. 4-amino-5-fluoro-1-[(2s,5r)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1h)-pyrimidinone; (+)-2'-deoxy-3'-thia-5-fluorocytidine; (2s-cis)-4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1h)-pyrimidinone
144. 5-fluoro-(-)-l-2',3'-dideoxy-3'-thiacytidine; (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine; Emtricitabine; Emtriva
| Molecular Weight | 247.25 g/mol |
|---|---|
| Molecular Formula | C8H10FN3O3S |
| XLogP3 | -0.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 247.04269053 g/mol |
| Monoisotopic Mass | 247.04269053 g/mol |
| Topological Polar Surface Area | 113 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 374 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 4 | |
|---|---|
| Drug Name | Emtricitabine |
| PubMed Health | Emtricitabine (By mouth) |
| Drug Classes | Antiretroviral Agent |
| Drug Label | EMTRIVA is the brand name of emtricitabine, a synthetic nucleoside analog with activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.The chemical name of emtricitabine is 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiol... |
| Active Ingredient | Emtricitabine |
| Dosage Form | Capsule |
| Route | oral |
| Strength | 200mg |
| Market Status | Tentative Approval |
| Company | Matrix Labs; Aurobindo Pharma; Cipla |
| 2 of 4 | |
|---|---|
| Drug Name | Emtriva |
| PubMed Health | Emtricitabine (By mouth) |
| Drug Classes | Antiretroviral Agent |
| Drug Label | EMTRIVA is the brand name of emtricitabine, a synthetic nucleoside analog with activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.The chemical name of emtricitabine is 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiol... |
| Active Ingredient | Emtricitabine |
| Dosage Form | Capsule; Solution |
| Route | oral; Oral |
| Strength | 200mg; 10mg/ml |
| Market Status | Prescription |
| Company | Gilead |
| 3 of 4 | |
|---|---|
| Drug Name | Emtricitabine |
| PubMed Health | Emtricitabine (By mouth) |
| Drug Classes | Antiretroviral Agent |
| Drug Label | EMTRIVA is the brand name of emtricitabine, a synthetic nucleoside analog with activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.The chemical name of emtricitabine is 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiol... |
| Active Ingredient | Emtricitabine |
| Dosage Form | Capsule |
| Route | oral |
| Strength | 200mg |
| Market Status | Tentative Approval |
| Company | Matrix Labs; Aurobindo Pharma; Cipla |
| 4 of 4 | |
|---|---|
| Drug Name | Emtriva |
| PubMed Health | Emtricitabine (By mouth) |
| Drug Classes | Antiretroviral Agent |
| Drug Label | EMTRIVA is the brand name of emtricitabine, a synthetic nucleoside analog with activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.The chemical name of emtricitabine is 5-fluoro-1-(2R,5S)-[2-(hydroxymethyl)-1,3-oxathiol... |
| Active Ingredient | Emtricitabine |
| Dosage Form | Capsule; Solution |
| Route | oral; Oral |
| Strength | 200mg; 10mg/ml |
| Market Status | Prescription |
| Company | Gilead |
Antiviral Agents
National Library of Medicine's Medical Subject Headings. Emtricitabine. Online file (MeSH, 2014). Available from, as of November 19, 2013: https://www.nlm.nih.gov/mesh/2014/mesh_browser/MBrowser.html
Emtricitabine is used in conjunction with other antiretroviral agents for the treatment of HIV-1 infection in pediatric patients 12 years of age or older. The fixed combination containing emtricitabine and tenofovir (Truvada) can be used in conjunction with other antiretrovirals in children 12 years of age or older weighing at least 35 kg. For initial treatment of HIV-infected pediatric patients, the HHS Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children recommends antiretroviral therapy with at least 3 drugs, including either a PI or NNRTI with 2 NRTIs. When PI-based or NNRTI-based regimens are used in pediatric patients, emtricitabine and (abacavir (for individuals 3 months of age or older who test negative for the HLA-B*5701 allele), tenofovir (for adolescents 12 years of age or older at Tanner stage 4 or 5), or zidovudine) are preferred dual NRTI options. A dual NRTI combination of emtricitabine and lamivudine is not recommended, because of similar resistance profiles and minimal additive antiretroviral activity. A triple NRTI regimen that includes abacavir, tenofovir, and either lamivudine or emtricitabine or a triple NRTI regimen that includes tenofovir, didanosine, and either lamivudine or emtricitabine should not be used at any time in pediatric patients because of the high rate of early virologic failure reported in antiretroviral-naive adults.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 700
Emtricitabine has been evaluated in a randomized, open-label, multicenter study (study 303) in 440 previously treated adults (mean age: 42 years; 86% male; 64% white; 13% Hispanic; 21% African American; median baseline plasma HIV-1 RNA level: 1.7 log10 copies/mL; mean baseline CD4+ T-cell count: 527 cells/mm3) who had received a lamivudine-containing regimen that also included 2 other antiretrovirals (background regimen) for at least 12 weeks prior to study entry and had plasma HIV-1 levels of 400 copies/mL or less. Patients in this study were randomized to receive emtricitabine in conjunction with stavudine or zidovudine and PI or NNRTI or to continue their lamivudine-containing background regimen (i.e., lamivudine in conjunction with stavudine or zidovudine and a PI or NNRTI). At week 48, 77 and 67% of adults receiving the regimen that included emtricitabine and 82 and 72% of those receiving the regimen that included lamivudine had plasma HIV-1 RNA levels less than 400 or 50 copies/mL, respectively. Virologic failure (i.e., individuals who failed to achieve virologic suppression or experienced rebound after achieving virologic suppression) was reported in 7% of those receiving the emtricitabine-containing regimen and in 8% of those receiving the lamivudine-containing regimen at week 48. Administration of the emtricitabine-containing regimen resulted in a mean increase in CD4+ T-cell counts of 29 cells/mm3; administration of the lamivudine-containing regimen resulted in a mean increase in CD4+ T-cell counts of 61 cells/cu mm.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 700
Safety and efficacy of emtricitabine used in conjunction with other antiretrovirals have been evaluated in a randomized multicenter study in treatment-naive adults (study 301A). In this study, 571 HIV-infected adults (mean age: 36 years; 85% male; 52% white; 26% Hispanic; 16% African American; median baseline plasma HIV-1 RNA level: 4.9 log10 copies/mL; mean baseline CD4+ T-cell count: 318 cells/mm3) were randomized to receive emtricitabine or stavudine in conjunction with didanosine (delayed-release capsules) and efavirenz. Results of this study indicated that an initial regimen that includes emtricitabine in conjunction with didanosine and efavirenz is as effective as an initial regimen of stavudine in conjunction with didanosine and efavirenz. At week 48, 81 and 78% of adults receiving the regimen that included emtricitabine and 68 and 59% of those receiving the regimen that included stavudine had plasma HIV-1 RNA levels less than 400 or 50 copies/mL, respectively. Virologic failure (i.e., individuals who failed to achieve virologic suppression or experienced rebound after achieving virologic suppression) at week 48 was reported in 3% of those receiving the emtricitabine-containing regimen and in 11% of those receiving the stavudine-containing regimen. At week 48, increases in CD4+ T-cell counts were greater in patients receiving the regimen that included emtricitabine (mean increase of 168 cells/mm3) than in those receiving the regimen that included stavudine (mean increase of 134 cells/mm3).
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 700
For more Therapeutic Uses (Complete) data for EMTRICITABINE (7 total), please visit the HSDB record page.
Safety and efficacy of emtricitabine have been established for treatment of HIV-1 infection in children 3 months of age and older. The pharmacokinetics and safety of emtricitabine were evaluated in a dose-finding study in 20 neonates born to HIV-infected mothers.20 1 These neonates received zidovudine prophylaxis for 6 weeks. In addition, these neonates received 2 short courses of emtricitabine (3 mg/kg daily for 4 days per course) during the first 12 weeks of life. This dose was well tolerated and was not associated with any safety issues. Systemic exposure (area under the plasma concentration-time curve [AUC]) in infants 0-3 months of age receiving emtricitabine 3 mg/kg daily was similar to that reported in children 3 months to 17 years of age receiving emtricitabine 6 mg/kg daily. All neonates were HIV-1 negative at the end of the study (6 months postpartum); efficacy of emtricitabine for the prevention or treatment of HIV was not determined.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 703
Lactic acidosis and severe hepatomegaly with steatosis, including fatalities, have been reported in patients receiving nucleoside reverse transcriptase inhibitors (NRTIs), including emtricitabine, in conjunction with other antiretroviral agents. Most reported cases have involved women; obesity and long-term therapy with a nucleoside analog also may be risk factors.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 702
Caution should be observed when nucleoside reverse transcriptase inhibitors are used in patients with known risk factors for liver disease; however, lactic acidosis and severe hepatomegaly with steatosis have been reported in patients with no known risk factors. Emtricitabine therapy should be interrupted in any patient with clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity (signs of hepatotoxicity include hepatomegaly and steatosis even in the absence of marked increases in serum aminotransferase concentrations).
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 702
Prior to initiation of emtricitabine therapy for the treatment of HIV-1 infection, patients should be tested for chronic hepatitis B virus (HBV). Emtricitabine is not indicated for the treatment of chronic HBV infection; safety and efficacy of the drug have not been established in patients with coexisting HBV and HIV infections. Exacerbations of HBV infection have been reported in HIV-infected patients following discontinuance of emtricitabine. Patients with HBV infection and HIV infection should be closely monitored with clinical and laboratory follow-up for at least several months after stopping emtricitabine therapy.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 702
For more Drug Warnings (Complete) data for EMTRICITABINE (13 total), please visit the HSDB record page.
Emtricitabine is indicated in combination with other medications for the treatment of HIV-1 infections; treatment of HIV-1 infections in pediatric patients 25-35kg, treatment of HIV-1 infections in adult patients 35kg, for pre exposure prophylaxis of HIV-1 in adolescent and adult patients excluding those who have receptive vaginal sex; treatment of HIV-1 infections in pediatric and adult patients 17kg, pre exposure prophylaxis in adolescents and adults 35kg; treatment of HIV-1 in patients 12 years and 35kg; treatment of HIV-1 in patients weighing 35kg; treatment of HIV-1 in patients weighing 25kg; and treatment of HIV-1 in patients weighing 40kg.
FDA Label
Emtriva is indicated for the treatment of HIV-1 infected adults and children in combination with other antiretroviral agents.
This indication is based on studies in treatment-naive patients and treatment-experienced patients with stable virological control. There is no experience of the use of Emtriva in patients who are failing their current regimen or who have failed multiple regimens.
When deciding on a new regimen for patients who have failed an antiretroviral regimen, careful consideration should be given to the patterns of mutations associated with different medicinal products and the treatment history of the individual patient. Where available, resistance testing may be appropriate.
Emtricitabine is a cytidine analog that competes with the natural substrate of HIV-1 reverse transcriptase to be incorporated into newly formed DNA, terminating its transcription. It is administered once daily so it has a long duration of action. Patients should be counselled regarding the risk of lactic acidosis and hepatomegaly with steatosis.
Anti-HIV Agents
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)
Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)
Reverse Transcriptase Inhibitors
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)
J05AF09
J05AF09
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
J - Antiinfectives for systemic use
J05 - Antivirals for systemic use
J05A - Direct acting antivirals
J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF09 - Emtricitabine
Absorption
Emtricitabine reaches a Cmax of 1.80.7g/mL with a Tmax of 1-2 hours, and has an AUC of 103.1g\*hr/mL. The bioavailability of emtricitabine capsules is 93% and the bioavailability of the oral solution is 75%. Taking emtricitabine with food decreases the Cmax by 29%.[L9019
Route of Elimination
Emtricitabine is 86% recovered in the urine and 14% recovered in feces. 13% of the dose is recovered in the urine as metabolites; 9% as 3'-sulfoxide diastereomers and 4% as 2'-O-glucuronide.
Volume of Distribution
The apparent central volume of distribution is 42.3L and the peripheral volume of distribution is 55.4L.
Clearance
Emtricitabine has an apparent elimination rate of 15.1L/h. This rate is closely linked to creatinine clearance.
Emtricitabine is rapidly and extensively absorbed following oral administration with peak plasma concentrations occurring at 1 to 2 hours post-dose. Following multiple dose oral administration of emtriva to 20 HIV-infected subjects, the (mean + or - SD) steady state plasma emtricitabine peak concentration (Cmax) was 1.8 + or 0.7 ug/mL and the area under the plasma concentration-time curve over a 24-hour dosing interval (AUC) was 10.0 + or - 3.1 hr/ug/mL. The mean steady state plasma trough concentration at 24 hours post-dose was 0.09 ug/mL. The mean absolute bioavailability of emtriva was 93%.
Physicians Desk Reference 65th ed. PDR Network, LLC, Montvale, NJ. 2011, p. 1154
In vitro binding of emtricitabine to human plasma proteins was <4% and independent of concentration over the range of 0.02 to 200 ug/mL. At peak plasma concentration, the mean plasma to blood drug concentration ratio was approximately 1.0 and the mean semen to plasma drug concentration ratio was approximately 4.0.
Physicians Desk Reference 65th ed. PDR Network, LLC, Montvale, NJ. 2011, p. 1155
Time to peak concentration: 1 to 2 hours post dose
Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 1265
Emtricitabine is distributed into human milk in low concentrations.
American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 703
For more Absorption, Distribution and Excretion (Complete) data for EMTRICITABINE (6 total), please visit the HSDB record page.
Emtricitabine is approximately 86% unmetabolized. Approximately 9% of a dose is metabolized to 3'-sulfoxide diastereomers, 4% to the 2'-O-glucuronide, and a minor amount is converted to 5-fluorocytosine.
The biotransformation of emtricitabine includes oxidation of the thiol moiety to form the 3'-sulfoxide diastereomers (approximately 9% of dose) and conjugation with glucuronic acid to form 2'-O-glucuronide (approximately 4% of dose). No other metabolites were identifiable. Emtricitabine is not metabolized by liver enzymes.
Thomson.Micromedex. Drug Information for the Health Care Professional. 25th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2005., p. 1265
The half life of emtricitabine is approximately 10 hours.
The plasma emtricitabine half-life is approximately 10 hours.
Physicians Desk Reference 65th ed. PDR Network, LLC, Montvale, NJ. 2011, p. 1155
Emtricitabine is a cytidine analog which, when phosphorylated to emtricitabine 5'-triphosphate, competes with deoxycytidine 5'-triphosphate for HIV-1 reverse transcriptase. As HIV-1 reverse transcriptase incorporates emtricitabine into forming DNA strands, new nucleotides are unable to be incorporated, leading to viral DNA chain termination. Inhibition of reverse transcriptase prevents transcription of viral RNA into DNA, therefore the virus is unable to incorporate its DNA into host DNA and replicate using host cell machinery. This reduces viral load.
Emtricitabine, a synthetic nucleoside analog of cytosine, is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination. Emtricitabine 5'-triphosphate is a weak inhibitor of mammalian DNA polymerase alpha, beta, epsilon and mitochondrial DNA polymerase gamma.
Physicians Desk Reference 65th ed. PDR Network, LLC, Montvale, NJ. 2011, p. 1155
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USFDA APPLICATION NUMBER - 208215
DOSAGE - TABLET;ORAL - 200MG;EQ 25MG BASE;EQ ...DOSAGE - TABLET;ORAL - 200MG;EQ 25MG BASE;EQ 25MG BASE
USFDA APPLICATION NUMBER - 208351
DOSAGE - TABLET;ORAL - EQ 30MG BASE;120MG;EQ ...DOSAGE - TABLET;ORAL - EQ 30MG BASE;120MG;EQ 15MG BASE
USFDA APPLICATION NUMBER - 210251
DOSAGE - TABLET;ORAL - EQ 50MG BASE;200MG;EQ ...DOSAGE - TABLET;ORAL - EQ 50MG BASE;200MG;EQ 25MG BASE
USFDA APPLICATION NUMBER - 210251
DOSAGE - CAPSULE;ORAL - 200MG
USFDA APPLICATION NUMBER - 21500
DOSAGE - TABLET;ORAL - 100MG;150MG
USFDA APPLICATION NUMBER - 21752
DOSAGE - TABLET;ORAL - 133MG;200MG
USFDA APPLICATION NUMBER - 21752
DOSAGE - TABLET;ORAL - 167MG;250MG
USFDA APPLICATION NUMBER - 21752
DOSAGE - TABLET;ORAL - 200MG;300MG
USFDA APPLICATION NUMBER - 21752
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