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Chemistry

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Also known as: 13048-33-4, Hexamethylene diacrylate, Kayarad hdda, 1,6-hexamethylene diacrylate, Sartomer 238, Hdoda
Molecular Formula
C12H18O4
Molecular Weight
226.27  g/mol
InChI Key
FIHBHSQYSYVZQE-UHFFFAOYSA-N
FDA UNII
FY751V5MMY

EM-221
1 2D Structure

EM-221

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-prop-2-enoyloxyhexyl prop-2-enoate
2.1.2 InChI
InChI=1S/C12H18O4/c1-3-11(13)15-9-7-5-6-8-10-16-12(14)4-2/h3-4H,1-2,5-10H2
2.1.3 InChI Key
FIHBHSQYSYVZQE-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
FY751V5MMY
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Hexamethylene Diacrylate

2. Hexanediol Diacrylate

2.3.2 Depositor-Supplied Synonyms

1. 13048-33-4

2. Hexamethylene Diacrylate

3. Kayarad Hdda

4. 1,6-hexamethylene Diacrylate

5. Sartomer 238

6. Hdoda

7. Viscoat 230

8. Hexamethylene Acrylate

9. Photomer 4017

10. Hexamethylene Glycol Diacrylate

11. Setalux Uv 2243

12. Sartomer Sr 238

13. Hdda

14. Nk Ester A Hd

15. Acrylic Acid, Hexamethylene Ester

16. Hexaneglycol Diarcylate

17. 2-propenoic Acid, 1,6-hexanediyl Ester

18. Nk Ester A-hd

19. Sr 238

20. 1,6-hexanediol Di-2-propenoate

21. C 716

22. Fy751v5mmy

23. Dtxsid9025401

24. Laromer Hdda

25. Kayarad Ks-hdda

26. New Frontier Hdda

27. Actilane 425

28. Sartomer Sr-238

29. Photomer 4017f

30. 2-propenoic Acid, 1,1'-(1,6-hexanediyl) Ester

31. Hexamethyleneglycol Diacrylate

32. Genomer 1223

33. Hexaneglycol Diacrylate

34. Agisyn 2816

35. M-200 (acrylate)

36. Dtxcid705401

37. Em-221tf

38. Sr-238ns

39. 1,6-hexamethylenediol Diacrylate

40. Light Acrylate 1,6hx-a

41. Light Acrylate Sr-238f

42. 1,6hx-a

43. Sr-238f

44. 1,6-hexanediyl Diacrylate

45. Em-221

46. Sm-626

47. Sr-238

48. Sr-2389

49. M 200

50. V-230

51. Refchem:73627

52. 235-921-9

53. Hexanediol Diacrylate

54. Hexane-1,6-diyl Diacrylate

55. 6-prop-2-enoyloxyhexyl Prop-2-enoate

56. 1,6-bis(acryloyloxy)hexane

57. Mfcd00008631

58. Hexane-1,6-diyl Bisacrylate

59. Hexane-1,6-diyl Diacrylate (stabilized With Mehq)

60. Cas-13048-33-4

61. Hexanediol Diacrylate(9 Cp(25 Degrees C))

62. Ccris 4823

63. Hexamethylenediacrylate

64. Hsdb 6109

65. Einecs 235-921-9

66. Unii-fy751v5mmy

67. Brn 1870540

68. 1,6-hexanediol Diacrylate (stabilized With 100 Ppm Mehq) (>85%)

69. Ks-hdda

70. Nk Ester A-hd-n

71. 1,6-hexandiol Diacrylate

72. 1,6 Hexanediol Diacrylate

73. Hexamethylenediol Diacrylate

74. A-hd-n

75. Ec 235-921-9

76. C-6da

77. Schembl33725

78. 1,6-bis(acryloyloxy)hexane (stabilized With Mehq)

79. 1,6-hexanediol Diacrylate (stabilized With Mehq)

80. Light Ester 1.6hx-a

81. Chembl1530684

82. 6-(acryloyloxy)hexyl Acrylate #

83. 1,6-hexanediol Diacrylate, 90%

84. 1.6hx

85. Hexanediol Diacrylate (hdda)

86. Tox21_201349

87. Tox21_303168

88. Msk161342

89. Akos015904309

90. Hexamethylene Diacrylate, 1,6-

91. Ncgc00091257-01

92. Ncgc00091257-02

93. Ncgc00091257-03

94. Ncgc00091257-04

95. Ncgc00257183-01

96. Ncgc00258901-01

97. 1,6-hexanediol Diacrylate [hsdb]

98. As-75465

99. Db-254921

100. B2936

101. Cs-0158045

102. Ns00007428

103. 1,6-hexanediol Diacrylate, Technical Grade, 80%

104. F242822

105. 1,6-bis(acryloyloxy)hexane, (stabilized With Mehq)

106. Q1276266

107. 1,6-hexamethylene Diacrylate (1,6-hexanediol Diacrylate), Visc.5-8 Cps

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 226.27 g/mol
Molecular Formula C12H18O4
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area52.6
Heavy Atom Count16
Formal Charge0
Complexity219
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

Acrylates and methacrylates are detoxified predominantly via conjugation with glutathione via the Michael addition reaction or glutathione-S-transferase. They are also likely to be hydrolyzed via carboxylesterases. The lower molecular weight esters are rapidly metabolized and eliminated, therefore, will not likely cause cumulative toxicity. /Acrylates/

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V6 600


4.2 Mechanism of Action

...Dimethacrylates proved to be moderate to strong sensitizers in the guinea pig.

PMID:6839734 Van Der Walle HB et al; Contact Dermatitis 9(1): 10-20 (1983)


ABOUT THIS PAGE

Looking for 13048-33-4 / EM-221 API manufacturers, exporters & distributors?

EM-221 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of EM-221 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right EM-221 manufacturer or EM-221 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred EM-221 manufacturer or EM-221 supplier.

API | Excipient name

EM-221

Synonyms

13048-33-4, Hexamethylene diacrylate, Kayarad hdda, 1,6-hexamethylene diacrylate, Sartomer 238, Hdoda

Cas Number

13048-33-4

Unique Ingredient Identifier (UNII)

FY751V5MMY

EM-221 Manufacturers

A EM-221 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of EM-221, including repackagers and relabelers. The FDA regulates EM-221 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. EM-221 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

EM-221 Suppliers

A EM-221 supplier is an individual or a company that provides EM-221 active pharmaceutical ingredient (API) or EM-221 finished formulations upon request. The EM-221 suppliers may include EM-221 API manufacturers, exporters, distributors and traders.

EM-221 GMP

EM-221 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of EM-221 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right EM-221 GMP manufacturer or EM-221 GMP API supplier for your needs.

EM-221 CoA

A EM-221 CoA (Certificate of Analysis) is a formal document that attests to EM-221's compliance with EM-221 specifications and serves as a tool for batch-level quality control.

EM-221 CoA mostly includes findings from lab analyses of a specific batch. For each EM-221 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

EM-221 may be tested according to a variety of international standards, such as European Pharmacopoeia (EM-221 EP), EM-221 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (EM-221 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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