Elapegademase-lvlr

Synopsis, Chemistry

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1 API Suppliers, 1 JDMF

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Application Number

230MF10020

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Ella peg Ade Ma Ze at 6925 Guion Ro...

Issue/Submission Date

2018-02-05

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Looking for 1709806-75-6 / Elapegademase API manufacturers, exporters & distributors?

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API | Excipient name

Elapegademase

Synonyms

Revcovi, Elapegademase-lvlr, Elapegademase [inn], Unii-9r3d3y0uhs, Elapegademase [usan:inn], 9r3d3y0uhs

Cas Number

1709806-75-6

About Elapegademase

Elapegademase is a recombinant form of the enzyme adenosine deaminase (rADA), based on the bovine amino acid sequence and covalently conjugated, with a succinimidyl carbamate linker, to monomethoxypolyethylene glycol (mPEG) (SC-PEG rADA), that can be used as an enzyme replacement agent for the treatment of adenosine deaminase severe combined immune deficiency (ADA-SCID). Upon intramuscular administration, elapegademase, as an exogenous source of ADA, replaces the deficient ADA enzyme and acts in the same manner as the endogenous enzyme. ADA is involved in purine metabolism and mainly catalyzes the irreversible hydrolytic deamination of adenosine or deoxyadenosine to inosine or deoxyinosine, respectively, as well as several naturally occurring methylated adenosine compounds. Elapegademase decreases toxic levels of adenosine and deoxyadenosine nucleotides, increases lymphocyte levels and helps maintain the proper functioning of immune cells. Elevated adenosine levels, as seen in ADA deficiency, induce apoptosis and inhibit the differentiation of thymocytes, resulting in T-lymphopenia. Low levels of deoxyadenosine and adenosine play key roles in the regulation of lymphocyte levels and the proper functioning of immune cells.

Elapegademase-lvlr Manufacturers

A Elapegademase-lvlr manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Elapegademase-lvlr, including repackagers and relabelers. The FDA regulates Elapegademase-lvlr manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Elapegademase-lvlr API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Elapegademase-lvlr Suppliers

A Elapegademase-lvlr supplier is an individual or a company that provides Elapegademase-lvlr active pharmaceutical ingredient (API) or Elapegademase-lvlr finished formulations upon request. The Elapegademase-lvlr suppliers may include Elapegademase-lvlr API manufacturers, exporters, distributors and traders.

click here to find a list of Elapegademase-lvlr suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Elapegademase-lvlr Manufacturers | Traders | Suppliers

We have 1 companies offering Elapegademase-lvlr

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Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.