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    Eflornithine
    Also known as: 68278-23-9, Eflornithine hcl, Dfmo, Dl-alpha-difluoromethylornithine hydrochloride, Eflornithinehydrochloride, 2-(difluoromethyl)-dl-ornithine monohydrochloride
    Molecular Formula
    C6H13ClF2N2O2
    Molecular Weight
    218.63  g/mol
    InChI Key
    VKDGNNYJFSHYKD-UHFFFAOYSA-N
    FDA UNII
    UO07O10TCJ
    An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway.
    1 2D Structure

    Eflornithine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2,5-diamino-2-(difluoromethyl)pentanoic acid;hydrochloride
    2.1.2 InChI
    InChI=1S/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H
    2.1.3 InChI Key
    VKDGNNYJFSHYKD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(CC(C(F)F)(C(=O)O)N)CN.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    UO07O10TCJ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Alpha Difluoromethyl Ornithine

    2. Alpha Difluoromethylornithine

    3. Alpha-difluoromethyl Ornithine

    4. Alpha-difluoromethylornithine

    5. Difluoromethylornithine

    6. Dl Alpha Difluoromethylornithine

    7. Dl-alpha-difluoromethylornithine

    8. Eflornithine

    9. Eflornithine Monohydrochloride, Monohydrate

    10. Mdl 71,782 A

    11. Mdl-71,782 A

    12. Mdl71,782 A

    13. Ornidyl

    14. Ornithine, Alpha-difluoromethyl

    15. Rmi 71782

    16. Vaniqa

    2.3.2 Depositor-Supplied Synonyms

    1. 68278-23-9

    2. Eflornithine Hcl

    3. Dfmo

    4. Dl-alpha-difluoromethylornithine Hydrochloride

    5. Eflornithinehydrochloride

    6. 2-(difluoromethyl)-dl-ornithine Monohydrochloride

    7. Eflornithine Hydrochloride Anhydrous

    8. Dfmo Hcl

    9. Eflornithine (hydrochloride)

    10. Dfmo Hydrochloride

    11. 2,5-diamino-2-(difluoromethyl)pentanoic Acid Hydrochloride

    12. Vaniqa

    13. Dfmo Hcl;eflornithine Hcl

    14. Uo07o10tcj

    15. Mls000069341

    16. 2,5-diamino-2-(difluoromethyl)pentanoic Acid;hydrochloride

    17. D,l-alpha-difluoromethylornithine Hydrochloride

    18. Nsc-270295

    19. H-alpha-difluoro-me-dl-orn-oh Hcl Ho

    20. Ncgc00093850-01

    21. Smr000058442

    22. .alpha.-dfmo Hcl

    23. Dsstox_cid_25765

    24. Dsstox_rid_81107

    25. Eflornithine . Hcl . Ho;dfmo . Hcl . Ho;alpha-difluoromethylornithine . Hcl . Ho

    26. Dsstox_gsid_45765

    27. Dfmo;mdl71782;rmi71782;alpha-difluoromethylornithine

    28. Dl-ornithine, Monohydrochloride

    29. Cas-96020-91-6

    30. Ccris 5805

    31. Nsc-337250

    32. Einecs 269-532-0

    33. Unii-uo07o10tcj

    34. Sr-01000076229

    35. 2-(difluoromethyl)-dl-ornithine Hydrochloride

    36. 2-(difluoromethyl)-dl-ornithine Hcl

    37. Dl-ornithine, 2-(difluoromethyl)-, Monohydrochloride

    38. Nsc 270295

    39. Nsc 337250

    40. Opera_id_46

    41. Eflornithine Hydrocloride

    42. Ornithine, 2-(difluoromethyl)-, Monohydrochloride

    43. Mls001332583

    44. Chembl536971

    45. Schembl3022583

    46. (rs)-eflornithine Hydrochloride

    47. Hy-b0744a

    48. Dtxsid601019072

    49. L-eflornithine Hydrochloride

    50. Bcp11748

    51. Dl-alpha-difluoromethylornithine Hcl

    52. Tox21_111224

    53. Tox21_500429

    54. Ac-388

    55. Mfcd00274036

    56. Nsc270295

    57. Akos015895186

    58. Tox21_111224_1

    59. Ccg-221733

    60. Eflornithine Hydrochloride [mi]

    61. Ks-1261

    62. Lp00429

    63. 2-(difluoromethyl)ornithine Hydrochloride

    64. Ncgc00015316-05

    65. Ncgc00261114-01

    66. Dl-

    67. A-difluoromethylornithine Hydrochloride

    68. E0947

    69. Eu-0100429

    70. Ft-0630774

    71. Dl-2-(difluoromethyl)-ornithine Hydrochloride

    72. H-alpha-difluoro-me-dl-orn-oh . Hcl . Ho

    73. Dl- Alpha -difluoromethylornithine Hydrochloride

    74. 278e239

    75. A836071

    76. A836749

    77. Dl--difluoromethylornithine Hydrochloride Monohydrate

    78. Sr-01000076229-1

    79. Dl-alpha-difluoromethylornithine Hydrochloride Hydrate

    80. Q27291165

    81. 2,5-diamino-2-(difluoromethyl)pentanoic Acid,hydrochloride

    82. 2,5-bis(azanyl)-2-[bis(fluoranyl)methyl]pentanoic Acid Hydrochloride

    83. 2,5-diamino-2-(difluoromethyl)pentanoic Acid Hydrochloride;eflornithine Hcl

    84. 2,5-diamino-2-(difluoromethyl)pentanoic Acid, Monohydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 218.63 g/mol
    Molecular Formula C6H13ClF2N2O2
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count5
    Exact Mass218.0633617 g/mol
    Monoisotopic Mass218.0633617 g/mol
    Topological Polar Surface Area89.3 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity166
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of facial hirsutism in women.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Trypanocidal Agents

    Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (See all compounds classified as Trypanocidal Agents.)

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    Ornithine Decarboxylase Inhibitors

    Substances and drugs that inhibit or block the activity of ORNITHINE DECARBOXYLASE. (See all compounds classified as Ornithine Decarboxylase Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Decarboxylase Inhibitor [EPC]; Decarboxylase Inhibitors [MoA]; Antiprotozoal [EPC]
    5.3 ATC Code

    D11AX

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