Find Vecuronium Bromide manufacturers, exporters & distributors on PharmaCompass

DSSTox_CID_3736

DSSTox_CID_3736

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

19 API Suppliers, 6 USDMF, 1 JDMF, 1 EU WC, 4 NDC API, 15 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

INTERMEDIATES

5 Suppliers

5 Suppliers

DOSSIERs // Finished Dosage Formulations

47 Dossiers, 25 FDA Orange Book, 2 Europe, 5 South Africa, 15 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 12 SPI Pharma, 3 Roquette, 2 Kerry, 2 Microlex e.U, 2 Gangwal Healthcare, 2 Gangwal Chemicals, 1 BASF, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Rochem International Inc, 1 Sigachi Industries, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Ingredion Pharma Solutions, 1 DKSH, 1 Pfanstiehl

EXCIPIENTS BY APPLICATIONS

18 Fillers, Diluents & Binders, 10 Direct Compression, 10 Chewable & Orodispersible Aids, 9 Taste Masking, 4 Co-Processed Excipients, 3 Disintegrants & Superdisintegrants, 3 Parenteral, 3 Granulation, 1 API Stability Enhancers, 1 Thickeners and Stabilizers

GLOBAL SALES INFORMATION

1 Finished Drug Prices

1 Finished Drug Prices

MARKET PLACE

3 APIs, 4 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

2 EDQM Standards, 5 USP Standards, 5 Other Ref. Standards

DIGITAL CONTENT

12 News

12 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

18,109

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 50700-72-6, Norcuron, Org nc 45, Vecuronii bromidum, Bromuro de vecuronio, Vecuronium (bromide)

Molecular Formula

C₃₄H₅₇BrN₂O₄

Molecular Weight

637.7 g/mol

InChI Key

VEPSYABRBFXYIB-PWXDFCLTSA-M

FDA UNII

7E4PHP5N1D

Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.

1 2D Structure

DSSTox_CID_3736

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;bromide

2.1.2 InChI

InChI=1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1

2.1.3 InChI Key

VEPSYABRBFXYIB-PWXDFCLTSA-M

2.1.4 Canonical SMILES

CC(=O)OC1CC2CCC3C(C2(CC1N4CCCCC4)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]

2.1.5 Isomeric SMILES

CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]

2.2 Other Identifiers

2.2.1 UNII

7E4PHP5N1D

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bromide, Vecuronium

2. Citrate, Vecuronium

3. Hydrobromide, Vecuronium

4. Hydrochloride, Vecuronium

5. Maleate, Vecuronium

6. Nc 45

7. Nc-45

8. Nc45

9. Norcuron

10. Org Nc 45

11. Org Nc45

12. Org-nc 45

13. Org-nc-45

14. Org-nc45

15. Orgnc 45

16. Orgnc45

17. Phosphate, Vecuronium

18. Vecuronium

19. Vecuronium Bromide, Quaternary Ion

20. Vecuronium Citrate

21. Vecuronium Hydrobromide

22. Vecuronium Hydrochloride

23. Vecuronium Maleate

24. Vecuronium Phosphate

2.3.2 Depositor-Supplied Synonyms

1. 50700-72-6

2. Norcuron

3. Org Nc 45

4. Vecuronii Bromidum

5. Bromuro De Vecuronio

6. Vecuronium (bromide)

7. Bromure De Vecuronium

8. Org-nc 45

9. 7e4php5n1d

10. Acetate;bromide

11. Chebi:9940

12. Musculax

13. Nsc-759184

14. 1-(3alpha,17beta-dihydroxy-2beta-piperidino-5alpha-androstan-16beta,5alpha-yl)-1-methylpiperidinium Bromide, Diacetate

15. Dsstox_cid_3736

16. (+)-1-(3,17-diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium Bromide

17. Dsstox_rid_77174

18. Dsstox_gsid_23736

19. [(2s,3s,10s,13s,16s,17r)-17-acetyloxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl] Acetate;bromide

20. [(2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-17-acetyloxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl] Acetate;bromide

21. Nc-45

22. 1-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide Hydrate

23. Cas-50700-72-6

24. Vecuronii Bromidum [inn-latin]

25. Ncgc00167467-01

26. Bromure De Vecuronium [inn-french]

27. Bromuro De Vecuronio [inn-spanish]

28. Einecs 256-723-9

29. Unii-7e4php5n1d

30. Vecronium Bromide

31. Norcuron (tn)

32. [(2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-17-acetyloxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]

33. Mfcd00867762

34. Vecuronium Bromide [usan:usp:inn:ban:jan]

35. 5alpha-androstan-3alpha,17beta-diol, 16beta-pipecolinio-2beta-piperidino-,bromide,diacetate

36. Schembl22250

37. Mls001424317

38. Piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl)-1-methyl-, Bromide

39. Vecuronium Bromide [mi]

40. Chembl1200629

41. Dtxsid1023736

42. Vecuronium Bromide [inn]

43. Vecuronium Bromide [jan]

44. Hy-b0118a

45. Vecuronium For System Suitability

46. Vecuronium Bromide [usan]

47. Hms2052i21

48. Hms3715l15

49. Hms3884c15

50. Vecuronium Bromide [vandf]

51. Vecuronium Bromide [mart.]

52. 1-[(1s,2s,4s,5s,7s,10r,11s,13s,14r,15s)-5,14-bis(acetyloxy)-2,15-dimethyl-4-(piperidin-1-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-13-yl]-1-methylpiperidin-1-ium Bromide

53. Bcp06528

54. Vecuronium Bromide (jan/usp/inn)

55. Vecuronium Bromide [usp-rs]

56. Vecuronium Bromide [who-dd]

57. Tox21_112471

58. Akos005145904

59. Akos007930694

60. Tox21_112471_1

61. Ac-2000

62. Ccg-101147

63. Cs-1881

64. Nc00397

65. Nsc 759184

66. Vecuronium Bromide [ep Impurity]

67. Vecuronium Bromide [orange Book]

68. Ncgc00167467-03

69. Vecuronium Bromide [ep Monograph]

70. 1-((2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-3,17-diacetoxy-10,13-dimethyl-2-(piperidin-1-yl)hexadecahydro-1h-cyclopenta[a]phenanthren-16-yl)-1-methylpiperidin-1-ium Bromide

71. Ds-12625

72. Piperidinium, 1-(3-alpha,17-beta-diacetoxy-2-beta-piperidino-5-alpha-androstan-16-beta-yl)-1-methyl-, Bromide

73. Smr000471625

74. Vecuronium Bromide [usp Monograph]

75. S1405

76. V0120

77. D00767

78. Pancuronium Bromide Impurity, Vecuronium Bromide -

79. Sr-01000763634

80. Pancuronium Bromide Impurity D [ep Impurity]

81. Q-101014

82. Sr-01000763634-3

83. Q27108523

84. Z1551429734

85. Vecuronium Bromide, European Pharmacopoeia (ep) Reference Standard

86. Pancuronium Bromide Impurity, Vecuronium Bromide - [usp Impurity]

87. Vecuronium Bromide, United States Pharmacopeia (usp) Reference Standard

88. 1-(3,17-diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium Bromide

89. Vecuronium Bromide, Pharmaceutical Secondary Standard; Certified Reference Material

90. Vecuronium For Peak Identification, European Pharmacopoeia (ep) Reference Standard

91. Vecuronium For System Suitability, European Pharmacopoeia (ep) Reference Standard

92. (2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane Bromide

93. (2beta,3alpha,5alpha,16beta,17beta)-3,17-diacetoxy-16-(1-methylpiperidinium-1-yl)-2-(piperidin-1-yl)androstane Bromide

94. 1-((2s,3s,5s,10s,13s,16s,17r)-3,17-diacetoxy-10,13-dimethyl-2-(piperidin-1-yl)hexadecahydro-1h-cyclopenta[a]phenanthren-16-yl)-1-methylpiperidin-1-ium Bromide

95. 1-((2s,3s,5s,10s,13s,16s,17r)-3,17-diacetoxy-10,13-dimethyl-2-(piperidin-1-yl)hexadecahydro-1h-cyclopenta[a]phenanthren-16-yl)-1-methylpiperidin-1-iumbromide

96. 1-(3.alpha.,17.beta.-dihydroxy-2.beta.-piperidino-5.alpha.-androstan-16.beta.,5.alpha.-yl)-1-methylpiperidinium Bromide, Diacetate

97. 1-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide

98. 1-[3alpha,17beta-bis(acetoxy)-2beta-(1-piperidinyl)-5alpha-androstan-16beta-yl]-1-methylpiperidinium Bromide

99. Piperidinium, 1-((2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl)-1-methyl-, Bromide

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₃₄H₅₇BrN₂O₄
Molecular Weight	637.7 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	636.35017 g/mol
Monoisotopic Mass	636.35017 g/mol
Topological Polar Surface Area	55.8 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	958
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Vecuronium bromide
Drug Label	Vecuronium Bromide for Injection is a nondepolarizing neuromuscular blocking agent of intermediate duration, chemically designated as 1-(3,17-Dihydroxy-2-piperidino-5- androstan-16,5-yl)-1-methylpiperidinium bromide, diacetate. The struct...
Active Ingredient	Vecuronium bromide
Dosage Form	Injectable
Route	Injection
Strength	10mg/vial; 20mg/vial
Market Status	Prescription
Company	Bedford; Hospira; Teva Pharms Usa; Sun Pharma Global; Mustafa Nevzat; Agila Speclts

2 of 2
Drug Name	Vecuronium bromide
Drug Label	Vecuronium Bromide for Injection is a nondepolarizing neuromuscular blocking agent of intermediate duration, chemically designated as 1-(3,17-Dihydroxy-2-piperidino-5- androstan-16,5-yl)-1-methylpiperidinium bromide, diacetate. The struct...
Active Ingredient	Vecuronium bromide
Dosage Form	Injectable
Route	Injection
Strength	10mg/vial; 20mg/vial
Market Status	Prescription
Company	Bedford; Hospira; Teva Pharms Usa; Sun Pharma Global; Mustafa Nevzat; Agila Speclts

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Neuromuscular Nondepolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)

Nicotinic Antagonists

Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Nondepolarizing Neuromuscular Blocker [EPC]; Neuromuscular Nondepolarizing Blockade [PE]