Find Nedocromilo manufacturers, exporters & distributors on PharmaCompass

DSSTox_CID_3356

DSSTox_CID_3356

Synopsis, Chemistry

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: 69049-73-6, Fpl 59002, 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, Nedocromilo, Nedocromilum, Fpl-59002

Molecular Formula

C₁₉H₁₇NO₇

Molecular Weight

371.3 g/mol

InChI Key

RQTOOFIXOKYGAN-UHFFFAOYSA-N

FDA UNII

0B535E0BN0

A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including EOSINOPHILS; NEUTROPHILS; MACROPHAGES; MAST CELLS; MONOCYTES; AND PLATELETS.

Nedocromil is a Mast Cell Stabilizer. The physiologic effect of nedocromil is by means of Decreased Histamine Release.

1 2D Structure

DSSTox_CID_3356

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid

2.1.2 InChI

InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)

2.1.3 InChI Key

RQTOOFIXOKYGAN-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCC1=C2C(=CC3=C1OC(=CC3=O)C(=O)O)C(=O)C=C(N2CC)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

0B535E0BN0

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid

2. Alocril

3. Brionil

4. Calcium, Nedocromil

5. Cetimil

6. Fpl 59002

7. Fpl-59002

8. Fpl59002

9. Halamid

10. Irtan

11. Nedocromil Calcium

12. Nedocromil Sodium

13. Nedocromil, Calcium Salt (1:1)

14. Nedocromil, Disodium Salt

15. Nedocromil, Disodium Salt, Hydrate

16. Rapitil

17. Sodium, Nedocromil

18. Tilad

19. Tilade

20. Tilaire

21. Tilavist

2.3.2 Depositor-Supplied Synonyms

1. 69049-73-6

2. Fpl 59002

3. 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid

4. Nedocromilo

5. Nedocromilum

6. Fpl-59002

7. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid

8. Chebi:7492

9. 0b535e0bn0

10. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano(3,2-g)chinolin-2,8-dicarbonsaeure

11. Ncgc00182073-02

12. Nedocromilum [latin]

13. Nedocromilo [spanish]

14. Dsstox_cid_3356

15. 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4h-pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid

16. Dsstox_rid_76990

17. Dsstox_gsid_23356

18. Cas-69049-73-6

19. Nedocromil [usan:inn:ban]

20. Unii-0b535e0bn0

21. Fpl59002

22. Nedocromil [mi]

23. Nedocromil [inn]

24. Nedocromil (usan/inn)

25. Nedocromil [usan]

26. Nedocromil [vandf]

27. Chembl746

28. Schembl4611

29. 4h-pyrano(3,2-g)quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-

30. Nedocromil [who-dd]

31. Bidd:gt0716

32. Gtpl7607

33. Dtxsid7023356

34. Nedocromil, >=98% (hplc)

35. Ex-a098

36. Bcp22724

37. Zinc3782807

38. Tox21_113148

39. Mfcd00864606

40. 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic Acid

41. Akos016014051

42. Tox21_113148_1

43. Db00716

44. Ncgc00182073-03

45. Ncgc00182073-07

46. Ac-30178

47. As-56153

48. Hy-13448

49. Db-055217

50. Ft-0630782

51. C07255

52. D05129

53. 049n736

54. L001326

55. Q416706

56. Sr-01000944506

57. Sr-01000944506-1

58. 9-ethyl-4,6-dioxo-10-propylpyrano[5,6-g]quinoline-2,8-dicarboxylic Acid

59. 9-ethyl-4,6-dioxo-10-propyl-4h,6h,9h-chromeno[7,6-b]pyridine-2,8-dicarboxylic Acid

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₁₇NO₇
Molecular Weight	371.3 g/mol
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	371.10050188 g/mol
Monoisotopic Mass	371.10050188 g/mol
Topological Polar Surface Area	121 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	753
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	Alocril
PubMed Health	Nedocromil
Drug Classes	Antiasthma, Mast Cell Stabilizer, Ophthalmologic Agent
Active Ingredient	Nedocromil sodium
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	2%
Market Status	Prescription
Company	Allergan

4.2 Drug Indication

For the treatment of mild to moderate asthma

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Nedocromil is a anti-inflammatory agent and can be administered directly to the bronchial mucosa. It has significant inhibitory effect on allergen-induced early and late asthmatic reactions and on bronchial hyperresponsiveness.

5.2 MeSH Pharmacological Classification

Anti-Asthmatic Agents

Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)

Mast Cell Stabilizers

Compounds that prevent the release of inflammatory mediators from MAST CELLS. (See all compounds classified as Mast Cell Stabilizers.)

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

NEDOCROMIL

5.3.2 FDA UNII

0B535E0BN0

5.3.3 Pharmacological Classes

Established Pharmacologic Class [EPC] - Mast Cell Stabilizer

5.4 ATC Code

R - Respiratory system

R01 - Nasal preparations

R01A - Decongestants and other nasal preparations for topical use

R01AC - Antiallergic agents, excl. corticosteroids

R01AC07 - Nedocromil

R - Respiratory system

R03 - Drugs for obstructive airway diseases

R03B - Other drugs for obstructive airway diseases, inhalants

R03BC - Antiallergic agents, excl. corticosteroids

R03BC03 - Nedocromil

S - Sensory organs

S01 - Ophthalmologicals

S01G - Decongestants and antiallergics

S01GX - Other antiallergics

S01GX04 - Nedocromil

5.5 Absorption, Distribution and Excretion

Absorption

Low

Route of Elimination

It is not metabolized and is eliminated primarily unchanged in urine (70%) and feces (30%).

5.6 Metabolism/Metabolites

Nedocromil is not metabolized after IV administration and is excreted unchanged.

5.7 Biological Half-Life

~3.3 hours

5.8 Mechanism of Action

Nedocromil has been shown to inhibit the in vitro activation of, and mediator release from, a variety of inflammatory cell types associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. Nedocromil inhibits activation and release of inflammatory mediators such as histamine, prostaglandin D2 and leukotrienes c4 from different types of cells in the lumen and mucosa of the bronchial tree. These mediators are derived from arachidonic acid metabolism through the lipoxygenase and cyclo-oxygenase pathways. The mechanism of action of nedocromil may be due partly to inhibition of axon reflexes and release of sensory neuropeptides, such as substance P, neurokinin A, and calcitonin-geneñrelated peptides. The result is inhibition of bradykinin-induced bronchoconstriction. Nedocromil does not posess any bronchodilator, antihistamine, or corticosteroid activity.