DSSTox_CID_3302

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

28 API Suppliers, 12 USDMF, 2 CEP/COS, 3 EU WC, 2 KDMF, 18 NDC API, 18 Listed Suppliers

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

DOSSIERs // Finished Dosage Formulations

76 Dossiers, 39 FDA Orange Book, 23 Europe, 7 Canada, 7 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - 20MG/ML, INJECTABLE;INJECTION - 40MG/ML, INJECTABLE;INJECTION - 80MG/ML

INJECTABLE;INJECTION - 20MG/ML
INJECTABLE;INJECTION - 40MG/ML
INJECTABLE;INJECTION - 80MG/ML

RELATED EXCIPIENT COMPANIES

Suppliers, 6 Seppic, 6 Actylis, 3 Nanjing Well Pharmaceutical, 3 Gangwal Chemicals, 1 Finar, 1 Jai Radhe Sales, 1 Nanjing Bold Chemical, 1 BASF

EXCIPIENTS BY APPLICATIONS

11 Solubilizers, 10 Parenteral, 6 Topical, 3 Emulsifying Agents, 2 Film Formers & Plasticizers, 2 Surfactant & Foaming Agents, 1 Co-Processed Excipients, 1 Direct Compression, 1 Rheology Modifiers, 1 API Stability Enhancers, 1 Thickeners and Stabilizers, 1 Lubricants & Glidants

GLOBAL SALES INFORMATION

16 US Medicaid Prescriptions, 13 Finished Drug Prices

MARKET PLACE

8 APIs, 4 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

4 EDQM Standards, 1 USP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

10 News

10 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

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API REF. PRICE (USD / KG)

2,781

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

2.00

Annual Reports

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

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Other Listed Suppliers

SERVICES

Also known as: Depo-medrol, 53-36-1, M-predrol, Depo-medrate, Medrol acetate, Depo-medrone

Molecular Formula

C₂₄H₃₂O₆

Molecular Weight

416.5 g/mol

InChI Key

PLBHSZGDDKCEHR-LFYFAGGJSA-N

FDA UNII

43502P7F0P

Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.

1 2D Structure

DSSTox_CID_3302

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

2.1.2 InChI

InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,19-,21+,22-,23-,24-/m0/s1

2.1.3 InChI Key

PLBHSZGDDKCEHR-LFYFAGGJSA-N

2.1.4 Canonical SMILES

CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)C)O

2.1.5 Isomeric SMILES

C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)C)O

2.2 Other Identifiers

2.2.1 UNII

43502P7F0P

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Acetyl Methylprednisolone

2. Acetyl-methylprednisolone

3. Depo Medrol

4. Depo Medrone

5. Depo-medrol

6. Depo-medrone

7. Methylprednisolone 21 Acetate

8. Methylprednisolone Acetate, (11beta,16alpha)-isomer

9. Methylprednisolone Acetate, (11beta,16beta)-isomer

10. Methylprednisolone-21-acetate

2.3.2 Depositor-Supplied Synonyms

1. Depo-medrol

2. 53-36-1

3. M-predrol

4. Depo-medrate

5. Medrol Acetate

6. Depo-medrone

7. Methylprednisolone 21-acetate

8. Depometicort

9. Depomedrone

10. Mepred

11. Medrol Enpak

12. Depo-medrin

13. 6alpha-methylprednisolone Acetate

14. D-med

15. Urbason Crystal Suspension

16. Depo-methylprednisolone Acetate

17. 6alpha-methylprednisolone 21-acetate

18. Depmedalone 40

19. Depmedalone 80

20. Methyl Prednisolone Acetate

21. U 8210

22. 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate

23. Nsc-48985

24. 6alpha-methyl Prednisolone 21-acetate

25. Chebi:6889

26. Nsc 48985

27. 43502p7f0p

28. Depo-methylprednisolone

29. Unidrol

30. Lemod Depo

31. (6alpha,11beta)-11,17-dihydroxy-6-methyl-3,20-dioxopregna-1,4-dien-21-yl Acetate

32. Solsolona [inj.]

33. Ubrason [inj.]

34. [2-[(6s,8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

35. Depot-medrol

36. Solsolona

37. Ubrason

38. Mls002667229

39. Einecs 200-171-3

40. 6-methylprednisolone Acetate

41. 6.alpha.-methylprednisolone Acetate

42. Unii-43502p7f0p

43. 6.alpha.-methylprednisolone 21-acetate

44. Ncgc00159503-02

45. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6.alpha.,11.beta.)-

46. Depo-medrol (tn)

47. Methylprednisolone Acetate [usp:jan]

48. Component Of Neo-medrol

49. Dsstox_cid_3302

50. Methylprednisolon-21-acetat

51. Dsstox_rid_76966

52. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-

53. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-

54. Dsstox_gsid_23302

55. Schembl13231

56. Mls001304003

57. Methyl Prednisolone 21-acetate

58. Chembl1364144

59. Dtxsid7023302

60. Methylprednisolone Ep Impurity J

61. 11.beta.,17,21-trihydroxy-6.alpha.-methylpregna-1,4-diene-3,20-dione 21-acetate

62. Bdbm233194

63. Hms2233n14

64. Hms3259l07

65. Nsc48985

66. 6?-methyl Prednisolone 21-acetate

67. Tox21_111722

68. S5973

69. Methylprednisolone Acetate (jan/usp)

70. Akos015969745

71. Zinc118912449

72. Nc00628

73. 6 Alpha -methylprednisolone 21-acetate

74. Cas-53-36-1

75. Methylprednisolone Acetate [jan]

76. Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-acetate

77. Hy-13681

78. Methylprednisolone Acetate [mart.]

79. Methylprednisolone Acetate [vandf]

80. Smr000718757

81. Methylprednisolone Acetate [usp-rs]

82. Methylprednisolone Acetate [who-dd]

83. Cs-0007549

84. M2635

85. C08179

86. D00979

87. D87728

88. Methylprednisolone Acetate [green Book]

89. Methylprednisolone Acetate [orange Book]

90. Ab00375925-05

91. Methylprednisolone Acetate [ep Monograph]

92. Methylprednisolone Acetate [usp Impurity]

93. Methylprednisolone Acetate For Peak Identification

94. Methylprednisolone Acetate For System Suitability

95. 200m356

96. Methylprednisolone Acetate [usp Monograph]

97. Methylprednisolone Impurity J [ep Impurity]

98. Methylprednisolone Acetate 100 Microg/ml In Methanol

99. Q27107351

100. Neo-medrol Acetate Component Methylprednisolone Acetate

101. Methylprednisolone Acetate Component Of Neo-medrol Acetate

102. Methylprednisolone Hydrogen Succinate Impurity C [ep Impurity]

103. Pregna-1,20-dione, 11.beta.,17,21-trihydroxy-6.alpha.-methyl-, 21-acetate

104. Pregna-1,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-, (6.alpha.,11.beta.)-

105. Methylprednisolone Acetate; 6?-methyl Prednisolone 21-acetate; Methylprednisolone Hydrogen Succinate Ep Impurity C; 11?,17-dihydroxy-6?-methyl-3,20-dioxopregna-1,4-dien21-yl Acetate; 21-acetoxy-11?,17-dihydroxy-6?-methylpregna-1,4-diene-3,20-dione

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.5 g/mol
XLogP3	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	416.21988874 g/mol
Monoisotopic Mass	416.21988874 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	858
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Depo-medrol
Drug Label	DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.Each mL of these preparations contains:Methylprednisolone...
Active Ingredient	Methylprednisolone acetate
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml; 80mg/ml; 40mg/ml
Market Status	Prescription
Company	Pharmacia And Upjohn

2 of 4
Drug Name	Methylprednisolone acetate
Drug Label	DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.Each mL of these preparations contains:Methylprednisolone...
Active Ingredient	Methylprednisolone acetate
Dosage Form	Injectable
Route	Injection
Strength	80mg/ml; 40mg/ml
Market Status	Prescription
Company	Teva Pharms Usa; Sandoz

3 of 4
Drug Name	Depo-medrol
Drug Label	DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.Each mL of these preparations contains:Methylprednisolone...
Active Ingredient	Methylprednisolone acetate
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml; 80mg/ml; 40mg/ml
Market Status	Prescription
Company	Pharmacia And Upjohn

4 of 4
Drug Name	Methylprednisolone acetate
Drug Label	DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL; 40 mg/mL; 80 mg/mL.Each mL of these preparations contains:Methylprednisolone...
Active Ingredient	Methylprednisolone acetate
Dosage Form	Injectable
Route	Injection
Strength	80mg/ml; 40mg/ml
Market Status	Prescription
Company	Teva Pharms Usa; Sandoz

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

Find Methylprednisolone Acetate manufacturers, exporters & distributors on PharmaCompass

DSSTox_CID_3302

DSSTox_CID_3302

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

28 API Suppliers

12 USDMF

2 CEP/COS

3 EU WC

2 KDMF

18 NDC API

18 Listed Suppliers

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Imports

DOSSIERs // Finished Dosage Formulations

76 Dossiers

39 FDA Orange Book

23 Europe

7 Canada

7 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - 20MG/ML

INJECTABLE;INJECTION - 40MG/ML

INJECTABLE;INJECTION - 80MG/ML

RELATED EXCIPIENT COMPANIES

Suppliers

6 Seppic

6 Actylis

3 Nanjing Well Pharmaceutical

3 Gangwal Chemicals

1 Finar

1 Jai Radhe Sales

1 Nanjing Bold Chemical

1 BASF

EXCIPIENTS BY APPLICATIONS

11 Solubilizers

10 Parenteral

6 Topical

3 Emulsifying Agents

2 Film Formers & Plasticizers

2 Surfactant & Foaming Agents

1 Co-Processed Excipients

1 Direct Compression

1 Rheology Modifiers

1 API Stability Enhancers

1 Thickeners and Stabilizers

1 Lubricants & Glidants

GLOBAL SALES INFORMATION

16 US Medicaid Prescriptions

13 Finished Drug Prices

MARKET PLACE

8 APIs

4 DOSSIERS // FDF

ANALYTICAL SOLUTION(s)

4 EDQM Standards

1 USP Standards

1 Other Ref. Standards

DIGITAL CONTENT

10 News

API SUPPLIERS

API REF. PRICE (USD / KG)

INTERMEDIATES

DOSSIERS // FDF

GLOBAL SALES (USD Million)

EXCIPIENTS

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

REF STANDARD

SERVICES

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