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1. Hydrochloride, Methaqualone
2. Methaqualone Hydrochloride
3. Metolquizolone
4. Optimil
5. Ortonal
6. Quaalude
1. Metolquizolone
2. 72-44-6
3. Quaalude
4. Methaqualoneinone
5. Metaqualon
6. Methaqualon
7. Ortonal
8. Cateudyl
9. Melsomin
10. Metakvalon
11. Tuazolone
12. Tuazole
13. Aqual
14. Dormigoa
15. Dormogen
16. Dormutil
17. Dorsedin
18. Fadormir
19. Holodorm
20. Methased
21. Mollinox
22. Mozambin
23. Nobedorm
24. Noctilene
25. Optinoxan
26. Orthonal
27. Parminal
28. Rouqualone
29. Sindesvel
30. Somberol
31. Somnomed
32. Hyminal
33. Hypocol
34. Hyptor
35. Ipnofil
36. Melsed
37. Motolon
38. Revonal
39. Roulone
40. Soverin
41. Torinal
42. Omnyl
43. Sonal
44. Sopor
45. Hyptor Base
46. Normi-nox
47. Citexal
48. Mequin
49. 3,4-dihydro-2-methyl-4-oxo-3-o-tolylquinazoline
50. Melsedin Base
51. Dormigoa-schlafmittel
52. Maoa
53. Pro-dorm
54. Rorer 148
55. Rorer 714
56. Somnafac
57. 2-methyl-3-(2-methylphenyl)-4(3h)-quinazolinone
58. Nethaqualone
59. Metachalon
60. 4(3h)-quinazolinone, 2-methyl-3-(2-methylphenyl)-
61. 2-methyl-3-o-tolyl-4-quinazolone
62. 2-methyl-3-tolyl-4-oxybensdiazine
63. Cn 38703
64. 2-methyl-3-o-tolyl-4(3h)-quinazolinone
65. Ci-705
66. Tr-495
67. Qz 2
68. R-148
69. 2-methyl-3-(2-tolyl)quinazol-4-one
70. Ric 272
71. 2-methyl-3-o-tolyl-4(3h)-chinazolone
72. Qz-2
73. 2-methyl-3-(2-methylphenyl)-4-quinazolinone
74. 2-methyl-3-(o-tolyl)-3,4-dihydro-4-quinazolinone
75. 2-methyl-3-o-tolyl-4(3h)-chinazolinon
76. 4(3h)-quinazolinone, 2-methyl-3-o-tolyl-
77. 7zkh8mqw6t
78. Mtq
79. Nsc-111388
80. Nsc-126877
81. Nsc-631628
82. Chebi:6821
83. 2-methyl-3-(2-methylphenyl)quinazolin-4-one
84. 2-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one
85. Ci 705
86. Nsc631628
87. Tr 495
88. 2-methyl-3-(o-tolyl)quinazolin-4-one
89. Metachalon [czech]
90. Ncgc00245236-02
91. Cn-38703
92. Dsstox_cid_3279
93. Dsstox_rid_76954
94. Dsstox_gsid_23279
95. Metacualona [inn-spanish]
96. Methaqualonum [inn-latin]
97. Hypcol
98. Tuazol
99. Cas-72-44-6
100. Wln: T66 Bvn Enj Cr B1& D1
101. Hsdb 3120
102. Einecs 200-780-4
103. Unii-7zkh8mqw6t
104. Nsc 111388
105. 2-methyl-3-o-tolyl-4(3h)-chinazolinon [german]
106. Brn 0211874
107. Reposil
108. Dea No. 2565
109. Methaqualone [usan:usp:inn:ban]
110. Methaqualone [mi]
111. 2-methyl-3-(o-tolyl)quinazolin-4(3h)-one
112. (.+/-.)-methaqualone
113. Methaqualone [inn]
114. Methaqualone [jan]
115. Methaqualone [hsdb]
116. Methaqualone [usan]
117. Methaqualone [vandf]
118. Schembl43892
119. Methaqualone [mart.]
120. 5-24-03-00132 (beilstein Handbook Reference)
121. Mls000678342
122. Methaqualone [who-dd]
123. Chembl282052
124. Dtxsid7023279
125. 4(3h)-quinazolinone, 2-methyl-3-(2-methylphenyl)-, (-)-
126. Hms2626l18
127. Methaqualone [ep Impurity]
128. Zinc2568176
129. Methaqualone 0.1 Mg/ml In Methanol
130. Methaqualone 1.0 Mg/ml In Methanol
131. Tox21_112502
132. Tox21_112869
133. 2-methyl-3-o-tolylquinazolin-4-one
134. Nsc111388
135. Nsc126877
136. Stl386501
137. Akos000509786
138. Db04833
139. Nsc-111388-
140. Ncgc00245236-01
141. Smr000285241
142. 2-methyl-3-(o-tolyl)-3h-quinazolin-4-one
143. 4(3h)-quinazolinone, 2-methyl-3-o--tolyl-
144. C07560
145. D00557
146. 2-methyl-3-(o-tolyl)-quinazoline-4 (3h)-one
147. Q423912
148. J-511183
149. (2-methyl-3-(o-tolyl)-3,4-dihydro-4-(quinazolinone)
150. Methaqualone Solution, 1 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 250.29 g/mol |
|---|---|
| Molecular Formula | C16H14N2O |
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 250.110613074 g/mol |
| Monoisotopic Mass | 250.110613074 g/mol |
| Topological Polar Surface Area | 32.7 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 390 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Sedatives, Nonbarbiturate
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
METHAQUALONE IS EFFECTIVE SEDATIVE & HYPNOTIC AGENT BUT LIKE SIMILAR DRUGS, MAY LOSE ITS EFFECTIVENESS BY 2ND WK OF CONTINUAL ADMIN. ... THIS DRUG IS PROBABLY SAFE FOR USE IN PATIENTS WITH HEREDITARY PORPHYRIA. /SRP: FORMER USE/
American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 159
Mildly toxic doses ... are similar to those of other sedative-hypnotics. Coma lasting 4 and 90 hours after ingestion of 3 and 7.5 g, respectively, occurred.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 597
MEDICATION: SEDATIVE-HYPNOTIC AGENT /SRP: FORMER USE/
American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 4th ed. Chicago: American Medical Association, 1980., p. 159
A sedative hypnotic, anticonvulsant, antitussive, and weak antihistamine. It may potentiate analgesic properties of opioids (e.g., codeine). /SRP: former use/
Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990., p. 727
COMA HAS OCCURRED AFTER 2.4 G & DEATH AFTER 8 G. ... MOST FATALITIES OCCUR IN PERSONS WHO HAVE ALSO INGESTED ETHANOL. ... ABUSERS EMPLOY DOSES OF 75 MG-2 G/DAY, WITH AVG OF ABOUT 725 MG. SEVERE GRAND MAL CONVULSIONS MAY OCCUR AFTER ABRUPT WITHDRAWAL FROM HIGH DOSES ...
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 367
... PATIENTS ON THE DRUG SHOULD BE WARNED AGAINST DRIVING CAR OR OPERATING HAZARDOUS MACHINERY. ... USED WITH CAUTION IN PATIENTS WITH DEPRESSION OR SUICIDAL TENDENCIES & THOSE WITH LIVER DYSFUNCTION.
Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1018
... CONTRAINDICATED IN WOMEN WHO ARE OR MAY BECOME PREGNANT; ITS SAFE USE IN CHILDREN HAS NOT BEEN ESTABLISHED. PSYCHOLOGICAL DEPENDENCE HAS OCCURRED ... PHYSICAL DEPENDENCE HAS NOW REACHED ALARMING PROPORTIONS & SOME AUTHORITIES BELIEVE THAT POTENTIAL FOR ... ADDICTION & ABUSE ARE AS SERIOUS AS THOSE OF BARBITURATES & HEROIN.
Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1018
... SHOULD NOT BE USED FOR PERIODS LONGER THAN 3 MO. FURTHERMORE IT SHOULD NOT BE PRESCRIBED FOR ADDICTION-PRONE PATIENTS.
Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1018
Reputed oral ingestions in adults of 8 to 20 g (100-200 mg/kg) have caused death. An adult who ingested 24 g (300 mg/kg) survived with supportive care.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 597
For the treatment of insomnia, and as a sedative and muscle relaxant.
Hypnotics and Sedatives
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)
N - Nervous system
N05 - Psycholeptics
N05C - Hypnotics and sedatives
N05CM - Other hypnotics and sedatives
N05CM01 - Methaqualone
IN MAN, 99% OF METHAQUALONE IS ABSORBED IN 2 HOURS. IN THE PLASMA, 70 TO 90% IS BOUND TO ALBUMIN. ... METABOLITES ... ARE MAINLY CONJUGATED AND EXCRETED IN THE URINE, BUT THE 4-HYDROXY METABOLITE IS EXCRETED INTO BILE. THE PHARMACOKINETICS IS THAT OF A TWO-COMPARTMENT SYSTEM, WITH A DISTRIBUTION HALF-LIFE OF LESS THAN 1 HOUR AND AN ELIMINATION HALF-LIFE OF 10 TO 40 HOURS.
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 367
AFTER ABSORPTION METHAQUALONE IS TAKEN UP BY ADIPOSE TISSUE & GRADUALLY RELEASED OVER PERIOD OF SEVERAL DAYS. AS IT IS RELEASED IT RAPIDLY UNDERGOES GLUCURONIDE CONJUGATION ... & IS EXCRETED EQUALLY IN URINE & FECES FOR UP TO 6-7 DAYS. IN TOXIC DOSES UNMETABOLIZED METHAQUALONE IS ALSO FOUND IN URINE.
Casarett, L.J., and J. Doull. Toxicology: The Basic Science of Poisons. New York: MacMillan Publishing Co., 1975., p. 649
BLOOD & URINE SAMPLES FROM ACUTELY INTOXICATED PATIENT STUDIED. 4 MAJOR MONOHYDROXYLATED METABOLITES FOUND CONJUGATED IN URINE. 2-METHYL-3-[2-(HYDROXYMETHYL)PHENYL]-4(3H)-QUINAZOLINONE FOUND UNCONJUGATED IN URINE & BLOOD.
KAZYAK L ET AL; J ANAL TOXICOL 3(2): 67 (1979)
URINARY EXCRETION OF 5 C-MONOHYDROXY METABOLITES & METHAQUALONE N-OXIDE MEASURED FOLLOWING ORAL ADMIN OF 250 MG TO GERIATRIC PT. TOTAL EXCRETION OF 6 METABOLITES IN 24 HR WAS APPROX ONE-HALF THAT IN GROUP OF YOUNG, HEALTHY ADULTS.
PMID:668786 REYNOLDS CN ET AL; EUR J CLIN PHARMACOL 13(4): 285 (1978)
For more Absorption, Distribution and Excretion (Complete) data for METHAQUALONE (10 total), please visit the HSDB record page.
MORE THAN 99% OF THE DRUG IS METABOLIZED BY THE HEPATIC MICROSOMAL SYSTEM, AND 4-HYDROXYMETHAQUALONE AND THE N'-OXIDE ARE THE MAJOR PRIMARY METABOLITES. AT LEAST EIGHT OTHER HYDROXYL METABOLITES ARE FORMED.
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 367
YIELDS 3-(3-HYDROXY-2-METHYLPHENYL)-2-METHYL-4(3H)-QUINAZOLINONE, 3-(4-HYDROXY-2-METHYLPHENYL)-2-METHYL-4(3H)-QUINAZOLINONE, & 6-HYDROXY-2-METHYL-3-(O-TOLYL)-4(3H)-QUINAZOLINONE IN MAN. /FROM TABLE/
Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. M-41
... METHAQUALONE ... GAVE 2-NITROBENZO-ORTHO-TOLUIDIDE ... AS HUMAN URINARY METABOLITE.
Testa, B. and P. Jenner. Drug Metabolism: Chemical & Biochemical Aspects. New York: Marcel Dekker, Inc., 1976., p. 72
BIOTRANSFORMATION ... WOULD BE EXPECTED TO PROCEED BY HYDROXYLATION, & THIS LARGELY OCCURS IN PRACTICE, WHEN GLUCURONIDES OF ... 2-METHYL-3-(3-HYDROXY-2-METHYLPHENYL)-4(3H)-QUINAZOLINONE, 2-METHYL-3-O-TOLYL-6-HYDROXY-4(3H)-QUINAZOLINONE & 2-METHYL-3-O-TOLYL-8-HYDROXY-4(3H)-QUINAZOLINONE ... EXCRETED IN URINE OF ... RATS.
The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 1: A Review of the Literature Published Between 1960 and 1969. London: The Chemical Society, 1970., p. 156
For more Metabolism/Metabolites (Complete) data for METHAQUALONE (7 total), please visit the HSDB record page.
Methaqualone has known human metabolites that include hydroxy-methaqualone.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
2-3 hr /From table/
Amdur, M.O., J. Doull, C.D. Klaasen (eds). Casarett and Doull's Toxicology. 4th ed. New York, NY: Pergamon Press, 1991., p. 942
IN ADDITION TO SEDATIVE-HYPNOTIC PROPERTIES ... /IT/ POSSESSES ANTICONVULSANT, ANTISPASMODIC, LOCAL ANESTHETIC, & WEAK ANTIHISTAMINIC PROPERTIES. IN HIGH DOSES IT SELECTIVELY DEPRESSES POLYSYNAPTIC PATHWAYS IN THE SPINAL CORD. THE DRUG HAS ANTITUSSIVE ACTIVITY COMPARABLE TO THAT OF CODEINE ... IT LACKS ANALGESIC ACTIVITY.
Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 367
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