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1. 4-(alpha-(p-(diethylamino)phenyl)-(2,5-disulfobenzylidene)-2,5-cyclohexadien-1-ylidene)diethylammonium Hydroxide Inner Salt, Sodium Salt
2. Iso-sulfan Blue
3. Iso-sulphan Blue
4. Lymphazurin
5. Lymphazurin Blue
1. 68238-36-8
2. Sulphan Blue
3. Isosulfan Blue [usan]
4. Iso-sulfan Blue
5. Patentblueviolet
6. Sulphan Blue 2,5-disulfophenyl Isomer
7. Lymphazurin
8. Sodium 2-((4-(diethylamino)phenyl)(4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene)methyl)benzene-1,4-disulfonate
9. P-1888
10. P-4125
11. 39n9k8s2a4
12. Mfcd00867653
13. Nsc-734902
14. Ethanaminium, N-(4-((4-(diethylamino)phenyl)(2,5-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-n-ethyl-, Hydroxide, Inner Salt, Sodium Salt
15. Sulfanblau
16. Isosulfan Blue (usan)
17. Disulphin Blau
18. Patent Blau V
19. Azul Isosulfano
20. Bleu Isosulfan
21. Blu Isosulfan
22. Unii-39n9k8s2a4
23. Hsdb 8071
24. Azul De Isosulfan
25. P 1888
26. P 4125
27. Lymphazurin (tn)
28. Dsstox_cid_31594
29. Dsstox_rid_97478
30. Dsstox_gsid_57805
31. (4-(alpha-(p-(diethylamino)phenyl)-2,5-disulfobenzylidene)-2,5-cyclohexadien-1-ylidene)diethylammonium Hydroxide, Inner Salt, Sodium Salt
32. Isosulfan Blue [vandf]
33. Schembl3324345
34. Chembl1200859
35. Dtxsid8057805
36. Isosulfan Blue [who-dd]
37. Tox21_113733
38. Isosulfan Blue [orange Book]
39. Akos015904521
40. Fd10698
41. Nsc 734902
42. Ncgc00253597-01
43. Sy238240
44. Cas-68238-36-8
45. D04634
46. Sulphan Blue 2,5-disulfophenyl Isomer [mi]
47. (4-(.alpha.-(p-(diethylamino)phenyl)-2,5-disulfobenzylidene)-2,5-cyclohexadien-1-ylidene)diethylammonium Hydroxide, Inner Salt, Sodium Salt
48. Ethanaminium, N-(4-((4-(diethylamino)phenyl)(2,5-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-n-ethyl-, Inner Salt, Sodium Salt
49. Sodium 2-((4-(diethylamino)phenyl)(4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene)methyl)benzene-1,4-disulphonate
50. Sodium;2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,4-disulfonate
| Molecular Weight | 566.7 g/mol |
|---|---|
| Molecular Formula | C27H31N2NaO6S2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 7 |
| Exact Mass | 566.15212334 g/mol |
| Monoisotopic Mass | 566.15212334 g/mol |
| Topological Polar Surface Area | 137 Ų |
| Heavy Atom Count | 38 |
| Formal Charge | 0 |
| Complexity | 1040 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
| 1 of 2 | |
|---|---|
| Drug Name | Isosulfan blue |
| PubMed Health | Isosulfan Blue (Injection) |
| Drug Classes | Diagnostic Agent, Lymphatic Visualization |
| Drug Label | The chemical name of isosulfan blue injection 1% is N-[4- [[4-(diethylamino)phenyl] (2,5-disulfophenyl) methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium hydroxide, inner salt, sodium salt. Its structural formula is:ISOSULFAN BLUEIsosulfan... |
| Active Ingredient | Isosulfan blue |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 1% |
| Market Status | Prescription |
| Company | Mylan Institutional |
| 2 of 2 | |
|---|---|
| Drug Name | Isosulfan blue |
| PubMed Health | Isosulfan Blue (Injection) |
| Drug Classes | Diagnostic Agent, Lymphatic Visualization |
| Drug Label | The chemical name of isosulfan blue injection 1% is N-[4- [[4-(diethylamino)phenyl] (2,5-disulfophenyl) methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium hydroxide, inner salt, sodium salt. Its structural formula is:ISOSULFAN BLUEIsosulfan... |
| Active Ingredient | Isosulfan blue |
| Dosage Form | Injectable |
| Route | Injection |
| Strength | 1% |
| Market Status | Prescription |
| Company | Mylan Institutional |
Isosulfan blue injection 1% upon subcutaneous administration, delineates lymphatic vessels draining the region of injection. It is an adjunct to lymphography in: primary and secondary lymphedema of the extremities; chyluria, chylous ascites or chylothorax; lymph node involvement by primary or secondary neoplasm; and lymph node response to therapeutic modalities. /Included in US product label/
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
Isosulfan blue injection 1% is contraindicated in those individuals with known hypersensitivity to triphenylmethane or related compounds.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
Life-threatening anaphylactic reactions (respiratory distress, shock, angioedema) have occurred after isosulfan blue injection 1% administration. Reactions are more likely to occur in patients with a history of bronchial asthma, allergies, drug reactions or previous reactions to triphenylmethane dyes. Monitor patients closely for at least 60 minutes after administration of isosulfan blue injection 1%. Trained personnel should be available to administer emergency care including resuscitation.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
Isosulfan blue injection 1% interferes with measurements of oxygen saturation in peripheral blood by pulse oximetry and can cause falsely low readings. The interference effect is maximal at 30 minutes and minimal generally by four hours after administration. Arterial blood gas analysis may be needed to verify decreased arterial partial pressure of oxygen.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
Isosulfan blue injection 1% may also cause falsely elevated readings of methemoglobin by arterial blood gas analyzer. Therefore, co-oximetry may be needed to verify methemoglobin level.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
For more Drug Warnings (Complete) data for Isosulfan blue (10 total), please visit the HSDB record page.
Coloring Agents
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)
Following subcutaneous administration, isosulfan blue injection 1% binds to serum proteins and is picked up by the lymphatic vessels. Thus, the lymphatic vessels are delineated by the blue dye.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
It is not known whether this drug is excreted in human milk.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
Up to 10% of the subcutaneously administered dose of isosulfan blue injection 1% is excreted unchanged in the urine in 24 hours in humans.
US Natl Inst Health; DailyMed. Current Medication Information for ISOSULFAN BLUE injection, solution (August 2010). Available from, as of June 8, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1878964e-5220-48c8-a872-dcadbc451aff
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