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DSSTox_CID_3078

Synopsis, Chemistry

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Also known as: 63585-09-1, Foscavir, Trisodium phosphonoformate, Triapten, Trisodium carboxyphosphate, Foscarnet sodique

Molecular Formula

CNa₃O₅P

Molecular Weight

191.95 g/mol

InChI Key

DFHAXXVZCFXGOQ-UHFFFAOYSA-K

FDA UNII

8C5OQ81LWT

An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.

1 2D Structure

DSSTox_CID_3078

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

trisodium;phosphonatoformate

2.1.2 InChI

InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6;;;/h(H,2,3)(H2,4,5,6);;;/q;3*+1/p-3

2.1.3 InChI Key

DFHAXXVZCFXGOQ-UHFFFAOYSA-K

2.1.4 Canonical SMILES

C(=O)([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

8C5OQ81LWT

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Foscarnet

2. Foscarnet Barium (2:3) Salt

3. Foscarnet Calcium (2:3) Salt

4. Foscarnet Disodium Salt

5. Foscarnet Magnesium (2:3) Salt

6. Foscarnet Manganese (2+) (2:3) Salt

7. Foscarnet Sodium Hexahydrate

8. Foscarnet Trilithium Salt

9. Foscarnet Tripotassium Salt

10. Foscarnet Trisodium Salt

11. Foscavir

12. Phosphonoformate

13. Phosphonoformic Acid

14. Trisodium Phosphonoformate

2.3.2 Depositor-Supplied Synonyms

1. 63585-09-1

2. Foscavir

3. Trisodium Phosphonoformate

4. Triapten

5. Trisodium Carboxyphosphate

6. Foscarnet Sodique

7. Foscarneto Sodico

8. Foscarnetum Natricum

9. Foscarnet Trisodium

10. Phosphonoformate

11. Phosphonoformic Acid, Trisodium Salt

12. Foscarnetsodium

13. Ehb 776

14. Trisodium;phosphonatoformate

15. Sodium Phosphonatoformate

16. Foscarnet (sodium)

17. Foscavir (tn)

18. Foscarnet Sodium Anhydrous

19. Phosphinecarboxylic Acid, Dihydroxy-, Oxide, Trisodium Salt

20. A-29622

21. 8c5oq81lwt

22. Ehb-776

23. Foscarnet Sodium Hydrate

24. Chebi:141644

25. Nsc-313410

26. Nsc-758148

27. Ncgc00094941-01

28. Foscarnet Sodico

29. Dsstox_cid_3078

30. Dsstox_rid_76865

31. Dsstox_gsid_23078

32. Trisodium Dioxidophosphinecarboxylate Oxide

33. Foscarnet Sodico [spanish]

34. Foscarnet Sodique [french]

35. Foscarnetum Natricum [latin]

36. Chembl754

37. Trisodium Phosphonoformate;phosphonoformic Acid Trisodium Salt

38. Virudin

39. Gefin

40. Foscarnet Sodique [inn-french]

41. Foscarneto Sodico [inn-spanish]

42. Foscarnetum Natricum [inn-latin]

43. Drg-0017

44. Cas-63585-09-1

45. A 29622

46. Unii-8c5oq81lwt

47. Dihydroxyphosphinecarboxylic Acid Oxide Trisodium Salt

48. Phosphonoformic Acid Trisodium Salt

49. Trisodium Carboxyphosphate (anhydrous)

50. Trisodium Phosphonoformate (anhydrous)

51. Foscarnet Sodium [usan:usp:inn:ban]

52. Trisodium Dioxidophosphanecarboxylate Oxide

53. Foscarnet Sodium (usp/inn)

54. Foscarnet Sodium [mi]

55. Spectrum1502019

56. Foscarnet Sodium [inn]

57. Foscarnet Sodium Assay Standard

58. Dtxsid6023078

59. Hms502n17

60. Foscarnet Sodium [who-dd]

61. Hms1921d18

62. Hms2092n15

63. Hms3651j20

64. Bcp14044

65. Tox21_111364

66. Ccg-40026

67. S3076

68. Akos003599741

69. Akos015951387

70. Tox21_111364_1

71. Ac-2085

72. Ks-1418

73. Nsc 313410

74. Nsc 758148

75. Ncgc00094941-02

76. Ncgc00178317-03

77. Ac-19808

78. Db-054506

79. Ft-0626544

80. Sw220295-1

81. D00579

82. D78325

83. Q27225687

84. Phosphinecarboxylic Acid, 1,1-dihydroxy-, 1-oxide, Sodium Salt (1:3)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	CNa₃O₅P
Molecular Weight	191.95 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	0
Exact Mass	191.91764294 g/mol
Monoisotopic Mass	191.91764294 g/mol
Topological Polar Surface Area	103 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	103
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Foscarnet sodium
PubMed Health	Foscarnet (Injection)
Drug Classes	Antiviral
Drug Label	FOSCAVIR is the brand name for foscarnet sodium. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula o...
Active Ingredient	Foscarnet sodium
Dosage Form	Injectable
Route	Injection
Strength	2.4gm/100ml
Market Status	Prescription
Company	Hospira

2 of 4
Drug Name	Foscavir
Drug Label	FOSCAVIR is the brand name for foscarnet sodium. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula o...
Active Ingredient	Foscarnet sodium
Dosage Form	Injectable
Route	Injection
Strength	2.4gm/100ml
Market Status	Prescription
Company	Clinigen Hlthcare

3 of 4
Drug Name	Foscarnet sodium
PubMed Health	Foscarnet (Injection)
Drug Classes	Antiviral
Drug Label	FOSCAVIR is the brand name for foscarnet sodium. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula o...
Active Ingredient	Foscarnet sodium
Dosage Form	Injectable
Route	Injection
Strength	2.4gm/100ml
Market Status	Prescription
Company	Hospira

4 of 4
Drug Name	Foscavir
Drug Label	FOSCAVIR is the brand name for foscarnet sodium. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula o...
Active Ingredient	Foscarnet sodium
Dosage Form	Injectable
Route	Injection
Strength	2.4gm/100ml
Market Status	Prescription
Company	Clinigen Hlthcare

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Reverse Transcriptase Inhibitors

Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

DNA Polymerase Inhibitors [MoA]; Pyrophosphate Analog DNA Polymerase Inhibitor [EPC]; Pyrophosphate Analog [EXT]; Chelating Activity [MoA]