DSSTox_CID_3005

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

3 API Suppliers, 2 USDMF, 2 NDC API

DOSSIERs // Finished Dosage Formulations

24 Dossiers, 20 FDA Orange Book, 1 South Africa, 3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 6 Roquette, 5 Microlex e.U, 4 Kerry, 3 SPI Pharma, 2 Gangwal Healthcare, 2 Ingredion Pharma Solutions, 2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 BASF, 1 Prachin Chemical, 1 Seppic, 1 Sigachi Industries, 1 DKSH, 1 Gangwal Chemicals, 1 Vasa Pharmachem, 1 Aeon Procare

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 10 Lubricants & Glidants, 8 Direct Compression, 5 Co-Processed Excipients, 4 Disintegrants & Superdisintegrants, 4 Controlled & Modified Release, 3 Chewable & Orodispersible Aids, 3 Taste Masking, 3 Coating Systems & Additives, 3 Granulation, 2 Thickeners and Stabilizers, 1 Emulsifying Agents, 1 Film Formers & Plasticizers

GLOBAL SALES INFORMATION

6 US Medicaid Prescriptions, 1 Finished Drug Prices

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 Other Ref. Standards

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Also known as: 7280-37-7, Piperazine estrone sulfate, Ogen, Harmogen, Ortho-est, Estrone sulfate piperazine salt

Molecular Formula

C₂₂H₃₂N₂O₅S

Molecular Weight

436.6 g/mol

InChI Key

HZEQBCVBILBTEP-ZFINNJDLSA-N

FDA UNII

SVI38UY019

Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine. Estropipate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics.

1 2D Structure

DSSTox_CID_3005

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate;piperazine

2.1.2 InChI

InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1

2.1.3 InChI Key

HZEQBCVBILBTEP-ZFINNJDLSA-N

2.1.4 Canonical SMILES

CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1

2.1.5 Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1

2.2 Other Identifiers

2.2.1 UNII

SVI38UY019

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, Compd. With Piperazine (1:1)

2. Genoral

3. Harmogen

4. Harmonet

5. Ogen

6. Ortho-est

7. Piperazine Estrone Sulfate

2.3.2 Depositor-Supplied Synonyms

1. 7280-37-7

2. Piperazine Estrone Sulfate

3. Ogen

4. Harmogen

5. Ortho-est

6. Estrone Sulfate Piperazine Salt

7. Sulestrex Piperazine

8. Piperazine Estrone Sulphate

9. Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, Compd. With Piperazine (1:1)

10. Svi38uy019

11. Piperazine Estronesulfate

12. Nsc-758912

13. Estrone Hydrogen Sulfate Compound With Piperazine (1:1)

14. Sulestrex

15. Unii-svi38uy019

16. Piperazine (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthren-3-yl Sulfate

17. Ogen 5

18. Pipestrone

19. Estropipate [usp:inn:ban]

20. Ogen 2.5

21. Ogen .625

22. Ogen 1.25

23. Einecs 230-696-3

24. Estropipate (usp)

25. Ogen (tn)

26. Piperazineestronesulfate

27. Ncgc00016682-02

28. Dsstox_cid_3005

29. Cas-7280-37-7

30. Estropipate [vandf]

31. Piperazine Oestrone Sulphate

32. Conjugated Estrogens: Piperazine Estrone Sulfate

33. Dsstox_rid_76828

34. Estropipate [mart.]

35. Dsstox_gsid_23005

36. Schembl21577

37. Estropipate [usp-rs]

38. Estropipate [who-dd]

39. Mls002153957

40. Chebi:4873

41. Chembl1200980

42. Dtxsid3023005

43. Piperazine, Compd. With Estrone Hydrogen Sulfate (1:1)

44. Estrone, Hydrogen Sulfate, Compd. With Piperazine (1:1)

45. Estropipate [orange Book]

46. Hms1570i17

47. Hms2097i17

48. Hms2232o19

49. Hms3714i17

50. Estropipate [usp Monograph]

51. Bcp05424

52. Hy-b1361

53. Tox21_113350

54. S5288

55. Akos024457702

56. Estra-1,3,5(10)-trien-17-one 3-sulphate, Compound With Piperazine (1:1)

57. Piperazine, Compd. With 3-(sulfooxy)estra-1,3,5(10)-trien-17-one (1:1)

58. Bcp9000662

59. Ccg-220688

60. Cs-4818

61. Estropipate, >=98% (hplc), Powder

62. Nsc 758912

63. [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate,piperazine

64. Smr001233296

65. Am20080957

66. Estrone Sulfate Piperazine Salt [mi]

67. D00948

68. 280e377

69. A837628

70. Sr-01000000235

71. Q5401860

72. Sr-01000000235-5

73. Estrone Hydrogen Sulphate Compound With Piperazine (1:1)

74. Estropipate, United States Pharmacopeia (usp) Reference Standard

75. 17-oxoestra-1,3,5(10)-trien-3-yl Hydrogen Sulfate - Piperazine (1:1)

76. [(8r,9s,13s,14s)-13-methyl-17-oxidanylidene-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate; Piperazine

77. [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate;piperazine

78. Piperazine; Sulfuric Acid [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Ester

2.4 Create Date

2005-11-20

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₃₂N₂O₅S
Molecular Weight	436.6 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	436.20319330 g/mol
Monoisotopic Mass	436.20319330 g/mol
Topological Polar Surface Area	113 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	650
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 10
Drug Name	Estropipate
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	1.5mg; 3mg; 0.75mg
Market Status	Prescription
Company	Watson Labs; Mylan; Barr

2 of 10
Drug Name	Ogen .625
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	0.75mg
Market Status	Prescription
Company	Pharmacia And Upjohn

3 of 10
Drug Name	Ogen 1.25
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	1.5mg
Market Status	Prescription
Company	Pharmacia And Upjohn

4 of 10
Drug Name	Ogen 2.5
PubMed Health	Estropipate
Drug Classes	Endocrine-Metabolic Agent, Female Reproductive Agent, Musculoskeletal Agent
Drug Label	Estropipate (formerly piperazine estrone sulfate), is a natural estrogenic substance prepared from purified crystalline estrone, solubilized as the sulfate and stabilized with piperazine. It is appreciably soluble in water and has almost no odor or t...
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	3mg
Market Status	Prescription
Company	Pharmacia And Upjohn

5 of 10
Drug Name	Ogen 5
PubMed Health	Estrogen
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	6mg
Market Status	Prescription
Company	Pharmacia And Upjohn

6 of 10
Drug Name	Estropipate
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	1.5mg; 3mg; 0.75mg
Market Status	Prescription
Company	Watson Labs; Mylan; Barr

7 of 10
Drug Name	Ogen .625
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	0.75mg
Market Status	Prescription
Company	Pharmacia And Upjohn

8 of 10
Drug Name	Ogen 1.25
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	1.5mg
Market Status	Prescription
Company	Pharmacia And Upjohn

9 of 10
Drug Name	Ogen 2.5
PubMed Health	Estropipate
Drug Classes	Endocrine-Metabolic Agent, Female Reproductive Agent, Musculoskeletal Agent
Drug Label	Estropipate (formerly piperazine estrone sulfate), is a natural estrogenic substance prepared from purified crystalline estrone, solubilized as the sulfate and stabilized with piperazine. It is appreciably soluble in water and has almost no odor or t...
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	3mg
Market Status	Prescription
Company	Pharmacia And Upjohn

10 of 10
Drug Name	Ogen 5
PubMed Health	Estrogen
Active Ingredient	Estropipate
Dosage Form	Tablet
Route	Oral
Strength	6mg
Market Status	Prescription
Company	Pharmacia And Upjohn

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Contraceptive Agents, Hormonal

Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)

Find Estropipate manufacturers, exporters & distributors on PharmaCompass

DSSTox_CID_3005

DSSTox_CID_3005

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

3 API Suppliers

2 USDMF

2 NDC API

DOSSIERs // Finished Dosage Formulations

24 Dossiers

20 FDA Orange Book

1 South Africa

3 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers

6 Roquette

5 Microlex e.U

4 Kerry

3 SPI Pharma

2 Gangwal Healthcare

2 Ingredion Pharma Solutions

2 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

2 BASF

1 Prachin Chemical

1 Seppic

1 Sigachi Industries

1 DKSH

1 Gangwal Chemicals

1 Vasa Pharmachem

1 Aeon Procare

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders

10 Lubricants & Glidants

8 Direct Compression

5 Co-Processed Excipients

4 Disintegrants & Superdisintegrants

4 Controlled & Modified Release

3 Chewable & Orodispersible Aids

3 Taste Masking

3 Coating Systems & Additives

3 Granulation

2 Thickeners and Stabilizers

1 Emulsifying Agents

1 Film Formers & Plasticizers

GLOBAL SALES INFORMATION

6 US Medicaid Prescriptions

1 Finished Drug Prices

ANALYTICAL SOLUTION(s)

1 USP Standards

1 Other Ref. Standards

API SUPPLIERS

API REF. PRICE (USD / KG)

INTERMEDIATES

DOSSIERS // FDF

GLOBAL SALES (USD Million)

EXCIPIENTS

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

REF STANDARD

SERVICES

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