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1. 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl)-1-piperidinyl)ethyl)-2-imidazolidinone
2. Lu 23-174
3. Lu-23-174
4. Serdolect
5. Serlect
6. Sertindole Hydrochloride
1. 106516-24-9
2. Serlect
3. Serdolect
4. Sertindol
5. Lu 23-174
6. Sertindolum
7. Sertindol [inn-spanish]
8. Sertindolum [inn-latin]
9. Zerdol
10. Lu-23-174
11. 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
12. 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
13. Gvv4z879sp
14. Chembl12713
15. Chebi:9122
16. 1-(2-(4-(5-chloro-1-(p-fluorophenyl)indol-3-yl)piperidino)ethyl)-2-imidazolidinone
17. 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one
18. Ncgc00181782-01
19. Ncgc00181782-02
20. 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl)piperidin-1-yl)ethyl)imidazolidin-2-one
21. 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
22. 2-imidazolidinone, 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl)-1-piperidinyl)ethyl)-
23. Dsstox_cid_28893
24. Dsstox_rid_83161
25. Dsstox_gsid_48967
26. 1-(2-{4-[5-chloro-1-(p-fluorophenyl)indol-3-yl]piperidino}ethyl)-2-imidazolidinone
27. 2-imidazolidinone, 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-
28. Serlect (tn)
29. Cas-106516-24-9
30. Sertindole (usan/inn)
31. Unii-gvv4z879sp
32. Sertindole [usan:inn:ban]
33. 1-(2-(4-[5-chloro-1-(4-fluoro-phenyl)-1h-indol-3-yl]-piperidin-1-yl)-ethyl)-imidazolidin-2-one
34. 1-(2-{4-[5-chloro-1-(4-fluoro-phenyl)-1h-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one
35. 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl}ethyl)-2-imidazolidinone
36. Mfcd00867749
37. 1-(2-(4-(5-chloro-1-(4-fluorophenyl)-1h-indole-3-yl)-1-piperidinyl)ethyl)-2-imidazolidinone
38. Sertindole [mi]
39. Sertindole [inn]
40. Sertindole [usan]
41. Sertindole [vandf]
42. Gtpl98
43. S-1991
44. Sertindole [mart.]
45. Sertindole [who-dd]
46. Mls003899237
47. Schembl112092
48. Dtxsid6048967
49. Ex-a883
50. Hms3713p22
51. Zinc538337
52. Bcp27121
53. Sertindole, >=97.5% (hplc)
54. Tox21_113408
55. Tox21_113421
56. Bdbm50001786
57. Pdsp1_001561
58. Pdsp2_001545
59. Akos015962616
60. Tox21_113421_1
61. Ccg-220640
62. Db06144
63. 5-chloro-1-(4-fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidyl]-1h-indole
64. Ncgc00181782-03
65. Ac-32937
66. As-56243
67. Hy-14543
68. Smr002204118
69. Ft-0674562
70. S0942
71. C07567
72. D00561
73. L001396
74. Q418050
75. Sr-01000872708
76. J-001604
77. Sr-01000872708-1
78. 5-chloro-1-(4'-fluorophenyl)-3-(1-(2-(2imidazolidinon-1-yl)ethyl)-4-piperidyl)-1h-indole
79. 5-chloro-1-(4'-fluorophenyl)-3-(1-(2-imidazolidinon-1-ylethyl)-4-piperidyl)-1h-indole
Molecular Weight | 440.9 g/mol |
---|---|
Molecular Formula | C24H26ClFN4O |
XLogP3 | 4.1 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 3 |
Rotatable Bond Count | 5 |
Exact Mass | 440.1779173 g/mol |
Monoisotopic Mass | 440.1779173 g/mol |
Topological Polar Surface Area | 40.5 Ų |
Heavy Atom Count | 31 |
Formal Charge | 0 |
Complexity | 623 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Used in the treatment of schizophrenia.
Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia. Sertindole is generally well tolerated and is associated with a low rate of extrapyramidal symptoms (EPS).
Antipsychotic Agents
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)
N - Nervous system
N05 - Psycholeptics
N05A - Antipsychotics
N05AE - Indole derivatives
N05AE03 - Sertindole
Absorption
Orally available.
Hepatic. Sertindole is metabolized by cytochrome P450 isoenzymes CYP 2D6 and CYP 3A4.
Sertindole has known human metabolites that include 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]-4-hydroxyimidazolidin-2-one and 5-Chloro-1-(4-fluorophenyl)-3-(piperidin-4-yl)-1H-indole.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
3 days
Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.
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A DSSTox_CID_28893 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of DSSTox_CID_28893, including repackagers and relabelers. The FDA regulates DSSTox_CID_28893 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. DSSTox_CID_28893 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A DSSTox_CID_28893 supplier is an individual or a company that provides DSSTox_CID_28893 active pharmaceutical ingredient (API) or DSSTox_CID_28893 finished formulations upon request. The DSSTox_CID_28893 suppliers may include DSSTox_CID_28893 API manufacturers, exporters, distributors and traders.
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A DSSTox_CID_28893 DMF (Drug Master File) is a document detailing the whole manufacturing process of DSSTox_CID_28893 active pharmaceutical ingredient (API) in detail. Different forms of DSSTox_CID_28893 DMFs exist exist since differing nations have different regulations, such as DSSTox_CID_28893 USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A DSSTox_CID_28893 DMF submitted to regulatory agencies in the US is known as a USDMF. DSSTox_CID_28893 USDMF includes data on DSSTox_CID_28893's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The DSSTox_CID_28893 USDMF is kept confidential to protect the manufacturer’s intellectual property.
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DSSTox_CID_28893 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of DSSTox_CID_28893 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right DSSTox_CID_28893 GMP manufacturer or DSSTox_CID_28893 GMP API supplier for your needs.
A DSSTox_CID_28893 CoA (Certificate of Analysis) is a formal document that attests to DSSTox_CID_28893's compliance with DSSTox_CID_28893 specifications and serves as a tool for batch-level quality control.
DSSTox_CID_28893 CoA mostly includes findings from lab analyses of a specific batch. For each DSSTox_CID_28893 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
DSSTox_CID_28893 may be tested according to a variety of international standards, such as European Pharmacopoeia (DSSTox_CID_28893 EP), DSSTox_CID_28893 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (DSSTox_CID_28893 USP).