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Also known as: 83898-65-1, 99497-03-7, 899u5wf46a, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one maleate, (z)-but-2-enedioic acid;6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1h-benzimidazol-2-one, Prestwick-06g02
Molecular Formula
C26H28ClN5O6
Molecular Weight
542.0  g/mol
InChI Key
OAUUYDZHCOULIO-BTJKTKAUSA-N
FDA UNII
899U5WF46A

Domperidone Maleate
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
1 2D Structure

Domperidone Maleate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
2.1.2 InChI
InChI=1S/C22H24ClN5O2.C4H4O4/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29;5-3(6)1-2-4(7)8/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30);1-2H,(H,5,6)(H,7,8)/b;2-1-
2.1.3 InChI Key
OAUUYDZHCOULIO-BTJKTKAUSA-N
2.1.4 Canonical SMILES
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
899U5WF46A
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apo Domperidone

2. Apo-domperidone

3. Domidon

4. Domperidon

5. Domperidon Al

6. Domperidon Hexal

7. Domperidon Stada

8. Domperidon Teva

9. Domperidon-teva

10. Domperidona Gamir

11. Domperidone

12. Domperidone Maleate (1:1)

13. Domperidone Monohydrochloride

14. Gamir, Domperidona

15. Gastrocure

16. Hexal, Domperidon

17. Maleate, Domperidone

18. Monohydrochloride, Domperidone

19. Motilium

20. Nauzelin

21. Novo Domperidone

22. Novo-domperidone

23. Nu Domperidone

24. Nu-domperidone

25. Pridys

26. Pms Domperidone

27. Pms-domperidone

28. R-33,812

29. R-33812

30. R33,812

31. R33812

32. Ratio Domperidone

33. Ratio-domperidone

34. Stada, Domperidon

2.3.2 Depositor-Supplied Synonyms

1. 83898-65-1

2. 99497-03-7

3. 899u5wf46a

4. 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one Maleate

5. (z)-but-2-enedioic Acid;6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1h-benzimidazol-2-one

6. Prestwick-06g02

7. Chebi:59812

8. 2h-benzimidazol-2-one,5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-, (2z)-2-butenedioate

9. 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2h-benzimidazol-2-one Maleate

10. Unii-899u5wf46a

11. Domperidone (tn)

12. Einecs 281-277-7

13. Schembl447643

14. Chembl3436365

15. Domperidone (as Maleate)

16. Hy-b0411a

17. Dtxsid901019221

18. Domperidone Maleate [mart.]

19. Zda49703

20. Domperidone Maleate [who-dd]

21. Mfcd07370074

22. Akos025312518

23. Ncgc00017157-01

24. 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one Maleate

25. Domperidone Maleate [ep Monograph]

26. Cs-0013583

27. D07868

28. 497d037

29. Q27126907

30. 5-chloro-1-(1-(3-(2-oxobenzimidazolin-1-yl)propyl)-4-piperidyl)benzimidazolin-2-one Maleate

2.4 Create Date
2006-05-30
3 Chemical and Physical Properties
Molecular Weight 542.0 g/mol
Molecular Formula C26H28ClN5O6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass541.1728113 g/mol
Monoisotopic Mass541.1728113 g/mol
Topological Polar Surface Area143 Ų
Heavy Atom Count38
Formal Charge0
Complexity774
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


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07-Jan-2021
31-Mar-2025
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ABOUT THIS PAGE

Looking for 83898-65-1 / Domperidone Maleate API manufacturers, exporters & distributors?

Domperidone Maleate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Domperidone Maleate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Domperidone Maleate manufacturer or Domperidone Maleate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Domperidone Maleate manufacturer or Domperidone Maleate supplier.

PharmaCompass also assists you with knowing the Domperidone Maleate API Price utilized in the formulation of products. Domperidone Maleate API Price is not always fixed or binding as the Domperidone Maleate Price is obtained through a variety of data sources. The Domperidone Maleate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Domperidone Maleate

Synonyms

83898-65-1, 99497-03-7, 899u5wf46a, 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2h-benzimidazol-2-one maleate, (z)-but-2-enedioic acid;6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1h-benzimidazol-2-one, Prestwick-06g02

Cas Number

83898-65-1

Unique Ingredient Identifier (UNII)

899U5WF46A

About Domperidone Maleate

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Domperidone Maleate Manufacturers

A Domperidone Maleate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Domperidone Maleate, including repackagers and relabelers. The FDA regulates Domperidone Maleate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Domperidone Maleate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Domperidone Maleate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Domperidone Maleate Suppliers

A Domperidone Maleate supplier is an individual or a company that provides Domperidone Maleate active pharmaceutical ingredient (API) or Domperidone Maleate finished formulations upon request. The Domperidone Maleate suppliers may include Domperidone Maleate API manufacturers, exporters, distributors and traders.

click here to find a list of Domperidone Maleate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Domperidone Maleate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Domperidone Maleate Drug Master File in Korea (Domperidone Maleate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Domperidone Maleate. The MFDS reviews the Domperidone Maleate KDMF as part of the drug registration process and uses the information provided in the Domperidone Maleate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Domperidone Maleate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Domperidone Maleate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Domperidone Maleate suppliers with KDMF on PharmaCompass.

Domperidone Maleate CEP

A Domperidone Maleate CEP of the European Pharmacopoeia monograph is often referred to as a Domperidone Maleate Certificate of Suitability (COS). The purpose of a Domperidone Maleate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Domperidone Maleate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Domperidone Maleate to their clients by showing that a Domperidone Maleate CEP has been issued for it. The manufacturer submits a Domperidone Maleate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Domperidone Maleate CEP holder for the record. Additionally, the data presented in the Domperidone Maleate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Domperidone Maleate DMF.

A Domperidone Maleate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Domperidone Maleate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Domperidone Maleate suppliers with CEP (COS) on PharmaCompass.

Domperidone Maleate WC

A Domperidone Maleate written confirmation (Domperidone Maleate WC) is an official document issued by a regulatory agency to a Domperidone Maleate manufacturer, verifying that the manufacturing facility of a Domperidone Maleate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Domperidone Maleate APIs or Domperidone Maleate finished pharmaceutical products to another nation, regulatory agencies frequently require a Domperidone Maleate WC (written confirmation) as part of the regulatory process.

click here to find a list of Domperidone Maleate suppliers with Written Confirmation (WC) on PharmaCompass.

Domperidone Maleate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Domperidone Maleate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Domperidone Maleate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Domperidone Maleate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Domperidone Maleate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Domperidone Maleate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Domperidone Maleate suppliers with NDC on PharmaCompass.

Domperidone Maleate GMP

Domperidone Maleate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Domperidone Maleate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Domperidone Maleate GMP manufacturer or Domperidone Maleate GMP API supplier for your needs.

Domperidone Maleate CoA

A Domperidone Maleate CoA (Certificate of Analysis) is a formal document that attests to Domperidone Maleate's compliance with Domperidone Maleate specifications and serves as a tool for batch-level quality control.

Domperidone Maleate CoA mostly includes findings from lab analyses of a specific batch. For each Domperidone Maleate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Domperidone Maleate may be tested according to a variety of international standards, such as European Pharmacopoeia (Domperidone Maleate EP), Domperidone Maleate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Domperidone Maleate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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