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ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Slentrol, 481658-94-0, Chembl410414, Cp-742,033, 578h0rmp25, Cp-742033
Molecular Formula
C40H33F3N4O3
Molecular Weight
674.7  g/mol
InChI Key
TUOSYWCFRFNJBS-BHVANESWSA-N
FDA UNII
578H0RMP25

Dirlotapide
Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human use.
1 2D Structure

Dirlotapide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide
2.1.2 InChI
InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1
2.1.3 InChI Key
TUOSYWCFRFNJBS-BHVANESWSA-N
2.1.4 Canonical SMILES
CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)NC(C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
2.1.5 Isomeric SMILES
CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)N[C@@H](C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
2.2 Other Identifiers
2.2.1 UNII
578H0RMP25
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1h-indole-2-carboxylic Acid Benzylmethyl Carbamoylamide

2.3.2 Depositor-Supplied Synonyms

1. Slentrol

2. 481658-94-0

3. Chembl410414

4. Cp-742,033

5. 578h0rmp25

6. Cp-742033

7. (s)-n-(2-(benzyl(methyl)amino)-2-oxo-1-phenylethyl)-1-methyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)-1h-indole-2-carboxamide

8. 1h-indole-2-carboxamide, 1-methyl-n-((1s)-2-(methyl(phenylmethyl)amino)-2-oxo-1-phenylethyl)-5-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-

9. N-((1s)-2-(benzylmethylamino)-2-oxo-1-phenylethyl)-1-methyl-5-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)-1h-indole-2-carboxamide

10. Dirlotapide [usan:inn]

11. Unii-578h0rmp25

12. Cp 742033

13. Dirlotapide [mi]

14. Dirlotapide [inn]

15. Dirlotapide (usan/inn)

16. Dirlotapide [usan]

17. Schembl37781

18. Slentrol [veterinary] (tn)

19. Dirlotapide [green Book]

20. Dtxsid00897432

21. Bdbm50204367

22. Hy-u00070

23. Cs-6779

24. Db11399

25. Dirlotapide [ema Epar Veterinary]

26. D03867

27. Q5280905

28. (s)-n-{2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1h-indole-2-carboxamide

29. 5-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1h-indole-2-carboxylic Acid Benzylmethyl Carbamoylamide

30. N-[(1s)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 674.7 g/mol
Molecular Formula C40H33F3N4O3
XLogP37.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass674.25047541 g/mol
Monoisotopic Mass674.25047541 g/mol
Topological Polar Surface Area83.4 Ų
Heavy Atom Count50
Formal Charge0
Complexity1150
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

As an aid in the management of overweight and obesity in adult dogs. To be used as part of an overall weight-management programme that also includes appropriate dietary changes and exercise practice.


5 Pharmacology and Biochemistry
5.1 ATC Code

QA08AB91


Patents & EXCLUSIVITIES

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ABOUT THIS PAGE

Looking for 481658-94-0 / Dirlotapide API manufacturers, exporters & distributors?

Dirlotapide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Dirlotapide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Dirlotapide manufacturer or Dirlotapide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Dirlotapide manufacturer or Dirlotapide supplier.

PharmaCompass also assists you with knowing the Dirlotapide API Price utilized in the formulation of products. Dirlotapide API Price is not always fixed or binding as the Dirlotapide Price is obtained through a variety of data sources. The Dirlotapide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Dirlotapide

Synonyms

Slentrol, 481658-94-0, Chembl410414, Cp-742,033, 578h0rmp25, Cp-742033

Cas Number

481658-94-0

Unique Ingredient Identifier (UNII)

578H0RMP25

About Dirlotapide

Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human use.

Dirlotapide Manufacturers

A Dirlotapide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dirlotapide, including repackagers and relabelers. The FDA regulates Dirlotapide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dirlotapide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dirlotapide Suppliers

A Dirlotapide supplier is an individual or a company that provides Dirlotapide active pharmaceutical ingredient (API) or Dirlotapide finished formulations upon request. The Dirlotapide suppliers may include Dirlotapide API manufacturers, exporters, distributors and traders.

Dirlotapide GMP

Dirlotapide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dirlotapide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dirlotapide GMP manufacturer or Dirlotapide GMP API supplier for your needs.

Dirlotapide CoA

A Dirlotapide CoA (Certificate of Analysis) is a formal document that attests to Dirlotapide's compliance with Dirlotapide specifications and serves as a tool for batch-level quality control.

Dirlotapide CoA mostly includes findings from lab analyses of a specific batch. For each Dirlotapide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dirlotapide may be tested according to a variety of international standards, such as European Pharmacopoeia (Dirlotapide EP), Dirlotapide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dirlotapide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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