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Dimethindene
Also known as: Dimetindene maleate, 3614-69-5, Forhistal maleate, Dimethpyrindene maleate, Fenistil-retard, Dimethinden maleate
Molecular Formula
C24H28N2O4
Molecular Weight
408.5  g/mol
InChI Key
SWECWXGUJQLXJF-BTJKTKAUSA-N
FDA UNII
6LL60J9E0O

A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
1 2D Structure

Dimethindene

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
2.1.2 InChI
InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
2.1.3 InChI Key
SWECWXGUJQLXJF-BTJKTKAUSA-N
2.1.4 Canonical SMILES
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
6LL60J9E0O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dimethindene

2. Dimethpyrindene

3. Dimetindene

4. Fenistil

5. Forhistal

6. Maleate, Dimethindene

2.3.2 Depositor-Supplied Synonyms

1. Dimetindene Maleate

2. 3614-69-5

3. Forhistal Maleate

4. Dimethpyrindene Maleate

5. Fenistil-retard

6. Dimethinden Maleate

7. Fenistil

8. Su-6518

9. Dimethindene Maleate [usan]

10. Su 6518

11. Dimethindene (maleate)

12. Nsc-107677

13. Mls002704010

14. 6ll60j9e0o

15. 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)pyridine Maleate (1:1)

16. Triten

17. (z)-but-2-enedioic Acid;n,n-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1h-inden-2-yl]ethanamine

18. 1h-indene-2-ethanamine, N,n-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (z)-2-butenedioate (1:1)

19. Forthistal Maleate

20. Dimethindene Malenate

21. Dimetindene Maleate (jan)

22. But-2-enedioic Acid;n,n-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1h-inden-2-yl]ethanamine

23. Dimethindene Maleate (usan)

24. Dimetindene Hydrogen Maleate

25. Dimetindene Maleate [jan]

26. N,n-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)-1h-inden-2-yl)ethanamine Maleate

27. Nsc107677

28. Einecs 222-789-2

29. Nsc 107677

30. Unii-6ll60j9e0o

31. Dimethindenmaleat

32. 2-[1-[2-[2-(dimethylamino)ethyl]inden-3-yl]ethyl]pyridine Maleate (1:1)

33. Dimethindene Maleate [usan:usp]

34. Starbld0026265

35. Forhistal Maleate (tn)

36. 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)pyridine Maleate

37. Schembl359490

38. Chembl1870768

39. Chebi:31500

40. Dimethindene Maleate [mi]

41. Dimetindene Maleate [mart.]

42. Dimetindene Maleate [who-dd]

43. Hy-13710a

44. Mfcd00072146

45. Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-, Maleate (1:1)

46. Dimetindene Maleate [ep Monograph]

47. Smr001570719

48. Ws-01911

49. Cs-0015467

50. Z 820

51. D01343

52. F16365

53. W-106641

54. Q27265113

55. 1h-indene-2-ethanamine,n-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (z)-2-butenedioate (1:1)

56. N,n-dimethyl-2-{3-[(rs)-1-(pyridine-2-yl)ethyl]-1h-inden-2-yl}ethanamin-(z)-butendioate

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 408.5 g/mol
Molecular Formula C24H28N2O4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass408.20490738 g/mol
Monoisotopic Mass408.20490738 g/mol
Topological Polar Surface Area90.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity518
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipruritics

Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)


Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


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