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Dihydralazine Sulfate

Synopsis, Chemistry

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Also known as: 7327-87-9, Dihydralazine sulphate, Depressan, 1,4-dihydrazinophthalazine sulfate, Hydralazine sulfate, 1,4-dihydrazinylphthalazine sulfate

Molecular Formula

C₈H₁₂N₆O₄S

Molecular Weight

288.29 g/mol

InChI Key

BWHAMWGGORIDBK-UHFFFAOYSA-N

FDA UNII

1C2B1W91NK

1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)

1 2D Structure

Dihydralazine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4-hydrazinylphthalazin-1-yl)hydrazine;sulfuric acid

2.1.2 InChI

InChI=1S/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4)

2.1.3 InChI Key

BWHAMWGGORIDBK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C2C(=C1)C(=NN=C2NN)NN.OS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

1C2B1W91NK

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Depressan

2. Dihydralazine

3. Dihydrallazine

4. Dihydrazinophthalazin

5. Sulfate, Dihydralazine

2.3.2 Depositor-Supplied Synonyms

1. 7327-87-9

2. Dihydralazine Sulphate

3. Depressan

4. 1,4-dihydrazinophthalazine Sulfate

5. Hydralazine Sulfate

6. 1,4-dihydrazinylphthalazine Sulfate

7. Nepresol

8. Ophthazin

9. 1,4-dihydrazinophthalazine Hydrogen Sulfate

10. (4-hydrazinylphthalazin-1-yl)hydrazine;sulfuric Acid

11. 1c2b1w91nk

12. Ophthazin Sulfate

13. Ccris 5386

14. Sulfate De Dihydralazine [french]

15. Sulfate De Dihydralazine

16. Einecs 230-808-0

17. Unii-1c2b1w91nk

18. Dihydralazinsulfat

19. Phthalazine, 1,4-dihydrazino-, Sulfate (1:1)

20. Nepresol (tn)

21. Dihydralazine Sulfate,(s)

22. Dihydralazine Hydrogen Sulfate

23. Schembl1374523

24. Chembl2106266

25. Dtxsid10223501

26. Dihydralazine Sulfate [mi]

27. Bcp11859

28. Dihydralazine For System Suitability

29. Hy-n7065

30. Mfcd00035271

31. S5030

32. Dihydralazine Sulfate [mart.]

33. Akos015960760

34. Akos037643215

35. Dihydralazine Sulfate [who-dd]

36. Ccg-267357

37. Cs-w012211

38. Sb67406

39. Ac-12152

40. As-10957

41. Ft-0731572

42. (4-hydrazinylphthalazin-1-yl)hydrazine Sulfate

43. C76337

44. D07830

45. 327d879

46. A920291

47. 1,4-dihydrazinophthalazine Hydrogen Sulphate

48. W-104459

49. Q27252218

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₈H₁₂N₆O₄S
Molecular Weight	288.29 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	2
Exact Mass	288.06407406 g/mol
Monoisotopic Mass	288.06407406 g/mol
Topological Polar Surface Area	185 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	248
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)