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Chemistry

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Also known as: 2377000-84-3, Dencatistat, Dencatistat [inn], Qg9c9szz3t, Orb2566577, Chembl5436583
Molecular Formula
C24H27N7O5S
Molecular Weight
525.6  g/mol
InChI Key
WVCJRTCHVUNXST-UHFFFAOYSA-N
FDA UNII
QG9C9SZZ3T

Dencatistat
Dencatistat is an orally bioavailable, small molecule inhibitor of cytidine triphosphate synthase 1 (CTPS1), with potential antineoplastic activity. Upon oral administration, dencatistat targets, binds to and inhibits the activity of CTPS1, thereby decreasing the production of cytidine triphosphate (CTP), an essential building block of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). This may disrupt DNA and RNA synthesis and trigger apoptosis. CTPS1, an enzyme that catalyzes the rate-limiting step in pyrimidine synthesis, plays an important and nonredundant role in B-cell and T-cell proliferation. CTPS1 is required for rapid cell division in certain types of cancers that arise from blood cells.
1 2D Structure

Dencatistat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[2-(cyclopropylsulfonylamino)pyrimidin-4-yl]-N-[5-(6-ethoxypyrazin-2-yl)-2-pyridinyl]oxane-4-carboxamide
2.1.2 InChI
InChI=1S/C24H27N7O5S/c1-2-36-21-15-25-14-18(28-21)16-3-6-20(27-13-16)30-22(32)24(8-11-35-12-9-24)19-7-10-26-23(29-19)31-37(33,34)17-4-5-17/h3,6-7,10,13-15,17H,2,4-5,8-9,11-12H2,1H3,(H,26,29,31)(H,27,30,32)
2.1.3 InChI Key
WVCJRTCHVUNXST-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
QG9C9SZZ3T
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 2377000-84-3

2. Dencatistat

3. Dencatistat [inn]

4. Qg9c9szz3t

5. Orb2566577

6. Chembl5436583

7. Schembl21381421

8. Schembl29791279

9. Hy-157783

10. Cs-0998846

11. 2h-pyran-4-carboxamide, 4-[2-[(cyclopropylsulfonyl)amino]-4-pyrimidinyl]-n-[5-(6-ethoxy-2-pyrazinyl)-2-pyridinyl]tetrahydro-

12. 4-[2-(cyclopropanesulfonamido)pyrimidin-4-yl]-n-[5-(6-ethoxypyrazin-2-yl)pyridin-2-yl]oxane-4-carboxamide

13. 4-[2-[(cyclopropylsulfonyl)amino]-4-pyrimidinyl]-n-[5-(6-ethoxy-2-pyrazinyl)-2-pyridinyl]tetrahydro-2h-pyran-4-carboxamide

2.4 Create Date
2019-11-02
3 Chemical and Physical Properties
Molecular Weight 525.6 g/mol
Molecular Formula C24H27N7O5S
XLogP30.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area167
Heavy Atom Count37
Formal Charge0
Complexity877
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 2377000-84-3 / Dencatistat API manufacturers, exporters & distributors?

Dencatistat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Dencatistat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Dencatistat manufacturer or Dencatistat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Dencatistat manufacturer or Dencatistat supplier.

API | Excipient name

Dencatistat

Synonyms

2377000-84-3, Dencatistat [inn], Qg9c9szz3t, Orb2566577, Chembl5436583, Schembl21381421

Cas Number

2377000-84-3

Unique Ingredient Identifier (UNII)

QG9C9SZZ3T

About Dencatistat

Dencatistat is an orally bioavailable, small molecule inhibitor of cytidine triphosphate synthase 1 (CTPS1), with potential antineoplastic activity. Upon oral administration, dencatistat targets, binds to and inhibits the activity of CTPS1, thereby decreasing the production of cytidine triphosphate (CTP), an essential building block of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). This may disrupt DNA and RNA synthesis and trigger apoptosis. CTPS1, an enzyme that catalyzes the rate-limiting step in pyrimidine synthesis, plays an important and nonredundant role in B-cell and T-cell proliferation. CTPS1 is required for rapid cell division in certain types of cancers that arise from blood cells.

Dencatistat Manufacturers

A Dencatistat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dencatistat, including repackagers and relabelers. The FDA regulates Dencatistat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dencatistat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dencatistat Suppliers

A Dencatistat supplier is an individual or a company that provides Dencatistat active pharmaceutical ingredient (API) or Dencatistat finished formulations upon request. The Dencatistat suppliers may include Dencatistat API manufacturers, exporters, distributors and traders.

Dencatistat GMP

Dencatistat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dencatistat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Dencatistat GMP manufacturer or Dencatistat GMP API supplier for your needs.

Dencatistat CoA

A Dencatistat CoA (Certificate of Analysis) is a formal document that attests to Dencatistat's compliance with Dencatistat specifications and serves as a tool for batch-level quality control.

Dencatistat CoA mostly includes findings from lab analyses of a specific batch. For each Dencatistat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dencatistat may be tested according to a variety of international standards, such as European Pharmacopoeia (Dencatistat EP), Dencatistat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dencatistat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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