LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

Munit offers scalable GMP micronization and particle size engineering to enhance drug solubility, bioavailability, and performance.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

API REF. PRICE (USD/KG)

$ 0

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Regulatory FDF Prices

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

API

FDF

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 2377000-84-3, Dencatistat, Dencatistat [inn], Qg9c9szz3t, Orb2566577, Chembl5436583

Molecular Formula

C₂₄H₂₇N₇O₅S

Molecular Weight

525.6 g/mol

InChI Key

WVCJRTCHVUNXST-UHFFFAOYSA-N

FDA UNII

QG9C9SZZ3T

Dencatistat is an orally bioavailable, small molecule inhibitor of cytidine triphosphate synthase 1 (CTPS1), with potential antineoplastic activity. Upon oral administration, dencatistat targets, binds to and inhibits the activity of CTPS1, thereby decreasing the production of cytidine triphosphate (CTP), an essential building block of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). This may disrupt DNA and RNA synthesis and trigger apoptosis. CTPS1, an enzyme that catalyzes the rate-limiting step in pyrimidine synthesis, plays an important and nonredundant role in B-cell and T-cell proliferation. CTPS1 is required for rapid cell division in certain types of cancers that arise from blood cells.

1 2D Structure

Dencatistat

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[2-(cyclopropylsulfonylamino)pyrimidin-4-yl]-N-[5-(6-ethoxypyrazin-2-yl)-2-pyridinyl]oxane-4-carboxamide

2.1.2 InChI

InChI=1S/C24H27N7O5S/c1-2-36-21-15-25-14-18(28-21)16-3-6-20(27-13-16)30-22(32)24(8-11-35-12-9-24)19-7-10-26-23(29-19)31-37(33,34)17-4-5-17/h3,6-7,10,13-15,17H,2,4-5,8-9,11-12H2,1H3,(H,26,29,31)(H,27,30,32)

2.1.3 InChI Key

WVCJRTCHVUNXST-UHFFFAOYSA-N

2.2 Other Identifiers

2.2.1 UNII

QG9C9SZZ3T

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 2377000-84-3

2. Dencatistat

3. Dencatistat [inn]

4. Qg9c9szz3t

5. Orb2566577

6. Chembl5436583

7. Schembl21381421

8. Schembl29791279

9. Hy-157783

10. Cs-0998846

11. 2h-pyran-4-carboxamide, 4-[2-[(cyclopropylsulfonyl)amino]-4-pyrimidinyl]-n-[5-(6-ethoxy-2-pyrazinyl)-2-pyridinyl]tetrahydro-

12. 4-[2-(cyclopropanesulfonamido)pyrimidin-4-yl]-n-[5-(6-ethoxypyrazin-2-yl)pyridin-2-yl]oxane-4-carboxamide

13. 4-[2-[(cyclopropylsulfonyl)amino]-4-pyrimidinyl]-n-[5-(6-ethoxy-2-pyrazinyl)-2-pyridinyl]tetrahydro-2h-pyran-4-carboxamide

2.4 Create Date

2019-11-02

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₇N₇O₅S
Molecular Weight	525.6 g/mol
XLogP3	0.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	9
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	167
Heavy Atom Count	37
Formal Charge	0
Complexity	877
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1