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1. 2'-chloronordiazepam
2. 7-chloro-5-(2-chlorophenyl) 1,3-dihydro-2h-1,4-benzodiazepin-2-one
3. Chlordemethyldiazepam
4. Chlordesmethyldiazepam
5. Chlorodesmethyldiazepam
1. 2894-67-9
2. Chlordemethyldiazepam
3. B1, Benzodiazepine
4. Delorazepam [inn]
5. Cl-dmdz
6. Clordesmetildiazepam
7. En [anticonvulsant]
8. Dadumir
9. Ro 5-3027
10. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-
11. 7-chloro-5-(2-chloro-phenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one
12. Nsc 169895
13. Rv-12165
14. 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
15. Nsc-169895
16. Chembl268254
17. 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-2h-1,4-benzodiazepin-2-one
18. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-
19. 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one
20. 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one
21. Delorazepam (inn)
22. O91w32476g
23. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-chlorophenyl)-
24. 2-chloronordiazepam
25. 2'-chloronordiazepam
26. Delorazepamum
27. Delorazepamum [inn-latin]
28. Clordesmetildiazepam [spanish]
29. Einecs 220-771-9
30. Brn 0754062
31. Dea No. 2754
32. Unii-o91w32476g
33. Dadumir (tn)
34. Cambridge Id 6782587
35. Delorazepam [mart.]
36. Oprea1_689003
37. Delorazepam [who-dd]
38. 5-24-04-00331 (beilstein Handbook Reference)
39. Schembl157332
40. O-chlorodesmethyldiazepam
41. Delorazepam--dea Schedule Iv Item
42. Dtxsid70183137
43. Chebi:135295
44. Delorazepam 0.1 Mg/ml In Methanol
45. Zinc1255325
46. Bdbm50026858
47. Nsc169895
48. Stk072416
49. Stl149558
50. Akos002312613
51. Akos005749640
52. Db01511
53. Wln: T67 Gmv Jn Ihj Cg Kr Bg
54. Ac-15739
55. Db-008912
56. D07784
57. Ab00119043-01
58. 894d679
59. Sr-01000243030
60. 2h-1, 1,3-dihydro-7-chloro-5-(2-chlorophenyl)-
61. 2h-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-
62. 2h-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-
63. Q3705147
64. Sr-01000243030-1
65. W-107017
66. 7-chloro-5-(2-chlorophenyl)-3h-1,4-benzodiazepin-2-ol
67. 7-chloro-5-(2-chlorophenyl)-1h-benzo[e][1,4]diazepin-2(3h)-one
68. (e)-7-chloro-5-(2-chlorophenyl)-1h-benzo[e][1,4]diazepin-2(3h)-one
69. 1,3-dihydro-7-chloro-5-(2-chlorophenyl)-2h-1,4-benzodiazepin-2-one
70. 7-chloro-5-(2'-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one
71. 7-chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
72. Delorazepam Solution, 100 Mug/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 305.2 g/mol |
|---|---|
| Molecular Formula | C15H10Cl2N2O |
| XLogP3 | 3.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 304.0170183 g/mol |
| Monoisotopic Mass | 304.0170183 g/mol |
| Topological Polar Surface Area | 41.5 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 413 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Mainly used as an anti-anxiety agent. Studies have found delorazepam to be more effective in the first 4 weeks of use than antidepressants; however, after 4 weeks, antidepressants showed superior anti-anxiety effects. Anti-anxiety effects also appear to be weaker in elderly patients. Effectiveness has also been observed in the treatment of alcohol withdrawal. Delorazapam was reported to be a manageable drug in that it did not exhibit severe side effects and did not require further therapies to control symptoms of withdrawal.
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)
Absorption
77-87% oral bioavailability, with a relatively slow absorption rate. Reaches peak plasma levels within 1-2 hours of administration. Food may slow absorption, however other pharmacokinetic variables remain unchanged. After multiple doses delorazepam accumulates, although accumulation is slower in younger patients.
Route of Elimination
Renally eliminated.
Volume of Distribution
140 L/kg apparent volume of distribution in 11 patients with normal renal function; 47 L/kg in 11 patients with renal failure and on regular hemodialysis. In another study, apparent volume of distribution was 65 L/kg in 8 patients with liver disease and 118.4 L/kg in 12 healthy controls.
Clearance
Still detectable 72 hours after dosing in healthy patients. Patients with liver disease experienced a reduction in clearance from 0.13 to 0.25 ng/mLh.
Delorazepam is metabolized at a relatively slow pace by the liver. The major metabolite (15-34% of the parent drug) is lorazepam. Older patients metabolize delorazepam slower than younger patients.
Very long elimination half life of 80-115 hours, varying with age. Elimination is slower as age increases. [1] Liver disease also impacts elimination half life, with impairment resulting in half lives up to 395 hours.
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