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Chemistry

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Also known as:
Molecular Formula
C21H15N3O4
Molecular Weight
373.4  g/mol
InChI Key
FMSOAWSKCWYLBB-VBGLAJCLSA-N

Deferasirox
1 2D Structure

Deferasirox

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(3Z,5E)-3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
2.1.2 InChI
InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,22-23H,(H,27,28)/b19-15-,20-16+
2.1.3 InChI Key
FMSOAWSKCWYLBB-VBGLAJCLSA-N
2.1.4 Canonical SMILES
C1=CC(=C2NC(=C3C=CC=CC3=O)N(N2)C4=CC=C(C=C4)C(=O)O)C(=O)C=C1
2.1.5 Isomeric SMILES
C1=C/C(=C/2\N/C(=C\3/C=CC=CC3=O)/N(N2)C4=CC=C(C=C4)C(=O)O)/C(=O)C=C1
2.2 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 373.4 g/mol
Molecular Formula C21H15N3O4
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass373.10625597 g/mol
Monoisotopic Mass373.10625597 g/mol
Topological Polar Surface Area98.7 A^2
Heavy Atom Count28
Formal Charge0
Complexity912
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameExjade
PubMed HealthDeferasirox (By mouth)
Drug ClassesHeavy Metal Chelator
Drug LabelExjade(deferasirox) is an iron chelating agent. Exjade tablets for oral suspension contain 125mg, 250mg, or 500mg deferasirox. Deferasirox is designated chemically as 4-[3,5-Bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid and its st...
Active IngredientDeferasirox
Dosage FormTablet, for suspension
RouteOral
Strength250mg; 125mg; 500mg
Market StatusPrescription
CompanyNovartis

2 of 2  
Drug NameExjade
PubMed HealthDeferasirox (By mouth)
Drug ClassesHeavy Metal Chelator
Drug LabelExjade(deferasirox) is an iron chelating agent. Exjade tablets for oral suspension contain 125mg, 250mg, or 500mg deferasirox. Deferasirox is designated chemically as 4-[3,5-Bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid and its st...
Active IngredientDeferasirox
Dosage FormTablet, for suspension
RouteOral
Strength250mg; 125mg; 500mg
Market StatusPrescription
CompanyNovartis

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18-Jan-2022
28-May-2025
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DOSAGE - GRANULE;ORAL - 180MG

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Looking for / Deferasirox API manufacturers, exporters & distributors?

Deferasirox manufacturers, exporters & distributors 1

58

PharmaCompass offers a list of Deferasirox API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Deferasirox manufacturer or Deferasirox supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Deferasirox manufacturer or Deferasirox supplier.

PharmaCompass also assists you with knowing the Deferasirox API Price utilized in the formulation of products. Deferasirox API Price is not always fixed or binding as the Deferasirox Price is obtained through a variety of data sources. The Deferasirox Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Deferasirox

Deferasirox Manufacturers

A Deferasirox manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Deferasirox, including repackagers and relabelers. The FDA regulates Deferasirox manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Deferasirox API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Deferasirox manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Deferasirox Suppliers

A Deferasirox supplier is an individual or a company that provides Deferasirox active pharmaceutical ingredient (API) or Deferasirox finished formulations upon request. The Deferasirox suppliers may include Deferasirox API manufacturers, exporters, distributors and traders.

click here to find a list of Deferasirox suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Deferasirox USDMF

A Deferasirox DMF (Drug Master File) is a document detailing the whole manufacturing process of Deferasirox active pharmaceutical ingredient (API) in detail. Different forms of Deferasirox DMFs exist exist since differing nations have different regulations, such as Deferasirox USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Deferasirox DMF submitted to regulatory agencies in the US is known as a USDMF. Deferasirox USDMF includes data on Deferasirox's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Deferasirox USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Deferasirox suppliers with USDMF on PharmaCompass.

Deferasirox JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Deferasirox Drug Master File in Japan (Deferasirox JDMF) empowers Deferasirox API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Deferasirox JDMF during the approval evaluation for pharmaceutical products. At the time of Deferasirox JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Deferasirox suppliers with JDMF on PharmaCompass.

Deferasirox KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Deferasirox Drug Master File in Korea (Deferasirox KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Deferasirox. The MFDS reviews the Deferasirox KDMF as part of the drug registration process and uses the information provided in the Deferasirox KDMF to evaluate the safety and efficacy of the drug.

After submitting a Deferasirox KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Deferasirox API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Deferasirox suppliers with KDMF on PharmaCompass.

Deferasirox CEP

A Deferasirox CEP of the European Pharmacopoeia monograph is often referred to as a Deferasirox Certificate of Suitability (COS). The purpose of a Deferasirox CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Deferasirox EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Deferasirox to their clients by showing that a Deferasirox CEP has been issued for it. The manufacturer submits a Deferasirox CEP (COS) as part of the market authorization procedure, and it takes on the role of a Deferasirox CEP holder for the record. Additionally, the data presented in the Deferasirox CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Deferasirox DMF.

A Deferasirox CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Deferasirox CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Deferasirox suppliers with CEP (COS) on PharmaCompass.

Deferasirox WC

A Deferasirox written confirmation (Deferasirox WC) is an official document issued by a regulatory agency to a Deferasirox manufacturer, verifying that the manufacturing facility of a Deferasirox active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Deferasirox APIs or Deferasirox finished pharmaceutical products to another nation, regulatory agencies frequently require a Deferasirox WC (written confirmation) as part of the regulatory process.

click here to find a list of Deferasirox suppliers with Written Confirmation (WC) on PharmaCompass.

Deferasirox NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Deferasirox as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Deferasirox API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Deferasirox as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Deferasirox and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Deferasirox NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Deferasirox suppliers with NDC on PharmaCompass.

Deferasirox GMP

Deferasirox Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Deferasirox GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Deferasirox GMP manufacturer or Deferasirox GMP API supplier for your needs.

Deferasirox CoA

A Deferasirox CoA (Certificate of Analysis) is a formal document that attests to Deferasirox's compliance with Deferasirox specifications and serves as a tool for batch-level quality control.

Deferasirox CoA mostly includes findings from lab analyses of a specific batch. For each Deferasirox CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Deferasirox may be tested according to a variety of international standards, such as European Pharmacopoeia (Deferasirox EP), Deferasirox JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Deferasirox USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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