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CX717

CX717

Synopsis, Chemistry

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Also known as: Cx717, 867276-98-0, Cx-717, Unii-7i12yta3qm, 7i12yta3qm, Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone

Molecular Formula

C₁₁H₁₁N₃O₃

Molecular Weight

233.22 g/mol

InChI Key

KFRQROSRKSVROW-UHFFFAOYSA-N

FDA UNII

7I12YTA3QM

CX-717 is an ampakine compound previously investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.

1 2D Structure

CX717

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone

2.1.2 InChI

InChI=1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2

2.1.3 InChI Key

KFRQROSRKSVROW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1COCCN1C(=O)C2=CC3=NON=C3C=C2

2.2 Other Identifiers

2.2.1 UNII

7I12YTA3QM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cx717

2.3.2 Depositor-Supplied Synonyms

1. Cx717

2. 867276-98-0

3. Cx-717

4. Unii-7i12yta3qm

5. 7i12yta3qm

6. Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone

7. 2,1,3-benzoxadiazol-5-yl-4-morpholinylmethanone

8. Cx 717

9. Morpholine, 4-(2,1,3-benzoxadiazol-5-ylcarbonyl)-

10. 211735-82-9

11. Starbld0003244

12. Cx 717 (pharmaceutical)

13. Oprea1_513346

14. Schembl243542

15. Chembl4791762

16. Dtxsid301241632

17. Ex-a6414

18. Db05047

19. Bs-47001

20. Cs-0256234

2.4 Create Date

2005-09-07

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₁N₃O₃
Molecular Weight	233.22 g/mol
XLogP3	0.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	233.08004122 g/mol
Monoisotopic Mass	233.08004122 g/mol
Topological Polar Surface Area	68.5 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	294
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

CX-717 is an ampakine compound. It is a positive allosteric modulator of AMPA receptors. Its action is theorized to be due to the facilitation of transmission at cortical synapses that use glutamate as a neurotransmitter. This in turn may promote plasticity at the synapse, which could translate into better cognitive performance. CX-717 works by allosterically binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. In addition, CX717 could potentially strongly impact the up-regulation of BDNF (brain-derived neurotrophic factor) or NGF (nerve growth factor), two growth factors known to stimulate the formation of new circuitry in the brain associated with forming memory and cognition.