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    Chemistry

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    Also known as: Cortisone 21-acetate, 50-04-4, Cortone acetate, Incortin, Biocort acetate, Artriona
    Molecular Formula
    C23H30O6
    Molecular Weight
    402.5  g/mol
    InChI Key
    ITRJWOMZKQRYTA-RFZYENFJSA-N
    FDA UNII
    883WKN7W8X
    Cortisone
    A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
    1 2D Structure

    Cortisone

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
    2.1.2 InChI
    InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1
    2.1.3 InChI Key
    ITRJWOMZKQRYTA-RFZYENFJSA-N
    2.1.4 Canonical SMILES
    CC(=O)OCC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)CCC34C)C)O
    2.1.5 Isomeric SMILES
    CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
    2.2 Other Identifiers
    2.2.1 UNII
    883WKN7W8X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl Acetate

    2. Adreson

    3. Cortisone

    4. Cortone Acetate

    2.3.2 Depositor-Supplied Synonyms

    1. Cortisone 21-acetate

    2. 50-04-4

    3. Cortone Acetate

    4. Incortin

    5. Biocort Acetate

    6. Artriona

    7. Cortadren

    8. Scheroson

    9. Cortisyl

    10. Adreson

    11. Irisone Acetate

    12. Cortelan

    13. Cortistab

    14. Ricortex

    15. Cortogen Acetate

    16. Compound E Acetate

    17. Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-

    18. Cortisone Monoacetate

    19. Nsc 49420

    20. Cortisone, 21-acetate

    21. Cortilen

    22. Cortisone Aceticum

    23. 11-dehydro-17-hydroxycorticosterone-21-acetate

    24. 11-dehydro-17-hydroxycorticosterone Acetate

    25. 17,21-dihydroxypregn-4-ene-3,11,20-trione 21-acetate

    26. Nsc-49420

    27. 883wkn7w8x

    28. Chebi:3897

    29. Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate

    30. Cortisone (acetate)

    31. Ncgc00021191-07

    32. 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl Acetate

    33. Dsstox_cid_2858

    34. Dsstox_rid_76761

    35. Dsstox_gsid_22858

    36. 17,21-dihydroxypregn-4-ene-3,11,20-trione-21-acetate

    37. 17alpha,21-dihydroxypregn-4-ene-3,11,20-trione Acetate

    38. Cas-50-04-4

    39. [2-[(8s,9s,10r,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

    40. 2-((8s,9s,10r,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate

    41. Smr000059124

    42. Ccris 3661

    43. Cortisone Acetate (cortone)

    44. Einecs 200-006-5

    45. Unii-883wkn7w8x

    46. Cortisoneacetate

    47. Cortisone Acetate [usp:jan]

    48. Acetate Cortisone

    49. Cortisyl Artriona

    50. Component Of Neosone

    51. Mfcd00003609

    52. Neosone (salt/mix)

    53. 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione

    54. Cortisone-21-acetate

    55. 21-acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4

    56. 21-acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione

    57. Cortone Acetate (tn)

    58. 4-pregnene-17,alpha,21-diol-3,11,20-trione 21-acetate

    59. Schembl4501

    60. Chembl1650

    61. Lopac0_000271

    62. Mls000069478

    63. Mls002207136

    64. Mls002548859

    65. 21-acetoxy-4-pregnen-17alpha-ol-3,11,20-trione

    66. Cortisone Acetate [jan]

    67. Cortisone Acetate (jp17/usp)

    68. Dtxsid0022858

    69. Cortisone 21-acetate, >=99%

    70. Cortisone Acetate [vandf]

    71. Cortisone Aceticum [hpus]

    72. Cortisone Acetate [mart.]

    73. 17alpha,21-dihydroxy-4-pregnene-3,11,20-trione 21-acetate

    74. Hms2235d24

    75. Hms3259n19

    76. Hms3260h04

    77. Cortisone Acetate [usp-rs]

    78. Cortisone Acetate [who-dd]

    79. Bcp08487

    80. Cortisone 21-acetate [mi]

    81. Nsc49420

    82. Zinc3875334

    83. Tox21_113482

    84. Tox21_500271

    85. Bdbm50455157

    86. Hy-17461a

    87. Lmst02030120

    88. Akos005267225

    89. Tox21_113482_1

    90. Ac-6827

    91. Ccg-204366

    92. Cortisone Acetate [orange Book]

    93. Cs-1742

    94. Db01380

    95. Lp00271

    96. Nc00677

    97. Sdccgsbi-0050259.p002

    98. Cortisone Acetate [ep Monograph]

    99. Cortisone Acetate [usp Monograph]

    100. Ncgc00021191-03

    101. Ncgc00021191-06

    102. Ncgc00021191-08

    103. Ncgc00021191-09

    104. Ncgc00021191-16

    105. Ncgc00260956-01

    106. [2-[(8s,9s,10r,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] Acetate

    107. 2-((1s,10s,11s,15s,2r,14r)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0 .0<2,7>.0<11,15>]heptadec-6-en-14-yl)-2-oxoethyl Acetate

    108. As-13692

    109. Cortisone Acetate 100 Microg/ml In Methanol

    110. Eu-0100271

    111. S2559

    112. C08173

    113. C90609

    114. D00973

    115. Ab00384283-08

    116. Ab00384283_09

    117. Cortisone Acetate 100 Microg/ml In Acetonitrile

    118. 003c609

    119. W-105993

    120. Brd-k86161929-001-13-3

    121. Hydrocortisone Acetate Impurity D [ep Impurity]

    122. Pregn-4-ene-3,20-trione, 21-(acetyloxy)-17-hydroxy-

    123. 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl Acetate #

    124. 21-acetoxy-17.alpha.-hydroxy-3,11,20-triketopregnene-4

    125. 21-acetoxy-17.alpha.-hydroxypregn-4-ene-3,11,20-trione

    126. 4-pregnen-17.alpha.,21-diol-3,11,20-trione 21-acetate

    127. Pregn-4-ene-3,20-trione, 17,21-dihydroxy-, 21-acetate

    128. 4-pregnene-17.alpha.,21-diol-3,11,20-trione 21-acetate

    129. Cortisone Acetate, European Pharmacopoeia (ep) Reference Standard

    130. Cortisone Acetate, United States Pharmacopeia (usp) Reference Standard

    131. Cortisone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 402.5 g/mol
    Molecular Formula C23H30O6
    XLogP32.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass402.20423867 g/mol
    Monoisotopic Mass402.20423867 g/mol
    Topological Polar Surface Area97.7 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity827
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameCortisone acetate
    PubMed HealthCortisone Acetate (By mouth)
    Drug ClassesEndocrine-Metabolic Agent, Immune Suppressant
    Drug LabelGlucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.Cortisone acetate is a white or practically white, odorless, crystalline powder. It is stable in air. It i...
    Active IngredientCortisone acetate
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyHikma Pharms

    2 of 2  
    Drug NameCortisone acetate
    PubMed HealthCortisone Acetate (By mouth)
    Drug ClassesEndocrine-Metabolic Agent, Immune Suppressant
    Drug LabelGlucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.Cortisone acetate is a white or practically white, odorless, crystalline powder. It is stable in air. It i...
    Active IngredientCortisone acetate
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyHikma Pharms

    4.2 Drug Indication

    Cortisone acetate is indicated to treat a wide variety of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. The duration of action is moderate as it is generally given once daily. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

    5.2 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
    5.4 Absorption, Distribution and Excretion

    Route of Elimination

    Corticosteroids are eliminated predominantly in the urine.

    Clearance

    Data regarding the clearance of cortisone acetate is not readily available.

    5.5 Mechanism of Action

    The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.

    API Reference Price

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MAHARASHTRA,? 400020"},{"dataSource":"API Import","activeIngredients":"","year":"2026","qtr":"Q1","strtotime":1771525800,"product":"HYDROCORTISONE EP","address":"PLOT NO. 25 \/ 1, PHASE-III,","city":"AHMEDABAD","supplier":"AQUATIC REMEDIES","supplierCountry":"CHINA","foreign_port":"HANGZHOU","customer":"NEXUS PHARMA CHEM PRIVATE LTD","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"160.5","totalValueFC":"65000.3","currency":"USD","unitRateINR":"14750","date":"20-Feb-2026","totalValueINR":"5900000","totalValueInUsd":"65000.3","indian_port":"ARSHIYA-SEZ\/PANVEL","hs_no":"29372100","bill_no":"11","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGZHOU","supplierAddress":"1209,1210,1211,CABIN A,12TH FLOOR, UNIVERSAL MAJESTIC, P L LOKHANDE MA RG CH CHEMBUR,MAHARASHT , MAHARASHT INDIA","customerAddress":"PLOT NO. 25 \/ 1, PHASE-III,"}]
    03-Jan-2022
    26-Feb-2026
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    ABOUT THIS PAGE

    Looking for 50-04-4 / Cortisone API manufacturers, exporters & distributors?

    Cortisone manufacturers, exporters & distributors 1

    75

    PharmaCompass offers a list of Cortisone API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cortisone manufacturer or Cortisone supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cortisone manufacturer or Cortisone supplier.

    PharmaCompass also assists you with knowing the Cortisone API Price utilized in the formulation of products. Cortisone API Price is not always fixed or binding as the Cortisone Price is obtained through a variety of data sources. The Cortisone Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Cortisone

    Synonyms

    Cortisone 21-acetate, 50-04-4, Cortone acetate, Incortin, Biocort acetate, Artriona

    Cas Number

    50-04-4

    Unique Ingredient Identifier (UNII)

    883WKN7W8X

    About Cortisone

    A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

    Cortogen acetate Manufacturers

    A Cortogen acetate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cortogen acetate, including repackagers and relabelers. The FDA regulates Cortogen acetate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cortogen acetate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Cortogen acetate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Cortogen acetate Suppliers

    A Cortogen acetate supplier is an individual or a company that provides Cortogen acetate active pharmaceutical ingredient (API) or Cortogen acetate finished formulations upon request. The Cortogen acetate suppliers may include Cortogen acetate API manufacturers, exporters, distributors and traders.

    click here to find a list of Cortogen acetate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Cortogen acetate USDMF

    A Cortogen acetate DMF (Drug Master File) is a document detailing the whole manufacturing process of Cortogen acetate active pharmaceutical ingredient (API) in detail. Different forms of Cortogen acetate DMFs exist exist since differing nations have different regulations, such as Cortogen acetate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Cortogen acetate DMF submitted to regulatory agencies in the US is known as a USDMF. Cortogen acetate USDMF includes data on Cortogen acetate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cortogen acetate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Cortogen acetate suppliers with USDMF on PharmaCompass.

    Cortogen acetate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Cortogen acetate Drug Master File in Japan (Cortogen acetate JDMF) empowers Cortogen acetate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Cortogen acetate JDMF during the approval evaluation for pharmaceutical products. At the time of Cortogen acetate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Cortogen acetate suppliers with JDMF on PharmaCompass.

    Cortogen acetate CEP

    A Cortogen acetate CEP of the European Pharmacopoeia monograph is often referred to as a Cortogen acetate Certificate of Suitability (COS). The purpose of a Cortogen acetate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Cortogen acetate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Cortogen acetate to their clients by showing that a Cortogen acetate CEP has been issued for it. The manufacturer submits a Cortogen acetate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Cortogen acetate CEP holder for the record. Additionally, the data presented in the Cortogen acetate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Cortogen acetate DMF.

    A Cortogen acetate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Cortogen acetate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Cortogen acetate suppliers with CEP (COS) on PharmaCompass.

    Cortogen acetate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cortogen acetate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Cortogen acetate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Cortogen acetate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Cortogen acetate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cortogen acetate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Cortogen acetate suppliers with NDC on PharmaCompass.

    Cortogen acetate GMP

    Cortogen acetate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Cortogen acetate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cortogen acetate GMP manufacturer or Cortogen acetate GMP API supplier for your needs.

    Cortogen acetate CoA

    A Cortogen acetate CoA (Certificate of Analysis) is a formal document that attests to Cortogen acetate's compliance with Cortogen acetate specifications and serves as a tool for batch-level quality control.

    Cortogen acetate CoA mostly includes findings from lab analyses of a specific batch. For each Cortogen acetate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Cortogen acetate may be tested according to a variety of international standards, such as European Pharmacopoeia (Cortogen acetate EP), Cortogen acetate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cortogen acetate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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