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    Chemistry

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    Also known as: 22204-24-6, Pyrantel embonate, Antiminth, Combantrin, Pyrantel (pamoate), Cp-10,423-16
    Molecular Formula
    C34H30N2O6S
    Molecular Weight
    594.7  g/mol
    InChI Key
    AQXXZDYPVDOQEE-MXDQRGINSA-N
    FDA UNII
    81BK194Z5M
    Pyrantel Pamoate
    Broad spectrum antinematodal anthelmintic used also in veterinary medicine.
    1 2D Structure

    Pyrantel Pamoate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
    2.1.2 InChI
    InChI=1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2,4-6,9H,3,7-8H2,1H3/b;6-5+
    2.1.3 InChI Key
    AQXXZDYPVDOQEE-MXDQRGINSA-N
    2.1.4 Canonical SMILES
    CN1CCCN=C1C=CC2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CN1CCCN=C1/C=C/C2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    81BK194Z5M
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Antiminth

    2. Combantrin

    3. Embonate, Pyrantel

    4. Embovin

    5. Pamoate, Pyrantel

    6. Pyrantel Embonate

    2.3.2 Depositor-Supplied Synonyms

    1. 22204-24-6

    2. Pyrantel Embonate

    3. Antiminth

    4. Combantrin

    5. Pyrantel (pamoate)

    6. Cp-10,423-16

    7. Pyrantel (as Pamoate)

    8. Embovin

    9. (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate) (1:1)

    10. Nsc-355080

    11. Chebi:8655

    12. Cp 10423-16

    13. 81bk194z5m

    14. Nsc355080

    15. (e)-1-methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate)

    16. Cp-10423-16

    17. Cp-10423-18

    18. Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (e)-, Compd. With 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid) (1:1)

    19. Cobantril

    20. Sentry Hc Worm X

    21. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis[3-hydroxy-, Compd. With 1,4,5,6-tetrahydro-1-methyl-2-[(1e)-2-(2-thienyl)ethenyl]pyrimidine (1:1)

    22. 4-[(3-carboxy-2-hydroxy-1-naphthyl)methyl]-3-hydroxy-naphthalene-2-carboxylic Acid; 1-methyl-2-[(e)-2-(2-thienyl)vinyl]-5,6-dihydro-4h-pyrimidine

    23. 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic Acid;1-methyl-2-[(e)-2-thiophen-2-ylethenyl]-5,6-dihydro-4h-pyrimidine

    24. Sentry Hc Worm X Ds

    25. Einecs 244-837-1

    26. Vetscription Sure Shot 2x

    27. Nsc 355080

    28. Pyirantelpamoate

    29. Unii-81bk194z5m

    30. Pyrantel Pamoates

    31. Pyranteli Embonas

    32. Antiminth (tn)

    33. Pyrantel Pamoate [usan:usp:jan]

    34. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With 1,4,5,6-tetrahydro-1-methyl-2-((1e)-2-(2-thienyl)ethenyl)pyrimidine (1:1)

    35. Spectrum5_001373

    36. Pyrantel Pamoate, Bioxtra

    37. (3-hydroxy-2-naphthoate)

    38. Schembl41025

    39. 2-naphthalenecarboxylic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)pyrimidine (1:1)

    40. Pyrantel Pamoate [mi]

    41. Spectrum1500517

    42. Pyrantel Pamoate [jan]

    43. Pyrantel Pamoate (jp17/usp)

    44. Schembl7793068

    45. Pyrantel Pamoate [usan]

    46. Chembl1599768

    47. Pyrantel Pamoate [vandf]

    48. Hms500m16

    49. Pyrantel Pamoate Sigmaultra,(s)

    50. Amy3564

    51. Dtxsid40897057

    52. Pyrantel Embonate [mart.]

    53. Pyrantel Pamoate [usp-rs]

    54. Hms1920n06

    55. Hms2090j21

    56. Hms2092e07

    57. Pharmakon1600-01500517

    58. Pyrantel Embonate [who-dd]

    59. Pyrantel Embonate [who-ip]

    60. Ccg-39242

    61. Mfcd00072037

    62. Nsc757303

    63. S2501

    64. Stl481883

    65. Pyrantel Pamoate [green Book]

    66. Akos015908224

    67. Cs-3869

    68. Nsc-757303

    69. Idi1_000254

    70. Pyrantel Embonate [ep Monograph]

    71. Pyrantel Pamoate [usp Monograph]

    72. Ncgc00094552-01

    73. Ncgc00094552-02

    74. Ncgc00094552-03

    75. Pyranteli Embonas [who-ip Latin]

    76. 2-naphthoic Acid, 4,4'-methylenebis(3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)

    77. 4,4'-methylenebis(3-hydroxy-2-naphthoic) Acid, Compound With (e)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)

    78. Ac-24204

    79. As-12185

    80. Bp166202

    81. Hy-12640

    82. Sbi-0051499.p003

    83. C07389

    84. D00486

    85. F21340

    86. 204p246

    87. A816013

    88. Sr-05000001708

    89. Q3489331

    90. Sr-05000001708-1

    91. Pyrantel Pamoate, Vetranal(tm), Analytical Standard

    92. (e)-1-methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6

    93. Pyrantel Embonate, European Pharmacopoeia (ep) Reference Standard

    94. Pyrantel Pamoate, United States Pharmacopeia (usp) Reference Standard

    95. Pyrimidine,1,4,5,6-tetrahydro-1-methyl-2-[(1e)-2-(2-thienyl)ethenyl]-

    96. (e)-1,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine 4,4'-methylenebis[3-hydroxy-2-naphthoate] (1:1)

    97. 2-naphthalenecarboxylic Acid,4'-methylenebis[3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine (1:1)

    98. 2-naphthoic Acid,4'-methylenebis[3-hydroxy-, Compd. With (e)-1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine (1:1)

    99. 4,4'-methanediylbis(3-hydroxynaphthalene-2-carboxylic Acid) - 1-methyl-2-[(e)-2-(thiophen-2-yl)ethenyl]-1,4,5,6-tetrahydropyrimidine (1:1)

    100. 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic Acid,1-methyl-2-[(e)-2-thiophen-2-ylethenyl]-5,6-dihydro-4h-pyrimidine

    101. Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(-2-thienyl)ethenyl-, (e)-, With 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 594.7 g/mol
    Molecular Formula C34H30N2O6S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count6
    Exact Mass594.18245785 g/mol
    Monoisotopic Mass594.18245785 g/mol
    Topological Polar Surface Area159 Ų
    Heavy Atom Count43
    Formal Charge0
    Complexity816
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antinematodal Agents

    Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)

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    07-Jan-2022
    05-Apr-2025
    KGS
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    ABOUT THIS PAGE

    Looking for 22204-24-6 / Pyrantel Pamoate API manufacturers, exporters & distributors?

    Pyrantel Pamoate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Pyrantel Pamoate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pyrantel Pamoate manufacturer or Pyrantel Pamoate supplier for your needs.

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    PharmaCompass also assists you with knowing the Pyrantel Pamoate API Price utilized in the formulation of products. Pyrantel Pamoate API Price is not always fixed or binding as the Pyrantel Pamoate Price is obtained through a variety of data sources. The Pyrantel Pamoate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Pyrantel Pamoate

    Synonyms

    22204-24-6, Pyrantel embonate, Antiminth, Combantrin, Pyrantel (pamoate), Cp-10,423-16

    Cas Number

    22204-24-6

    Unique Ingredient Identifier (UNII)

    81BK194Z5M

    About Pyrantel Pamoate

    Broad spectrum antinematodal anthelmintic used also in veterinary medicine.

    Combantrin Manufacturers

    A Combantrin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Combantrin, including repackagers and relabelers. The FDA regulates Combantrin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Combantrin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Combantrin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Combantrin Suppliers

    A Combantrin supplier is an individual or a company that provides Combantrin active pharmaceutical ingredient (API) or Combantrin finished formulations upon request. The Combantrin suppliers may include Combantrin API manufacturers, exporters, distributors and traders.

    click here to find a list of Combantrin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Combantrin USDMF

    A Combantrin DMF (Drug Master File) is a document detailing the whole manufacturing process of Combantrin active pharmaceutical ingredient (API) in detail. Different forms of Combantrin DMFs exist exist since differing nations have different regulations, such as Combantrin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Combantrin DMF submitted to regulatory agencies in the US is known as a USDMF. Combantrin USDMF includes data on Combantrin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Combantrin USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Combantrin suppliers with USDMF on PharmaCompass.

    Combantrin JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Combantrin Drug Master File in Japan (Combantrin JDMF) empowers Combantrin API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Combantrin JDMF during the approval evaluation for pharmaceutical products. At the time of Combantrin JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Combantrin suppliers with JDMF on PharmaCompass.

    Combantrin CEP

    A Combantrin CEP of the European Pharmacopoeia monograph is often referred to as a Combantrin Certificate of Suitability (COS). The purpose of a Combantrin CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Combantrin EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Combantrin to their clients by showing that a Combantrin CEP has been issued for it. The manufacturer submits a Combantrin CEP (COS) as part of the market authorization procedure, and it takes on the role of a Combantrin CEP holder for the record. Additionally, the data presented in the Combantrin CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Combantrin DMF.

    A Combantrin CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Combantrin CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Combantrin suppliers with CEP (COS) on PharmaCompass.

    Combantrin WC

    A Combantrin written confirmation (Combantrin WC) is an official document issued by a regulatory agency to a Combantrin manufacturer, verifying that the manufacturing facility of a Combantrin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Combantrin APIs or Combantrin finished pharmaceutical products to another nation, regulatory agencies frequently require a Combantrin WC (written confirmation) as part of the regulatory process.

    click here to find a list of Combantrin suppliers with Written Confirmation (WC) on PharmaCompass.

    Combantrin NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Combantrin as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Combantrin API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Combantrin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Combantrin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Combantrin NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Combantrin suppliers with NDC on PharmaCompass.

    Combantrin GMP

    Combantrin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Combantrin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Combantrin GMP manufacturer or Combantrin GMP API supplier for your needs.

    Combantrin CoA

    A Combantrin CoA (Certificate of Analysis) is a formal document that attests to Combantrin's compliance with Combantrin specifications and serves as a tool for batch-level quality control.

    Combantrin CoA mostly includes findings from lab analyses of a specific batch. For each Combantrin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Combantrin may be tested according to a variety of international standards, such as European Pharmacopoeia (Combantrin EP), Combantrin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Combantrin USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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