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COLESTIPOL HYDROCHLORIDE
Also known as: Colestid, Cholestabyl, 37296-80-3, Colestipol hydrochloride [usan:usp], Lestid, Flavored colestid
Molecular Formula
C8H24ClN5
Molecular Weight
225.76  g/mol
InChI Key
GACQNVJDWUAPFY-UHFFFAOYSA-N

Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.
1 2D Structure

COLESTIPOL HYDROCHLORIDE

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;hydrochloride
2.1.2 InChI
InChI=1S/C8H23N5.ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;/h11-13H,1-10H2;1H
2.1.3 InChI Key
GACQNVJDWUAPFY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CNCCNCCNCCN)N.Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Colestid

2. Colestipol

3. Colestipol Hcl

4. Hcl, Colestipol

5. Hydrochloride, Colestipol

6. U 26,597 A

7. U-26,597 A

8. U26,597 A

2.2.2 Depositor-Supplied Synonyms

1. Colestid

2. Cholestabyl

3. 37296-80-3

4. Colestipol Hydrochloride [usan:usp]

5. Lestid

6. Flavored Colestid

7. N'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;hydrochloride

8. U-26597a

9. Unii-x7d10k905g

10. Tetraethylenepentamine Hcl

11. Copolymer Of Diethylenetriamine And 1-chloro-2,3-epoxypropane, Hydrochloride (with Approximately 1 Out Of 5 Amine Nitrogens Protonated)

12. Schembl284758

13. Dtxsid40190737

14. X7d10k905g

15. Ft-0749664

2.3 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 225.76 g/mol
Molecular Formula C8H24ClN5
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass225.1720235 g/mol
Monoisotopic Mass225.1720235 g/mol
Topological Polar Surface Area88.1 Ų
Heavy Atom Count14
Formal Charge0
Complexity78.6
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameColestipol hydrochloride
Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
Active IngredientColestipol hydrochloride
Dosage FormTablet; Granule
RouteOral
Strength1gm; 5gm/scoopful; 5gm/packet
Market StatusPrescription
CompanyImpax Labs

2 of 4  
Drug NameFlavored colestid
Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
Active IngredientColestipol hydrochloride
Dosage FormGranule
RouteOral
Strength5gm/scoopful; 5gm/packet
Market StatusPrescription
CompanyPharmacia And Upjohn

3 of 4  
Drug NameColestipol hydrochloride
Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
Active IngredientColestipol hydrochloride
Dosage FormTablet; Granule
RouteOral
Strength1gm; 5gm/scoopful; 5gm/packet
Market StatusPrescription
CompanyImpax Labs

4 of 4  
Drug NameFlavored colestid
Drug LabelCOLESTID Granules and FLAVORED COLESTID Granules contain colestipol hydrochloride, which is a lipid lowering agent for oral use. Colestipol hydrochloride is an insoluble, high molecular weight basic anion-exchange copolymer of diethylenetriamine and...
Active IngredientColestipol hydrochloride
Dosage FormGranule
RouteOral
Strength5gm/scoopful; 5gm/packet
Market StatusPrescription
CompanyPharmacia And Upjohn

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anion Exchange Resins

High-molecular-weight insoluble polymers that contain functional cationic groups capable of undergoing exchange reactions with anions. (See all compounds classified as Anion Exchange Resins.)


Hypolipidemic Agents

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)


Sequestering Agents

Compounds that bind to and reduce the biological availability of a chemical or pharmaceutical agent. (See all compounds classified as Sequestering Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Bile-acid Binding Activity [MoA]; Bile Acid Sequestrant [EPC]
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  • GRANULE;ORAL - 5GM/PACKET
  • TABLET;ORAL - 1GM
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