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Chemistry

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Also known as: Rize, Trecalmo, Rizen, Tienor, Rise, 33671-46-4
Molecular Formula
C16H15ClN2OS
Molecular Weight
318.8  g/mol
InChI Key
CHBRHODLKOZEPZ-UHFFFAOYSA-N
FDA UNII
ZCN055599V

Clotiazepam
Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
1 2D Structure

Clotiazepam

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
2.1.2 InChI
InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
2.1.3 InChI Key
CHBRHODLKOZEPZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC1=CC2=C(S1)N(C(=O)CN=C2C3=CC=CC=C3Cl)C
2.2 Other Identifiers
2.2.1 UNII
ZCN055599V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Y 6047

2. Y-6047

3. Y6047

2.3.2 Depositor-Supplied Synonyms

1. Rize

2. Trecalmo

3. Rizen

4. Tienor

5. Rise

6. 33671-46-4

7. Clotiazepamum [inn-latin]

8. Y 6047

9. 5-(2-chlorophenyl)-7-ethyl-1-methyl-3h-thieno[2,3-e][1,4]diazepin-2-one

10. 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2h-thieno(2,3-e)-1,4-diazepin-2-one

11. 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno(2,3-e)(1,4)diazepin-2-one

12. Zcn055599v

13. 2h-thieno(2,3e)(1,4)-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

14. 5-(2-chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2h-thieno[2,3-e][1,4]diazepin-2-one

15. Clotiazepamum

16. Distensan

17. Veratran

18. Clozan

19. Clotiazepam [inn:jan]

20. 2h-thieno(2,3-e)(1,4)diazepin-2-one, 1,3-dihydro-5-(o-chlorophenyl)-7-ethyl-1-methyl-

21. 2h-thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

22. Rize (tn)

23. Einecs 251-627-3

24. Brn 0623332

25. Unii-zcn055599v

26. Dea No. 2752

27. Y-6047

28. Clotiazepam [mi]

29. Clotiazepam [inn]

30. Clotiazepam [jan]

31. Clotiazepam (jp17/inn)

32. Clotiazepam [mart.]

33. Schembl44592

34. Clotiazepam [who-dd]

35. Zinc1207

36. Chembl1697737

37. Dtxsid0022852

38. Chebi:31425

39. Hy-u00317

40. Akos005065735

41. Cs-7319

42. Db01559

43. D01328

44. Q2263999

45. 2h-thieno[2,3-e]-1,4-diazepine-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-

46. 5-(2-chlorophenyl)-7-ethyl-1-methyl-1h,2h,3h-thieno[2,3-e][1,4]diazepin-2-one

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 318.8 g/mol
Molecular Formula C16H15ClN2OS
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass318.0593620 g/mol
Monoisotopic Mass318.0593620 g/mol
Topological Polar Surface Area60.9 Ų
Heavy Atom Count21
Formal Charge0
Complexity442
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of anxiety disorders.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It increases the stage 2 non-rapid eye movement sleep.


5.2 ATC Code

N05BA21

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N05 - Psycholeptics

N05B - Anxiolytics

N05BA - Benzodiazepine derivatives

N05BA21 - Clotiazepam


5.3 Metabolism/Metabolites

Hepatic.


Clotiazepam has known human metabolites that include Hydroxy-clotiazepam and desmethyl-clotiazepam.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.4 Biological Half-Life

4 hours


5.5 Mechanism of Action

Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons.


API SUPPLIERS

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01

Centaur Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Centaur Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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02

Samhwa Biopharm

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

The MedTech Conference
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Samhwa Biopharm

South Korea

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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03

R L Fine Chem

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

The MedTech Conference
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R L Fine Chem

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Listed Suppliers

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PackExpo
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Clotiazepam

About the Company : Centaur accepts change as a constant, and continuously innovates to remain significant. Centaur has built knowledge sharing relationships with the pharmaceutical majors in areas of...

Centaur accepts change as a constant, and continuously innovates to remain significant. Centaur has built knowledge sharing relationships with the pharmaceutical majors in areas of product development, custom synthesis, contract research and contract manufacturing. Centaur formulations and API are exported across 5 continents and more than 60 countries including regulated markets. Centaur ranks among India's TOP 50 pharmaceutical companies by prescriptions (CMarc) and by stockist audit (ORG-IMS). Centaur's All-India network includes a 1000 strong sales force that covers 250,000 doctors and 250,000 retailers every month.
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02

PackExpo
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PackExpo
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Clotiazepam

About the Company : Established in 1984, R L Fine Chem Pvt. Ltd. is one of the fastest growing API companies, with a leadership position in several APIs such as antihistamines, antidepressants and mus...

Established in 1984, R L Fine Chem Pvt. Ltd. is one of the fastest growing API companies, with a leadership position in several APIs such as antihistamines, antidepressants and muscle relaxants. Acquired by private equity groups in 2016, it is one of India’s leading manufacturers of psychotropic substances. It supplies over 60 APIs to customers in more than 62 countries from FDA and EU-approved locations. R L Fine Chem is a technology-driven company with a focus on the in-house manufacture of key intermediates for our APIs. The company currently operates out of four facilities in the Indian states of Karnataka and Andhra Pradesh.
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03

Samhwa Biopharm

South Korea
PackExpo
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Samhwa Biopharm

South Korea
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PackExpo
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Clotiazepam

About the Company : Samhwa Biopharm Co., Ltd. is a South Korean pharmaceutical company specializing in the development and production of active pharmaceutical ingredients (APIs), excipients, and inter...

Samhwa Biopharm Co., Ltd. is a South Korean pharmaceutical company specializing in the development and production of active pharmaceutical ingredients (APIs), excipients, and intermediates. With a portfolio encompassing over 30 products, Samhwa Biopharm serves global markets, including Russia, Vietnam, and Colombia. The company operates manufacturing facilities in Gyeonggi-do, South Korea, and maintains a robust supply chain with partners in India. Samhwa Biopharm is committed to delivering high-quality pharmaceutical solutions to meet diverse therapeutic needs worldwide.
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API Reference Price

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19-Jan-2022
02-Apr-2025
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Drugs in Development

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Details:

Clotiazepam is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.


Lead Product(s): Clotiazepam,Inapplicable

Therapeutic Area: Undisclosed Brand Name: Undisclosed

Study Phase: Phase IProduct Type: Miscellaneous

Sponsor: Undisclosed

Deal Size: Inapplicable Upfront Cash: Inapplicable

Deal Type: Inapplicable June 19, 2020

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01

Andromaco

Chile
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Luxepack
Not Confirmed

Andromaco

Chile
arrow
Luxepack
Not Confirmed

Details : Clotiazepam is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

Product Name : Undisclosed

Product Type : Miscellaneous

Upfront Cash : Inapplicable

June 19, 2020

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ABOUT THIS PAGE

Looking for 33671-46-4 / Clotiazepam API manufacturers, exporters & distributors?

Clotiazepam manufacturers, exporters & distributors 1

46

PharmaCompass offers a list of Clotiazepam API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Clotiazepam manufacturer or Clotiazepam supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Clotiazepam manufacturer or Clotiazepam supplier.

PharmaCompass also assists you with knowing the Clotiazepam API Price utilized in the formulation of products. Clotiazepam API Price is not always fixed or binding as the Clotiazepam Price is obtained through a variety of data sources. The Clotiazepam Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Clotiazepam

Synonyms

Rize, Trecalmo, Rizen, Tienor, Rise, 33671-46-4

Cas Number

33671-46-4

Unique Ingredient Identifier (UNII)

ZCN055599V

About Clotiazepam

Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.

Clotiazepam Manufacturers

A Clotiazepam manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Clotiazepam, including repackagers and relabelers. The FDA regulates Clotiazepam manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Clotiazepam API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Clotiazepam manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Clotiazepam Suppliers

A Clotiazepam supplier is an individual or a company that provides Clotiazepam active pharmaceutical ingredient (API) or Clotiazepam finished formulations upon request. The Clotiazepam suppliers may include Clotiazepam API manufacturers, exporters, distributors and traders.

click here to find a list of Clotiazepam suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Clotiazepam WC

A Clotiazepam written confirmation (Clotiazepam WC) is an official document issued by a regulatory agency to a Clotiazepam manufacturer, verifying that the manufacturing facility of a Clotiazepam active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Clotiazepam APIs or Clotiazepam finished pharmaceutical products to another nation, regulatory agencies frequently require a Clotiazepam WC (written confirmation) as part of the regulatory process.

click here to find a list of Clotiazepam suppliers with Written Confirmation (WC) on PharmaCompass.

Clotiazepam GMP

Clotiazepam Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Clotiazepam GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Clotiazepam GMP manufacturer or Clotiazepam GMP API supplier for your needs.

Clotiazepam CoA

A Clotiazepam CoA (Certificate of Analysis) is a formal document that attests to Clotiazepam's compliance with Clotiazepam specifications and serves as a tool for batch-level quality control.

Clotiazepam CoA mostly includes findings from lab analyses of a specific batch. For each Clotiazepam CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Clotiazepam may be tested according to a variety of international standards, such as European Pharmacopoeia (Clotiazepam EP), Clotiazepam JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Clotiazepam USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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