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Also known as: Citicoline sodium, 33818-15-4, Citicoline sodium salt, Cytidine 5'-diphosphocholine sodium, Cdp-choline sodium, Citicoline, sodium
Molecular Formula
C14H25N4NaO11P2
Molecular Weight
510.31  g/mol
InChI Key
YWAFNFGRBBBSPD-KDVMHAGBSA-M

Citicoline Sodium
1 2D Structure

Citicoline Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;[[(2S,3R,4S,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] 2-(trimethylazaniumyl)ethyl phosphate
2.1.2 InChI
InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m0./s1
2.1.3 InChI Key
YWAFNFGRBBBSPD-KDVMHAGBSA-M
2.1.4 Canonical SMILES
C[N+](C)(C)CCOP(=O)([O-])OP(=O)([O-])OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O.[Na+]
2.1.5 Isomeric SMILES
C[N+](C)(C)CCOP(=O)([O-])OP(=O)([O-])OC[C@H]1[C@@H]([C@@H]([C@H](O1)N2C=CC(=NC2=O)N)O)O.[Na+]
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. Citicoline Sodium

2. 33818-15-4

3. Citicoline Sodium Salt

4. Cytidine 5'-diphosphocholine Sodium

5. Cdp-choline Sodium

6. Citicoline, Sodium

7. Cdp-choline, Sodium

8. Cytidine 5'-diphosphocholine Sodium Salt

9. Cytidine 5'-diphosphocholine Sodium Salt Dihydrate

10. Cytidine-5'-diphosphocholine Monosodium Salt

11. A821952

12. Sodium [[(2s,3r,4s,5s)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl] 2-(trimethylammonio)ethyl Phosphate;citicoline Sodium Salt

2.3 Create Date
2010-07-26
3 Chemical and Physical Properties
Molecular Weight 510.31 g/mol
Molecular Formula C14H25N4NaO11P2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count10
Exact Mass510.08927590 g/mol
Monoisotopic Mass510.08927590 g/mol
Topological Polar Surface Area216 Ų
Heavy Atom Count32
Formal Charge0
Complexity813
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

API Reference Price

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11-Jan-2021
31-Mar-2025
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Looking for 33818-15-4 / Citicoline Sodium API manufacturers, exporters & distributors?

Citicoline Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Citicoline Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Citicoline Sodium manufacturer or Citicoline Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Citicoline Sodium manufacturer or Citicoline Sodium supplier.

PharmaCompass also assists you with knowing the Citicoline Sodium API Price utilized in the formulation of products. Citicoline Sodium API Price is not always fixed or binding as the Citicoline Sodium Price is obtained through a variety of data sources. The Citicoline Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Citicoline Sodium

Synonyms

33818-15-4, Citicoline sodium salt, Cytidine 5'-diphosphocholine sodium, Cdp-choline sodium, Citicoline, sodium, Cdp-choline, sodium

Cas Number

33818-15-4

Citicoline Manufacturers

A Citicoline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Citicoline, including repackagers and relabelers. The FDA regulates Citicoline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Citicoline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Citicoline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Citicoline Suppliers

A Citicoline supplier is an individual or a company that provides Citicoline active pharmaceutical ingredient (API) or Citicoline finished formulations upon request. The Citicoline suppliers may include Citicoline API manufacturers, exporters, distributors and traders.

click here to find a list of Citicoline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Citicoline USDMF

A Citicoline DMF (Drug Master File) is a document detailing the whole manufacturing process of Citicoline active pharmaceutical ingredient (API) in detail. Different forms of Citicoline DMFs exist exist since differing nations have different regulations, such as Citicoline USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Citicoline DMF submitted to regulatory agencies in the US is known as a USDMF. Citicoline USDMF includes data on Citicoline's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Citicoline USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Citicoline suppliers with USDMF on PharmaCompass.

Citicoline JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Citicoline Drug Master File in Japan (Citicoline JDMF) empowers Citicoline API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Citicoline JDMF during the approval evaluation for pharmaceutical products. At the time of Citicoline JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Citicoline suppliers with JDMF on PharmaCompass.

Citicoline KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Citicoline Drug Master File in Korea (Citicoline KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Citicoline. The MFDS reviews the Citicoline KDMF as part of the drug registration process and uses the information provided in the Citicoline KDMF to evaluate the safety and efficacy of the drug.

After submitting a Citicoline KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Citicoline API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Citicoline suppliers with KDMF on PharmaCompass.

Citicoline WC

A Citicoline written confirmation (Citicoline WC) is an official document issued by a regulatory agency to a Citicoline manufacturer, verifying that the manufacturing facility of a Citicoline active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Citicoline APIs or Citicoline finished pharmaceutical products to another nation, regulatory agencies frequently require a Citicoline WC (written confirmation) as part of the regulatory process.

click here to find a list of Citicoline suppliers with Written Confirmation (WC) on PharmaCompass.

Citicoline GMP

Citicoline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Citicoline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Citicoline GMP manufacturer or Citicoline GMP API supplier for your needs.

Citicoline CoA

A Citicoline CoA (Certificate of Analysis) is a formal document that attests to Citicoline's compliance with Citicoline specifications and serves as a tool for batch-level quality control.

Citicoline CoA mostly includes findings from lab analyses of a specific batch. For each Citicoline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Citicoline may be tested according to a variety of international standards, such as European Pharmacopoeia (Citicoline EP), Citicoline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Citicoline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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