X
API Suppliers
US DMFs Filed
CEP/COS Certifications
0
JDMFs Filed
0
EU WC
Listed Suppliers
0
USA (Orange Book)
0
Europe
0
Canada
0
Australia
0
South Africa
0
Uploaded Dossiers
0
U.S. Medicaid
0
Annual Reports
0
USFDA Orange Book Patents
0
USFDA Exclusivities
0
Blog #PharmaFlow
0
News
0
EDQM
0
USP
0
JP
0
Other Listed Suppliers
0
0
1. Mundasal
2. Mundisal
1. 2016-36-6
2. Syrap
3. (2-hydroxyethyl)trimethylammonium Salicylate
4. Choline Salicylic Acid Salt
5. Salicylic Acid Choline Salt
6. Choline, Salicylate (salt)
7. Cholin Salicylate
8. Salicylic Acid, Ion(1-), Choline
9. Choline Subsalicylate
10. 2-hydroxy-n,n,n-trimethylethanaminium 2-hydroxybenzoate
11. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, Salt With 2-hydroxybenzoic Acid (1:1)
12. Kd510k1iqw
13. Arthropan
14. 2-hydroxy-n,n,n-trimethylethanaminium Salt With 2-hydroxybenzoic Acid (1:1)
15. Actasal
16. Artrobione
17. Mundisal
18. Salicol
19. Satibon
20. Arret
21. 2-hydroxybenzoate;2-hydroxyethyl(trimethyl)azanium
22. 2-carboxyphenolate;2-hydroxyethyl(trimethyl)azanium
23. Choline Salicylate B
24. Cholinesalicylate
25. Ethanaminium, 2-hydroxy-n,n,n-trimethyl-, 2-hydroxybenzoate (1:1)
26. Cholini Salicylas
27. Salicilato De Colina
28. Cholini Salicylas [inn-latin]
29. Salicylate De Choline
30. Salicilato De Colina [inn-spanish]
31. Salicylate De Choline [inn-french]
32. Einecs 217-948-8
33. Unii-kd510k1iqw
34. Choline Salicylate [usan:inn:ban:jan]
35. Arthropan (tn)
36. Choline Salicylate (salt)
37. Schembl3960
38. Chebi:3668
39. Choline Salicylate [mi]
40. Chembl2104095
41. Choline Salicylate [inn]
42. Choline Salicylate [jan]
43. Dtxsid8062103
44. Choline Salicylate [usan]
45. Choline Salicylate [vandf]
46. Choline Salicylate [mart.]
47. Choline Salicylate [who-dd]
48. Choline Salicylate (jan/usan/inn)
49. Mfcd00242760
50. Akos030228339
51. Db14006
52. As-66082
53. Cs-0449641
54. D00810
55. (2-hydroxyethyl)trimethylazanium 2-hydroxybenzoate
56. A909239
57. (2-hydroxyethyl)trimethyl Ammonium Salicylate
58. 2-carboxyphenolate,2-hydroxyethyl(trimethyl)azanium
59. Q4499058
60. (2-hydroxyethyl)trimethylammonium 2-hydroxybenzoate
61. 2-hydroxy-n,n,n-trimethylethan-1-aminium 2-hydroxybenzoate
62. 2-hydroxy-n,n,n-trimethylethan-1-aminium 2-carboxyphenolate
63. Benzoic Acid, 2-hydroxy-, Ion(1-), 2-hydroxy-n,n,n-trimethylethanaminium
| Molecular Weight | 241.28 g/mol |
|---|---|
| Molecular Formula | C12H19NO4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 241.13140809 g/mol |
| Monoisotopic Mass | 241.13140809 g/mol |
| Topological Polar Surface Area | 80.6 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 179 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due to orthodontic devices in children.
This is an anti-inflammatory and antipyretic medication,. If is often used in oral gel form for the relief of pain, discomfort, and inflammation caused by common mouth ulcers, cold sores, denture and sore spots, as well as mouth ulcers, and sore spots because of orthodontic devices.
N - Nervous system
N02 - Analgesics
N02B - Other analgesics and antipyretics
N02BA - Salicylic acid and derivatives
N02BA03 - Choline salicylate
Absorption
Onset: 1-2 hr after ingestion In the oral form, choline salicylate is absorbed across the buccal mucosa. There is a need for caution not to exceed the stated dose and monitor for any signs of suggested salicylism, especially when this drug is used for infants. In one study, it was found that this drug was more rapidly absorbed than ASA (absorption t1/2 = 0.1 vs 0.36 h).
Route of Elimination
Both metabolites of choline salicylate, and a small amount of intact salicylic acid are excreted, primarily in the urine.
Volume of Distribution
0.15 L/kg (salicylate), and widely distributed throughout extracellular water and most tissues
The metabolism of salicylic acid is by glycine and phenolic or acyl glucuronate conjugation with small amounts of the drug undergoing hydroxylation. Extensively metabolized in the liver; inactive metabolites are excreted by the kidneys.
The plasma half-life of salicylic acid is 2-4 hours. Up to 15 30 h with larger doses due to saturation of liver metabolism capacity.
Choline salicylate relieves pain by inhibition of prostaglandin synthesis and reduces fever by acting on the hypothalamus heat-regulating center. It also inhibits the generation of impulses through the inhibition of cyclooxygenase enzyme (COX),. Cyclooxygenase is involved in the production of prostaglandins, in response to injury and after various other stimuli. The prostaglandins promote pain, swelling, and inflammation. The choline salicylate decreases inflammation and pain by reducing the production of these prostaglandins in the area of the mouth it is applied to.
Market Place
