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Chantix

Chantix

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

40 API Suppliers, 20 USDMF, 1 JDMF, 8 EU WC, 9 KDMF, 11 NDC API, 27 Listed Suppliers

DEVELOPMENTS

17 Drug(s) in Development

17 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports

INTERMEDIATES

10 Suppliers

10 Suppliers

DOSSIERs // Finished Dosage Formulations

76 Dossiers, 29 FDA Orange Book, 17 Europe, 6 Canada, 9 Australia, 5 South Africa, 10 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET;ORAL - EQ 0.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, TABLET;ORAL - EQ 1MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

TABLET;ORAL - EQ 0.5MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
TABLET;ORAL - EQ 1MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers, 15 Kerry, 10 Corel Pharma Chem, 10 Roquette, 9 BASF, 9 Sigachi Industries, 8 Microlex e.U, 7 Gangwal Chemicals, 6 Lonza Capsugel, 6 Gangwal Healthcare, 6 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Seppic, 5 Ideal Cures Pvt Ltd, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 3 DFE Pharma, 3 Kima Chemical, 3 Vasa Pharmachem, 3 Prachin Chemical, 3 Actylis, 2 Seqens, 2 Nomisma Healthcare, 2 The Dow Chemical Company, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Pharmatrans-Sanaq, 1 Finar, 1 Jai Radhe Sales, 1 Ingredion Pharma Solutions, 1 ACG Worldwide, 1 Qualicaps, 1 SPI Pharma

EXCIPIENTS BY APPLICATIONS

41 Coating Systems & Additives, 25 Fillers, Diluents & Binders, 24 Controlled & Modified Release, 16 Disintegrants & Superdisintegrants, 15 Thickeners and Stabilizers, 13 Direct Compression, 11 Lubricants & Glidants, 10 Granulation, 8 Film Formers & Plasticizers, 7 Topical, 6 Co-Processed Excipients, 5 Empty Capsules, 5 Solubilizers, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Taste Masking, 3 Emulsifying Agents, 3 Rheology Modifiers, 3 Chewable & Orodispersible Aids, 2 Parenteral, 2 Coloring Agents

GLOBAL SALES INFORMATION

9 US Medicaid Prescriptions, 14 Finished Drug Prices

MARKET PLACE

12 APIs, 2 DOSSIERS // FDF

PATENTS

6 US Patents, 1 US Exclusivities, 9 Health Canada Patents

ANALYTICAL SOLUTION(s)

6 Other Ref. Standards

6 Other Ref. Standards

DIGITAL CONTENT

3 Data Compilations & Company Tracker #PharmaFlow, 69 News

Product Search

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

Other Certificates

Other Suppliers

API REF. PRICE (USD / KG)

52,730

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

1,610.00

Annual Reports

1,084.00

FDF Market Place

EXCIPIENTS

130

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Varenicline tartrate, 375815-87-5, (2s,3s)-2,3-dihydroxybutanedioic acid; 5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2(11),3,5,7,9-pentaene, (2s,3s)-2,3-dihydroxybutanedioic acid;5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene, Akos026750167, As-35136

Molecular Formula

C₁₇H₁₉N₃O₆

Molecular Weight

361.3 g/mol

InChI Key

TWYFGYXQSYOKLK-WUUYCOTASA-N

A benzazepine derivative that functions as an ALPHA4-BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.

1 2D Structure

Chantix

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3S)-2,3-dihydroxybutanedioic acid;5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene

2.1.2 InChI

InChI=1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.0/s1

2.1.3 InChI Key

TWYFGYXQSYOKLK-WUUYCOTASA-N

2.1.4 Canonical SMILES

C1C2CNCC1C3=CC4=NC=CN=C4C=C23.C(C(C(=O)O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

C1C2CNCC1C3=CC4=NC=CN=C4C=C23.[C@H]([C@@H](C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 6,7,8,9-tetrahydro-6,10-methano-6h-pyrazino(2,3-h)benzazepine

2. Champix

3. Varenicline

4. Varenicline Tartrate

2.2.2 Depositor-Supplied Synonyms

1. Varenicline Tartrate

2. 375815-87-5

3. (2s,3s)-2,3-dihydroxybutanedioic Acid; 5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2(11),3,5,7,9-pentaene

4. (2s,3s)-2,3-dihydroxybutanedioic Acid;5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene

5. Akos026750167

6. As-35136

7. A21286

8. Z1642292115

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₁₉N₃O₆
Molecular Weight	361.3 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	361.12738533 g/mol
Monoisotopic Mass	361.12738533 g/mol
Topological Polar Surface Area	153 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	388
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Chantix
PubMed Health	Varenicline (By mouth)
Drug Classes	Smoking Ceation Agent
Drug Label	CHANTIX tablets contain varenicline (as the tartrate salt), which is a partial agonist selective for 42 nicotinic acetylcholine receptor subtypes.Varenicline, as the tartrate salt, is a powder which is a white to off-white to slightly yellow soli...
Active Ingredient	Varenicline tartrate
Dosage Form	Tablet
Route	Oral
Strength	eq 0.5mg base; eq 1mg base
Market Status	Prescription
Company	Pfizer

2 of 2
Drug Name	Chantix
PubMed Health	Varenicline (By mouth)
Drug Classes	Smoking Ceation Agent
Drug Label	CHANTIX tablets contain varenicline (as the tartrate salt), which is a partial agonist selective for 42 nicotinic acetylcholine receptor subtypes.Varenicline, as the tartrate salt, is a powder which is a white to off-white to slightly yellow soli...
Active Ingredient	Varenicline tartrate
Dosage Form	Tablet
Route	Oral
Strength	eq 0.5mg base; eq 1mg base
Market Status	Prescription
Company	Pfizer

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Nicotinic Agonists

Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission. (See all compounds classified as Nicotinic Agonists.)

Smoking Cessation Agents

Substances that facilitate the cessation of tobacco smoking. (See all compounds classified as Smoking Cessation Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Partial Cholinergic Nicotinic Agonists [MoA]; Partial Cholinergic Nicotinic Agonist [EPC]