Find CG200745 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Cg-200745, 936221-33-9, Cg200745, Cg-2, Hdcg-0745, 4i8mlm7l2h
Molecular Formula
C24H33N3O4
Molecular Weight
427.5  g/mol
InChI Key
AUGCSOFQTDKPSO-RGVLZGJSSA-N
FDA UNII
4I8MLM7L2H

CG200745
Ivaltinostat is a histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Ivaltinosta tinhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.
1 2D Structure

CG200745

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-N-[3-(dimethylamino)propyl]-N'-hydroxy-2-(naphthalen-1-yloxymethyl)oct-2-enediamide
2.1.2 InChI
InChI=1S/C24H33N3O4/c1-27(2)17-9-16-25-24(29)20(11-4-3-5-15-23(28)26-30)18-31-22-14-8-12-19-10-6-7-13-21(19)22/h6-8,10-14,30H,3-5,9,15-18H2,1-2H3,(H,25,29)(H,26,28)/b20-11+
2.1.3 InChI Key
AUGCSOFQTDKPSO-RGVLZGJSSA-N
2.1.4 Canonical SMILES
CN(C)CCCNC(=O)C(=CCCCCC(=O)NO)COC1=CC=CC2=CC=CC=C21
2.1.5 Isomeric SMILES
CN(C)CCCNC(=O)/C(=C/CCCCC(=O)NO)/COC1=CC=CC2=CC=CC=C21
2.2 Other Identifiers
2.2.1 UNII
4I8MLM7L2H
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cg200745

2. N1-(3-(dimethylamino)propyl)-n8-hydroxy-2-((naphthalene-1-loxy)methyl)oct-2-enediamide

2.3.2 Depositor-Supplied Synonyms

1. Cg-200745

2. 936221-33-9

3. Cg200745

4. Cg-2

5. Hdcg-0745

6. 4i8mlm7l2h

7. Cg 2 (hdac Inhibitor)

8. J3.106.463e

9. (e)-n-(3-(dimethylamino)propyl)-n'-hydroxy-2-((1-naphthyloxy)methyl)-2-octenediamide

10. (e)-n1-(3-(dimethylamino)propyl)-n8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide

11. 2-octenediamide, N1-(3-(dimethylamino)propyl)-n8-hydroxy-2-((1-naphthalenyloxy)methyl)-, (2e)-

12. 3-[(1r,3s,5s)-3-({7-[(5-methyl-1h-pyrazol-3-yl)amino]-1,6-naphthyridin-5-yl}amino)8-azabicyclo[3.2.1]octan-8-yl]propanenitrile

13. (e)-n-[3-(dimethylamino)propyl]-n'-hydroxy-2-(naphthalen-1-yloxymethyl)oct-2-enediamide

14. Ivaltinostat [inn]

15. Unii-4i8mlm7l2h

16. Chembl4297366

17. Schembl16166645

18. Schembl16166647

19. Gtpl10055

20. Dtxsid801028069

21. Db12259

22. Hy-16138

23. Cs-0006157

24. Q27259620

25. (e)-n-(3-dimethylaminopropyl)-n'-hydroxy-2-(naphthalen-1-yloxymethyl)oct-2-enediamide

2.4 Create Date
2007-06-19
3 Chemical and Physical Properties
Molecular Weight 427.5 g/mol
Molecular Formula C24H33N3O4
XLogP33
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count13
Exact Mass427.24710654 g/mol
Monoisotopic Mass427.24710654 g/mol
Topological Polar Surface Area90.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity579
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 936221-33-9 / CG200745 API manufacturers, exporters & distributors?

CG200745 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of CG200745 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CG200745 manufacturer or CG200745 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CG200745 manufacturer or CG200745 supplier.

PharmaCompass also assists you with knowing the CG200745 API Price utilized in the formulation of products. CG200745 API Price is not always fixed or binding as the CG200745 Price is obtained through a variety of data sources. The CG200745 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CG200745

Synonyms

Cg-200745, 936221-33-9, Cg-2, Hdcg-0745, 4i8mlm7l2h, Cg 2 (hdac inhibitor)

Cas Number

936221-33-9

Unique Ingredient Identifier (UNII)

4I8MLM7L2H

About CG200745

Ivaltinostat is a histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Ivaltinosta tinhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.

CG200745 Manufacturers

A CG200745 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CG200745, including repackagers and relabelers. The FDA regulates CG200745 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CG200745 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CG200745 Suppliers

A CG200745 supplier is an individual or a company that provides CG200745 active pharmaceutical ingredient (API) or CG200745 finished formulations upon request. The CG200745 suppliers may include CG200745 API manufacturers, exporters, distributors and traders.

CG200745 GMP

CG200745 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CG200745 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CG200745 GMP manufacturer or CG200745 GMP API supplier for your needs.

CG200745 CoA

A CG200745 CoA (Certificate of Analysis) is a formal document that attests to CG200745's compliance with CG200745 specifications and serves as a tool for batch-level quality control.

CG200745 CoA mostly includes findings from lab analyses of a specific batch. For each CG200745 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CG200745 may be tested according to a variety of international standards, such as European Pharmacopoeia (CG200745 EP), CG200745 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CG200745 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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