Find CFI-402257 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Cfi-402257, 1610759-22-2, He97ptk3q6, Cid 118086034, Chembl4442392, Chembl4469414
Molecular Formula
C28H30N6O3
Molecular Weight
498.6  g/mol
InChI Key
PMQUGSPFUBGJCZ-UHFFFAOYSA-N
FDA UNII
HE97PTK3Q6

CFI-402257
Threonine Tyrosine Kinase Inhibitor CFI-402257 is an orally bioavailable, selective inhibitor of the dual specificity protein kinase TTK (monopolar spindle 1 kinase, Mps1), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor CFI-402257 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC) and accelerates mitosis, which results in chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells. Mps1, a tyrosine and serine/threonine kinase expressed in proliferating normal tissues, is essential for proper SAC functioning and chromosome alignment. Overexpressed in various human tumors, Mps1 plays a key role in uncontrolled tumor cell growth.
1 2D Structure

CFI-402257

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-cyclopropyl-4-[7-[(3-hydroxy-3-methylcyclobutyl)methylamino]-5-pyridin-3-yloxypyrazolo[1,5-a]pyrimidin-3-yl]-2-methylbenzamide
2.1.2 InChI
InChI=1S/C28H30N6O3/c1-17-10-19(5-8-22(17)27(35)32-20-6-7-20)23-16-31-34-24(30-14-18-12-28(2,36)13-18)11-25(33-26(23)34)37-21-4-3-9-29-15-21/h3-5,8-11,15-16,18,20,30,36H,6-7,12-14H2,1-2H3,(H,32,35)
2.1.3 InChI Key
PMQUGSPFUBGJCZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=CC(=C1)C2=C3N=C(C=C(N3N=C2)NCC4CC(C4)(C)O)OC5=CN=CC=C5)C(=O)NC6CC6
2.2 Other Identifiers
2.2.1 UNII
HE97PTK3Q6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cfi-402257

2.3.2 Depositor-Supplied Synonyms

1. Cfi-402257

2. 1610759-22-2

3. He97ptk3q6

4. Cid 118086034

5. Chembl4442392

6. Chembl4469414

7. Cfi402257

8. Cfi 402257

9. Benzamide, N-cyclopropyl-4-(7-(((cis-3-hydroxy-3-methylcyclobutyl)methyl)amino)-5-(3-pyridinyloxy)pyrazolo(1,5-a)pyrimidin-3-yl)-2-methyl-

10. N-cyclopropyl-4-(7-(((cis-3-hydroxy-3-methylcyclobutyl)methyl)amino)-5-(3-pyridinyloxy)pyrazolo(1,5-a)pyrimidin-3-yl)-2-methylbenzamide

11. Luvixasertib

12. Unii-he97ptk3q6

13. Schembl16729234

14. Schembl17182976

15. Schembl17190272

16. Schembl22046104

17. Schembl22875551

18. Gtpl11664

19. Bcp31204

20. Ex-a2577

21. Bdbm50512456

22. Bdbm50533120

23. Nsc800888

24. Zinc669678971

25. Cs-6527

26. Nsc-800888

27. Sb19839

28. Compound 24 [pmid: 27437075]

29. Ac-36155

30. Hy-101340

31. Cfi 402257; Cfi402257

32. J3.619.525h

33. A906482

34. 1610677-37-6

35. N-cyclopropyl-4-(7-((((1r,3r)-3-hydroxy-3-methylcyclobutyl)methyl)amino)-5-(pyridin-3-yloxy)pyrazolo[1,5-a]pyrimidin-3-yl)-2-methylbenzamide

36. N-cyclopropyl-4-[7-[[(cis-3-hydroxy-3-methylcyclobutyl)methyl]amino]-5-(3-pyridinyloxy)pyrazolo[1,5-a]pyrimidin-3-yl]-2-methyl-benzamide

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 498.6 g/mol
Molecular Formula C28H30N6O3
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass498.23793884 g/mol
Monoisotopic Mass498.23793884 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count37
Formal Charge0
Complexity805
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1610759-22-2 / CFI-402257 API manufacturers, exporters & distributors?

CFI-402257 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of CFI-402257 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CFI-402257 manufacturer or CFI-402257 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CFI-402257 manufacturer or CFI-402257 supplier.

PharmaCompass also assists you with knowing the CFI-402257 API Price utilized in the formulation of products. CFI-402257 API Price is not always fixed or binding as the CFI-402257 Price is obtained through a variety of data sources. The CFI-402257 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CFI-402257

Synonyms

1610759-22-2, He97ptk3q6, Cid 118086034, Chembl4442392, Chembl4469414, Cfi402257

Cas Number

1610759-22-2

Unique Ingredient Identifier (UNII)

HE97PTK3Q6

About CFI-402257

Threonine Tyrosine Kinase Inhibitor CFI-402257 is an orally bioavailable, selective inhibitor of the dual specificity protein kinase TTK (monopolar spindle 1 kinase, Mps1), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor CFI-402257 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC) and accelerates mitosis, which results in chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells. Mps1, a tyrosine and serine/threonine kinase expressed in proliferating normal tissues, is essential for proper SAC functioning and chromosome alignment. Overexpressed in various human tumors, Mps1 plays a key role in uncontrolled tumor cell growth.

CFI 402257 Manufacturers

A CFI 402257 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CFI 402257, including repackagers and relabelers. The FDA regulates CFI 402257 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CFI 402257 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CFI 402257 Suppliers

A CFI 402257 supplier is an individual or a company that provides CFI 402257 active pharmaceutical ingredient (API) or CFI 402257 finished formulations upon request. The CFI 402257 suppliers may include CFI 402257 API manufacturers, exporters, distributors and traders.

CFI 402257 GMP

CFI 402257 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CFI 402257 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CFI 402257 GMP manufacturer or CFI 402257 GMP API supplier for your needs.

CFI 402257 CoA

A CFI 402257 CoA (Certificate of Analysis) is a formal document that attests to CFI 402257's compliance with CFI 402257 specifications and serves as a tool for batch-level quality control.

CFI 402257 CoA mostly includes findings from lab analyses of a specific batch. For each CFI 402257 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CFI 402257 may be tested according to a variety of international standards, such as European Pharmacopoeia (CFI 402257 EP), CFI 402257 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CFI 402257 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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