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Chemistry

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Also known as: Cfi-400945, 1338806-73-7, Cfi-400945 (free base), Tl1ud860aa, 1338806-76-0, 1616420-30-4
Molecular Formula
C33H34N4O3
Molecular Weight
534.6  g/mol
InChI Key
DADASRPKWOGKCU-FVTQAUBDSA-N
FDA UNII
TL1UD860AA

CFI-400945
PLK4 Inhibitor CFI-400945 is a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.
1 2D Structure

CFI-400945

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2'S,3R)-2'-[3-[(E)-2-[4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]ethenyl]-1H-indazol-6-yl]-5-methoxyspiro[1H-indole-3,1'-cyclopropane]-2-one
2.1.2 InChI
InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
2.1.3 InChI Key
DADASRPKWOGKCU-FVTQAUBDSA-N
2.1.4 Canonical SMILES
CC1CN(CC(O1)C)CC2=CC=C(C=C2)C=CC3=NNC4=C3C=CC(=C4)C5CC56C7=C(C=CC(=C7)OC)NC6=O
2.1.5 Isomeric SMILES
C[C@@H]1CN(C[C@@H](O1)C)CC2=CC=C(C=C2)/C=C/C3=NNC4=C3C=CC(=C4)[C@@H]5C[C@]56C7=C(C=CC(=C7)OC)NC6=O
2.2 Other Identifiers
2.2.1 UNII
TL1UD860AA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(3-(4-((2,6-dimethylmorpholino)methyl)styryl)-1h-indazol-6-yl)-5'-methoxyspiro(cyclopropane-1,3'-indolin)-2'-one

2. Cfi-400945

2.3.2 Depositor-Supplied Synonyms

1. Cfi-400945

2. 1338806-73-7

3. Cfi-400945 (free Base)

4. Tl1ud860aa

5. 1338806-76-0

6. 1616420-30-4

7. (2's,3r)-2'-[3-[(e)-2-[4-[[(2r,6s)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]ethenyl]-1h-indazol-6-yl]-5-methoxyspiro[1h-indole-3,1'-cyclopropane]-2-one

8. Cfi400945

9. (2's,3r)-2'-[3-[(e)-2-[4-[[(2s,6r)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]ethenyl]-1h-indazol-6-yl]-5-methoxyspiro[1h-indole-3,1'-cyclopropane]-2-one

10. Spiro(cyclopropane-1,3'-(3h)indol)-2'(1'h)-one, 2-(3-((1e)-2-(4-(((2r,6s)-2,6-dimethyl-4-morpholinyl)methyl)phenyl)ethenyl)-1h-indazol-6-yl)-5'-methoxy-, (1r,2s)-

11. Ocifisertib

12. Unii-tl1ud860aa

13. Schembl9946383

14. Gtpl12083

15. Ex-a1609

16. Nsc791966

17. S7552

18. Zinc145048061

19. Ccg-269938

20. Cs-5939

21. Nsc-791966

22. Sb17032

23. Cfi-400945,

24. Ac-36327

25. As-35185

26. Hy-12300

27. A935188

28. (1r,2s)-2-(3-((e)-4-(((2r,6s)-2,6-dimethyl Morpholino)methyl)styryl)-1h-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

29. (1r,2s)-2-(3-((e)-4-(((2r,6s)-2,6-dimethylmorpholino)methyl)styryl)-1h-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one

2.4 Create Date
2012-08-19
3 Chemical and Physical Properties
Molecular Weight 534.6 g/mol
Molecular Formula C33H34N4O3
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass534.26309096 g/mol
Monoisotopic Mass534.26309096 g/mol
Topological Polar Surface Area79.5 Ų
Heavy Atom Count40
Formal Charge0
Complexity942
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 1338806-73-7 / CFI-400945 API manufacturers, exporters & distributors?

CFI-400945 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of CFI-400945 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CFI-400945 manufacturer or CFI-400945 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CFI-400945 manufacturer or CFI-400945 supplier.

PharmaCompass also assists you with knowing the CFI-400945 API Price utilized in the formulation of products. CFI-400945 API Price is not always fixed or binding as the CFI-400945 Price is obtained through a variety of data sources. The CFI-400945 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CFI-400945

Synonyms

1338806-73-7, Cfi-400945 (free base), Tl1ud860aa, 1338806-76-0, 1616420-30-4, (2's,3r)-2'-[3-[(e)-2-[4-[[(2r,6s)-2,6-dimethylmorpholin-4-yl]methyl]phenyl]ethenyl]-1h-indazol-6-yl]-5-methoxyspiro[1h-indole-3,1'-cyclopropane]-2-one

Cas Number

1338806-73-7

Unique Ingredient Identifier (UNII)

TL1UD860AA

About CFI-400945

PLK4 Inhibitor CFI-400945 is a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle.

CFI-400945 Manufacturers

A CFI-400945 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CFI-400945, including repackagers and relabelers. The FDA regulates CFI-400945 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CFI-400945 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CFI-400945 Suppliers

A CFI-400945 supplier is an individual or a company that provides CFI-400945 active pharmaceutical ingredient (API) or CFI-400945 finished formulations upon request. The CFI-400945 suppliers may include CFI-400945 API manufacturers, exporters, distributors and traders.

CFI-400945 GMP

CFI-400945 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CFI-400945 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CFI-400945 GMP manufacturer or CFI-400945 GMP API supplier for your needs.

CFI-400945 CoA

A CFI-400945 CoA (Certificate of Analysis) is a formal document that attests to CFI-400945's compliance with CFI-400945 specifications and serves as a tool for batch-level quality control.

CFI-400945 CoA mostly includes findings from lab analyses of a specific batch. For each CFI-400945 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CFI-400945 may be tested according to a variety of international standards, such as European Pharmacopoeia (CFI-400945 EP), CFI-400945 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CFI-400945 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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